[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624650":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":28,"collaborators":11,"id":30,"slug":31,"hasResults":32,"nctId":33,"briefTitle":34,"officialTitle":35,"acronym":11,"eligibilityCriteria":36,"healthyVolunteers":37,"sex":38,"minAge":39,"maxAge":40,"enrollmentInfo":41,"targetDuration":11,"studyType":44,"phases":45,"briefSummary":34,"conditions":47,"keywords":11,"overallStatus":49,"whyStopped":11,"lastUpdateSubmitDate":50,"lastUpdatePostDateStruct":51,"startDateStruct":54,"completionDateStruct":56,"leadSponsor":58,"locationsCount":11},{"fullName":5,"class":6},"Hyundae Meditech","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"DIOSHA S Lido Injection","EXPERIMENTAL",null,[13],"Device: DIOSHA S Lido",{"label":15,"type":16,"description":11,"interventionNames":17},"YOUTHFILL Fine with Lidocaine Injection","ACTIVE_COMPARATOR",[18],"Device: YOUTHFILL Fine with Lidocaine",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DEVICE","DIOSHA S Lido","Injection of a hyaluronic acid dermal filler containing lidocaine into the nasolabial folds for the temporary correction of moderate to severe nasolabial folds. Treatment is administered according to the study protocol, and participants are followed through Week 48 for efficacy and safety assessments.",[9],{"type":21,"name":26,"description":23,"armGroupLabels":27,"otherNames":11},"YOUTHFILL Fine with Lidocaine",[15],{"type":29,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100624650","study-of-diosha-s-lido-injection-vs-youthfill-fine-with-lidocaine-in-treating-moderate-to-severe-nasolabial-folds-100624650",false,"NCT07412392","Study of DIOSHA S Lido Injection vs. YOUTHFILL Fine With Lidocaine in Treating Moderate to Severe Nasolabial Folds","A Multi Center, Randomized, Subject & Independent Evaluator-blinded, Matched Pairs, Active Controlled, Non-inferiority, Pivotal Study to Evaluate the Efficacy and Safety of Injection With DIOSHA S Lido as Compared to YOUTHFILL(YOUTHFILL Fine With Lidocaine) in Temporary Correction of Moderate to Severe Nasolabial Folds","Inclusion Criteria:\n\n* Adults aged 19 to 75 years\n* Voluntarily provided written informed consent\n* Moderate to severe symmetrical nasolabial folds (WSRS score 3 or 4 on both sides)\n* Agree to discontinue other facial dermatologic treatments (e.g., fillers, botulinum toxin, laser) during the study\n* Able to understand instructions and comply with study procedures\n\nExclusion Criteria:\n\n* Active facial skin disease, infection, or untreated scars in the treatment area\n* History of severe allergy or hypersensitivity to device components\n* Facial aesthetic or invasive procedures in the treatment area within 6 months prior to screening\n* Use of prohibited medications within required washout periods\n* Participation in another interventional clinical trial within 4 weeks prior to screening or during the study\n* Pregnancy, breastfeeding, or non-compliance with contraception requirements\n* Any condition deemed inappropriate by the investigator",true,"ALL","19 Years","75 Years",{"count":42,"type":43},60,"ESTIMATED","INTERVENTIONAL",[46],"NA",[48],"Nasolabial Folds, Wrinkles","NOT_YET_RECRUITING","2026-02-09",{"date":52,"type":53},"2026-02-17","ACTUAL",{"date":55,"type":43},"2026-02-27",{"date":57,"type":43},"2027-07-30",{"name":5,"class":6}]