[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632646":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":22,"centralContacts":22,"locations":22,"responsibleParty":23,"collaborators":22,"id":27,"slug":28,"hasResults":29,"nctId":30,"briefTitle":31,"officialTitle":32,"acronym":33,"eligibilityCriteria":34,"healthyVolunteers":35,"sex":36,"minAge":37,"maxAge":22,"enrollmentInfo":38,"targetDuration":22,"studyType":41,"phases":42,"briefSummary":44,"conditions":45,"keywords":47,"overallStatus":56,"whyStopped":22,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":22},{"fullName":5,"class":6},"Catholic University of the Sacred Heart","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"Cases","Participants with pancreatic ductal adenocarcinoma (PDAC) enrolled in the study. Participants provide clinical, epidemiological, and biospecimen data for assessment of polygenic risk score performance and evaluation of risk prediction models for PDAC.",[12],"Other: Blood sample collection",{"label":14,"type":6,"description":15,"interventionNames":16},"Controls","Participants without pancreatic ductal adenocarcinoma enrolled as controls. Participants provide clinical, epidemiological, and biospecimen data for comparison with PDAC cases and for assessment of polygenic risk score performance and PDAC risk prediction models.",[12],[18],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"Blood sample collection","Blood sample collection for biomarker and genetic analysis. Peripheral blood samples are collected from participants and used for laboratory analyses, including genotyping, biomarker assessment, and evaluation of polygenic risk score-based models for pancreatic ductal adenocarcinoma risk prediction.",[9,14],null,{"type":24,"investigatorFullName":25,"investigatorTitle":26,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"PRINCIPAL_INVESTIGATOR","Stefania Boccia","Full Professor","100632646","study-of-a-polygenic-risk-score-to-predict-the-risk-of-pancreatic-ductal-adenocarcinoma-100632646",false,"NCT07516392","Study of a Polygenic Risk Score to Predict the Risk of Pancreatic Ductal Adenocarcinoma","PRE-PDAC: Evaluation of Polygenic Risk scorE for Pancreatic Ductal AdenoCarcinoma Risk Prediction: a Case-control Study","PRE-PDAC","Inclusion Criteria:\n\n* Adults aged 18 years and older.\n* Able and willing to provide informed consent.\n* For cases: participants with pancreatic ductal adenocarcinoma.\n* For controls: participants without pancreatic ductal adenocarcinoma.\n* Availability of the clinical and\u002For biological data required for the study, including data necessary for polygenic risk score evaluation.\n\nExclusion Criteria:\n\n* Age younger than 18 years.\n* Inability to provide informed consent.\n* Incomplete or unavailable clinical and\u002For biological data required for the study.\n* Any condition that, in the judgment of the investigators, makes the participant unsuitable for inclusion",true,"ALL","18 Years",{"count":39,"type":40},1140,"ESTIMATED","INTERVENTIONAL",[43],"NA","This case-control study aims to evaluate the role of a polygenic risk score in predicting the risk of pancreatic ductal adenocarcinoma (PDAC). The study will compare genetic risk profiles between individuals with PDAC and controls without the disease in order to assess whether a polygenic risk score may help identify individuals at higher risk. The findings may contribute to improving risk stratification and supporting future strategies for early identification and prevention of pancreatic cancer.",[46],"Pancreatic Ductal Adenocarcinoma (mPDAC)",[48,49,50,51,52,53,54,55],"Pancreatic Cancer","polygenic risk score","PRS","pancreatic ductal adenocarcinoma","case-control study","risk prediction","genetic susceptibility","pancreatic neoplasms","NOT_YET_RECRUITING","2026-03-30",{"date":59,"type":60},"2026-04-08","ACTUAL",{"date":62,"type":40},"2026-04-01",{"date":64,"type":40},"2026-09-30",{"name":5,"class":6}]