[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100566638":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":24,"centralContacts":29,"locations":34,"responsibleParty":57,"collaborators":10,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":10,"enrollmentInfo":69,"targetDuration":10,"studyType":72,"phases":10,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Centre Hospitalier Universitaire de la Guadeloupe","OTHER",[8,12,15,18,21],{"label":9,"type":10,"description":11,"interventionNames":10},"leptospirosis",null,"patient suffering from leptospirosis",{"label":13,"type":10,"description":14,"interventionNames":10},"bacterial","patient suffering from bacterial infections including in-hospital-acquired-infections",{"label":16,"type":10,"description":17,"interventionNames":10},"viral","patient suffering from viral infection except COVID-19",{"label":19,"type":10,"description":20,"interventionNames":10},"Control","patients non infected",{"label":22,"type":10,"description":23,"interventionNames":10},"viral infection SARS-COv2 +","patient suffering from COVID-19 previously enrolled in PLAQCOVID trial.",[25],{"name":26,"affiliation":27,"role":28},"Frédéric MARTINO, Doctor","chu de pointe à pitre","PRINCIPAL_INVESTIGATOR",[30],{"name":26,"role":31,"phone":32,"phoneExt":10,"email":33},"CONTACT","+590 590 89 10 10","frederic.martino@chu-guadeloupe.fr",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":39,"countryCode":10,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Centre Hospitalier Universitaire de la Guadeloup","RECRUITING","Les Abymes","Guadeloupe","97139",{"type":42,"coordinates":43},"Point",[44,45],-61.50507,16.273,{"lat":45,"lon":44},[48,52,56],{"name":49,"role":31,"phone":50,"phoneExt":10,"email":51},"Valérie SOTER","+590 590 934677","valerie.soter@chu-guadeloupe.fr",{"name":53,"role":31,"phone":54,"phoneExt":10,"email":55},"Eunice NUBRET","+590 590 934686","eunice.nubret@chu-guadeloupe.fr",{"name":26,"role":31,"phone":10,"phoneExt":10,"email":10},{"type":58,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100566638","study-and-role-of-inflammasome-in-platelet-activation-during-bacterial-andor-viral-sepsis-100566638",false,"NCT06657781","Study and Role of Inflammasome in Platelet Activation During Bacterial And\u002For Viral Sepsis","PLAQSEPSIS","Inclusion Criteria:\n\n* For all groups: patients older than 18 years at inclusion and acceptation of participation by the patient, his relative or his legal representative (depending on the situation)\n* For groups 1, 2, 3 and 5: Patient with a confirmed sepsis (microbiological confirmation)\n* For group 4 : Patient non infected\n\nExclusion Criteria:\n\n* Refusal of participation by the patient, his relative or his legal representative (depending on the situation)\n* Patients subject to a safeguard measure of justice\n* Patients younger than 18 years at inclusion",true,"ALL","18 Years",{"count":70,"type":71},171,"ESTIMATED","OBSERVATIONAL",": Sepsis, now defined as life-threatening organ dysfunction due to a dysregulated host response to infection, is an important global health problem representing about a fifth of all global deaths. It can be associated, in some cases, with multiple organ failure and cytokine storm. The main objective of this study is to estimate and to compare the activation rate of the Nucleotide-binding domain Leucine Rich repeat containing Protein 3 (NLRP3) inflammasome in platelets between five groups of patients suffering from bacterial and\u002For viral sepsis, with different severity levels according to Sequential Organ Failure Assessment (SOFA) score to precise the platelets' implication in this cytokine storm.",[75],"Bacterial Sepsis",[77,78,79,80,81],"Sepsis","platelet","NLRP3","BTK","IL-1β","2024-10-23",{"date":84,"type":85},"2024-10-24","ACTUAL",{"date":87,"type":85},"2022-11-30",{"date":89,"type":71},"2026-11",{"name":5,"class":6},1]