[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100489352":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":49,"responsibleParty":81,"collaborators":84,"id":90,"slug":91,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":52,"eligibilityCriteria":96,"healthyVolunteers":92,"sex":97,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":52,"studyType":103,"phases":104,"briefSummary":106,"conditions":107,"keywords":111,"overallStatus":114,"whyStopped":52,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"Centre Hospitalier Universitaire Vaudois","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Matrix-Assisted Autologous Chondrocytes Transplantation (MACT)","EXPERIMENTAL","Matrix-Assisted Autologous Chondrocytes Transplantation (MACT, also called third generation of autologous chondrocyte implantation) is based on the use of type I\u002FIII collagen membrane as a three-dimensional structural support on which autologous articular chondrocytes are seeded and cultured to form cartilage prior to implantation.",[13],"Procedure: MACT",{"label":15,"type":16,"description":17,"interventionNames":18},"The Augmented Microfracture Technique (AMT)","ACTIVE_COMPARATOR","The Augmented Microfracture Technique (AMT, also called Autologous Matrix-Induced Chondrogenesis or AMIC) which is part of a therapeutic continuum, combines a microfracture treatment with the application of a type I\u002FIII collagen membrane. The principle is to cover the microfractured area with a resorbable membrane to stabilize the formed blood clot in order to increase the concentration of mesenchymal stem cells and promote their differentiation into a repaired tissue.",[19],"Procedure: AMT",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","MACT","* A biopsy of healthy cartilage is taken from a non-weight bearing area of the knee joint during an arthroscopic procedure.\n* The biopsy is processed in the GMP accredited laboratory to isolate and amplify chondrocytes.\n* The cells are seeded and cultured on a collagen matrix (Chondro-Gide®, Geistlich Pharma)\n* The membrane is implanted and sutured onto the injured site.",[9],[27],"Third generation of ACI",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"AMT","This treatment combines the microfracture procedure with the application of a bilayer matrix of porcine type I\u002FIII collagen (Chondro-Gide, Geistlich Pharma) and the supplementation of autologous bone.",[15],[33],"AMIC",[35],{"name":36,"affiliation":37,"role":38},"Robin MARTIN, MD","CHUV","PRINCIPAL_INVESTIGATOR",[40,45],{"name":36,"role":41,"phone":42,"phoneExt":43,"email":44},"CONTACT","021 314 76 79","41","robin.martin@chuv.ch",{"name":46,"role":41,"phone":47,"phoneExt":43,"email":48},"Virginie PHILIPPE, Ph-D","021 314 90 18","virginie.philippe@chuv.ch",[50,69],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Hôpital Fribourgeois- HFR",null,"Fribourg","Canton of Fribourg","1708","Switzerland","CH",{"type":59,"coordinates":60},"Point",[61,62],7.15128,46.80237,{"lat":62,"lon":61},[65],{"name":66,"role":41,"phone":67,"phoneExt":43,"email":68},"Daniel PETEK, MD","78 709 86 04","daniel.petek@h-fr.ch",{"facility":70,"status":52,"city":71,"state":72,"zip":73,"country":56,"countryCode":57,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"Centre Hospitalier Universitaire Vaudois - CHUV","Lausanne","Canton of Vaud","1011",{"type":59,"coordinates":75},[76,77],6.63282,46.516,{"lat":77,"lon":76},[80],{"name":36,"role":41,"phone":42,"phoneExt":43,"email":44},{"type":38,"investigatorFullName":82,"investigatorTitle":83,"investigatorAffiliation":5,"oldNameTitle":52,"oldOrganization":52},"Dr. Robin Martin","Principal Investigator",[85,88],{"name":86,"class":87},"Virginie PHILIPPE","UNKNOWN",{"name":89,"class":87},"Lee Ann LAURENT APPLEGATE","100489352","study-comparing-two-methods-for-the-treatment-of-large-chondral-and-osteochondral-defects-of-the-knee-100489352",false,"NCT05651997","Study Comparing Two Methods for the Treatment of Large Chondral and Osteochondral Defects of the Knee","Randomized Study Comparing Two Methods for the Treatment of Large Chondral and Osteochondral Defects of the Knee: Augmented Microfracture Technique vs. 3rd Generation of ACI","Inclusion Criteria:\n\n* Patients aged between 15-50 years\n* Symptomatic chondral and osteochondral defect, grade III and IV according to the ICRS classification, and size between 2.5 and 15 cm2\n* Failure of a conservative treatment\n* Patient in good general condition, documented by an ASA score ≤ 2 (American Society of Anesthesiologists)\n* Patient considered compliant and able to participate in rehabilitation and pre- and post-operative follow-up\n* Consent to participate in the study\n\nExclusion Criteria:\n\n* All inflammatory and synovial pathologies\n* Diffuse or mirror lesions\n* An unfavorable biomechanical environment\n* Obesity grade II or higher, with a BMI\\>35 kg\u002Fm2\n* Active smoking\u002F active drug dependency (hard drugs)\n* Poor compliance\n* The patient is already part of another clinical trial that may compromise the present study\n* Vulnerable populations (except minors aged 15-18 years)\n* Presence of open growth plate (15-18 years)\n* Pregnancy or planned pregnancy during the study (MRI-related contra-indication)\n* Proven allergy to penicillin and gentamicin (for MACT group) and porcine collagen (for both groups)\n\nFor final inclusion, an additional exclusion criteria will be assessed after randomization:\n\n\\- Positive to HIV, HBV, HCV, syphilis.","ALL","15 Years","50 Years",{"count":101,"type":102},80,"ESTIMATED","INTERVENTIONAL",[105],"NA","The major objective of this study is to evaluate the efficacy of the MACT versus the AMT for the treatment of large cartilage defects in patellofemoral and femorotibial injuries.",[108,109,110],"Articular Cartilage Defect","Chondral Defect","Osteochondritis",[112,113],"Cellular therapy","Human articular chondrocytes","NOT_YET_RECRUITING","2026-03-10",{"date":117,"type":118},"2026-03-12","ACTUAL",{"date":120,"type":102},"2026-12",{"date":122,"type":102},"2032-06-01",{"name":5,"class":6},2]