[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100536826":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":51,"collaborators":25,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":25,"enrollmentInfo":64,"targetDuration":25,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":77,"whyStopped":25,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Johannes Gutenberg University Mainz","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intravenous Adenosine","ACTIVE_COMPARATOR","Invasive microvascular function assessment will be conducted by administering intravenous hyperemic agent adenosine.",[13],"Diagnostic Test: microvascular function assessment",{"label":15,"type":16,"description":17,"interventionNames":18},"Intracoronary Adenosine","EXPERIMENTAL","Invasive microvascular function assessment will be conducted by administering intracoronary hyperemic agent adenosine.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIAGNOSTIC_TEST","microvascular function assessment","mircovascular function parameters will be measured by administering adenosine in two different pathways",[15,9],null,[27],{"name":28,"affiliation":29,"role":30},"Tommaso Gori, MD,PhD","Center of Cardiology, Cardiology I, University Medical Center Mainz","PRINCIPAL_INVESTIGATOR",[32],{"name":33,"role":34,"phone":35,"phoneExt":25,"email":36},"Tommaso Gori, MD, PhD","CONTACT","00496131172829","tomgori@hotmail.com",[38],{"facility":39,"status":25,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":25},"Center of Cardiology, Cardiology I, university hospital Mainz","Mainz","Rhineland-Palatinate","55131","Germany","DE",{"type":46,"coordinates":47},"Point",[48,49],8.28008,49.98185,{"lat":49,"lon":48},{"type":30,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Tommaso Gori","Professor","100536826","study-comparing-two-administration-pathways-for-adenosine-during-microvascular-function-assessment-100536826",false,"NCT06269874","Study Comparing Two Administration Pathways for Adenosine During Microvascular Function Assessment","A Single-centric, ProspectivE, Randomized Controlled Study Comparing Two Administration Pathways for Adenosine During Invasive Assessment of Microvascular Function in Patients With ANOCA.","ASPERA-ANOCA","Inclusion Criteria:\n\n* Chronic coronary syndrome (including patients with anginal equivalents).\n* Indication to cardiac catheterization;\n* Indication to the assessment of microvascular function (note: patients will be asked for participation and consented prior to the first measurement of microvascular function, which will be conducted as per clinical indication)\n* Willingness to participate and ability to understand, read and sign the informed consent\n* Age\\>18 years\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Bronchial asthma, COPD (chronic obstructive pulmonary disease)\n* Secondary or tertiary atrioventricular block without prior pacemaker implantation\n* Previous CABG (coronary artery bypass graft) with patent grafts to the left anterior descending coronary\n* Epicardial coronary disease (FFR \\\u003C0.80 with evidence of a focal stenosis) in the left anterior descending territory\n* Inability to provide informed consent","ALL","18 Years",{"count":65,"type":66},40,"ESTIMATED","INTERVENTIONAL",[69],"NA","The aim of this study is to investigate the agreement and reproducibility between intravenous and intracoronary adenosine administration during invasive assessment of microvascular function.\n\nGoals of this study are:\n\n1. Agreement and reproducibility between intravenous and intracoronary adenosine administration in the IMR (Index of microvascular resistance) value.\n2. Agreement and reproducibility of FFR(fractional flow reserve), CFR (coronary flow reserve), MRR (microvascular resistance reserve), RRR (resistive reserve ratio) and reproducibility of each of these as compared with CFRabs (absolute coronary flow).\n3. Time required for IMR measurements",[72],"Microvascular Coronary Artery Disease",[74,75,76],"adenosine","coronary microvascular assessment","microvascular disease","NOT_YET_RECRUITING","2024-10-06",{"date":80,"type":81},"2024-10-08","ACTUAL",{"date":83,"type":66},"2027-03-02",{"date":85,"type":66},"2027-08-31",{"name":5,"class":6},1]