[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100517363":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":44,"centralContacts":49,"locations":58,"responsibleParty":117,"collaborators":119,"id":123,"slug":124,"hasResults":125,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":24,"eligibilityCriteria":129,"healthyVolunteers":130,"sex":131,"minAge":132,"maxAge":133,"enrollmentInfo":134,"targetDuration":24,"studyType":137,"phases":138,"briefSummary":140,"conditions":141,"keywords":143,"overallStatus":61,"whyStopped":24,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":157},{"fullName":5,"class":6},"The Institute of Molecular and Translational Medicine, Czech Republic","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"LDCT and collection of breath condensate and blood sample","EXPERIMENTAL","Each participant of the study will provide exhaled breath condensate sample and blood sample for further laboratory analyses. Each participant will have LDCT (low dose computer tomography) performed. A pulmonologist examines the patient for any concomitant diseases and performs spirometry. Vital signs will be measured.",[13,14,15,16,17],"Diagnostic Test: Exhaled breath condensate sampling","Diagnostic Test: Blood sampling","Procedure: LDCT","Diagnostic Test: Vital signs","Diagnostic Test: Spirometry",[19,25,29,36,40],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIAGNOSTIC_TEST","Exhaled breath condensate sampling","Patient will breath for approx. 10 minutes to a breath condenser. The exhaled breath sample will be condensed and freezed.",[9],null,{"type":20,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Blood sampling","A venous blood sample will be taken for further biomarker analysis.",[9],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"PROCEDURE","LDCT","LDCT scan will be performed.",[9],[35],"Low Dose Computer Tomography",{"type":20,"name":37,"description":38,"armGroupLabels":39,"otherNames":24},"Vital signs","Blood pressure, weight, height, pulse, oxygen saturation will be measured.",[9],{"type":20,"name":41,"description":42,"armGroupLabels":43,"otherNames":24},"Spirometry","Spirometry will be performed.",[9],[45],{"name":46,"affiliation":47,"role":48},"Marian Hajduch, MD, PhD.","IMTM, Palacky University in Olomouc, Faculty of Medicine and Dentistry","STUDY_DIRECTOR",[50,54],{"name":46,"role":51,"phone":52,"phoneExt":24,"email":53},"CONTACT","+420 585632083","marian.hajduch@upol.cz",{"name":55,"role":51,"phone":56,"phoneExt":24,"email":57},"Michaela Bendova, MSc.","+420585632050","michaela.bendova@upol.cz",[59,80,99],{"facility":60,"status":61,"city":62,"state":24,"zip":63,"country":64,"countryCode":24,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"Masaryk Memorial Cancer Institute","RECRUITING","Brno","65653","Czechia",{"type":66,"coordinates":67},"Point",[68,69],16.60796,49.19522,{"lat":69,"lon":68},[72,76],{"name":73,"role":51,"phone":74,"phoneExt":24,"email":75},"Pavel Turcani, MD, PhD.","+420543136409","pavel.turcani@mou.cz",{"name":77,"role":51,"phone":78,"phoneExt":24,"email":79},"Martina Lojova, MSc., PhD.","+420543136132","martina.lojova@mou.cz",{"facility":81,"status":82,"city":83,"state":24,"zip":84,"country":64,"countryCode":24,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"University Hospital","NOT_YET_RECRUITING","Olomouc","77900",{"type":66,"coordinates":86},[87,88],17.25175,49.59552,{"lat":88,"lon":87},[91,95],{"name":92,"role":51,"phone":93,"phoneExt":24,"email":94},"Petr Jakubec, MD, PhD.","+420588445918","petr.jakubec@fnol.cz",{"name":96,"role":51,"phone":97,"phoneExt":24,"email":98},"Miroslav Herman, prof.MD PhD.","+420588443495","miroslav.herman@fnol.cz",{"facility":100,"status":82,"city":101,"state":24,"zip":102,"country":64,"countryCode":24,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"General University Hospital in Prague","Prague","12808",{"type":66,"coordinates":104},[105,106],14.42076,50.08804,{"lat":106,"lon":105},[109,113],{"name":110,"role":51,"phone":111,"phoneExt":24,"email":112},"Jiri Votruba, MD, Ph.D.","+420 224 969 355","jiri.votruba@vfn.cz",{"name":114,"role":51,"phone":115,"phoneExt":24,"email":116},"Lenka Navratova, MD","+420224969352","lenka.navratova@vfn.cz",{"type":118,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[120],{"name":121,"class":122},"Cancer Research Foundation CR","UNKNOWN","100517363","study-of-early-cancer-biomarkers-in-breath-condensate-in-population-of-individuals-with-high-risk-of-lung-cancer-undergoing-ldct-screening-100517363",false,"NCT06016569","Study of Early Cancer Biomarkers in Breath Condensate in Population of Individuals With High-Risk of Lung Cancer Undergoing LDCT Screening.","Prospective Validation Study of Early Cancer Biomarkers in Breath Condensate of Individuals With High-Risk of Lung Cancer Undergoing Low-Dose Computer Tomography Based Screening.","Inclusion Criteria:\n\n1. Consent to participate in a clinical trial.\n2. A clients within an age of 55-74 years.\n3. Current smoker or ex-smoker who has smoked at least 20 pack-years, provided that:\n\n   1. priority will be given to clients who have smoked at least 30 pack-years.\n   2. preference will be given to a former smoker who has not smoked for less than 15 years.\n\nExclusion Criteria:\n\n1. Previous diagnosis of lung cancer.\n2. Progressing malignant tumor on symptomatic treatment.\n3. Advanced dementia\n4. Chronic obstructive pulmonary disease or other inflammatory disease in the phase of acute exacerbation.",true,"ALL","55 Years","74 Years",{"count":135,"type":136},3200,"ESTIMATED","INTERVENTIONAL",[139],"NA","The trial will evaluate if the newly identified biomarkers of lung cancer in exhaled breath condensate are as a diagnostic tool comparable to the low-dose computer tomography (LDCT) implemented in lung cancer screening recently. Due to the possibility to collect breath condensate at any medical workplace and due to the relatively low financial cost of examination of the collected breath condensate could improve early diagnosis of lung cancer, differential diagnostics of lung nodules and thereby reduce both the unnecessary interventions and deaths from this type of cancer.",[142],"Lung Cancer",[142,144,145,146,147],"Breath Condensate","Biomarker","Screening","Early Cancer Detection","2026-02-10",{"date":150,"type":151},"2026-02-12","ACTUAL",{"date":153,"type":151},"2023-06-01",{"date":155,"type":136},"2030-12",{"name":5,"class":6},3]