[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100583728":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":20,"locations":26,"responsibleParty":46,"collaborators":11,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":11,"maxAge":11,"enrollmentInfo":56,"targetDuration":11,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":29,"whyStopped":11,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Centre Hospitalier Universitaire, Amiens","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"patients with syndromic, familial or complex orofacial clefts","EXPERIMENTAL",null,[13],"Genetic: blood withdrawal",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"GENETIC","blood withdrawal","blood withdrawal for genetic testing",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":11,"email":25},"Bénédicte DEMEER, MD","CONTACT","33+322087581","Demeer.Benedicte@chu-amiens.fr",[27],{"facility":28,"status":29,"city":30,"state":11,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"CHRU Amiens","RECRUITING","Amiens","80480","France","FR",{"type":35,"coordinates":36},"Point",[37,38],2.3,49.9,{"lat":38,"lon":37},[41,43],{"name":42,"role":23,"phone":24,"phoneExt":11,"email":25},"Benedicte Demeer, MD",{"name":44,"role":45,"phone":11,"phoneExt":11,"email":11},"Emilien Colin, MD","SUB_INVESTIGATOR",{"type":47,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100583728","study-of-congenital-orofacial-clefts-by-implementing-optical-genome-mapping-100583728",false,"NCT06880094","Study of Congenital Orofacial Clefts by Implementing Optical Genome Mapping","CARTOFENTE","Inclusion Criteria:\n\n* Individuals with syndromic, complex or familial oral-facial clefts\n* With no established genetic diagnosis\n* Followed up at the Amiens-Picardie University Hospital\n\nExclusion Criteria:\n\n* genetic diagnosis of oral-facial cleft\n* No health insurance affiliation\n* Patient under guardianship or curatorship, under safeguard of justice or deprived under public law\n* Pregnant, parturient or breast-feeding woman","ALL",{"count":57,"type":58},26,"ESTIMATED","INTERVENTIONAL",[61],"NA","Orofacial clefts, the most common congenital craniofacial malformations, have a complex etiology involving an interaction between genetic and environmental factors.\n\nChromosomal abnormalities, including structural variations, represent a major cause of human pathology. Recently, technological developments and the introduction of next-generation sequencing (NGS) technologies have revolutionized the field of medical genetics.\n\nOptical genome mapping (OGM) is an innovative, high-resolution \"long read\" technique that enables the identification of all classes of chromosomal variation, consisting in the direct visualization of long, labeled DNA molecules throughout the genome. This technology is gradually becoming an essential tool for studying onco-hematology and constitutional genetic pathologies The purpose of this study is to search for structural chromosomal variants (SV) or copy number variants (CNV) not identifiable either by cytogenetic methods nor by \"short read\" NGS \"short read, in individuals with oral-facial clefts with no genetic diagnosis.",[64,65,66],"Orofacial Clefts","Next Generation Sequencing (NGS)","Optical Genome Mapping",[68,69,66],"orofacial clefts","Next Generation Sequencing","2026-01-15",{"date":72,"type":73},"2026-01-16","ACTUAL",{"date":75,"type":73},"2025-02-18",{"date":77,"type":58},"2027-04",{"name":5,"class":6},1]