[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613355":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":39,"centralContacts":44,"locations":52,"responsibleParty":70,"collaborators":72,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":83,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":26,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":107,"overallStatus":117,"whyStopped":26,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":127},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8,16],{"label":9,"type":6,"description":10,"interventionNames":11},"RIF\u002FRPL group","Women undergoing ART with a history of recurrent implantation failure (RIF) and\u002For recurrent pregnancy loss (RPL).",[12,13,14,15],"Diagnostic Test: Endometrial Biopsy","Diagnostic Test: Vaginal Swab","Diagnostic Test: Blood sample","Diagnostic Test: Pelvic ultrasound (±pelvic MRI)",{"label":17,"type":6,"description":18,"interventionNames":19},"Control group","Women undergoing ART without a history of RIF or RPL.",[12,13,14,15],[21,27,31,35],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIAGNOSTIC_TEST","Endometrial Biopsy","Endometrial biopsy with Cornier Pipelle (part of the treatment in the RIF\u002FRPL group and some patients of the control group \u002F added for the research for the other patients of the control group)",[17,9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Vaginal Swab","Vaginal sample collection using a cotton swab. Part of the treatment",[17,9],{"type":22,"name":32,"description":33,"armGroupLabels":34,"otherNames":26},"Blood sample","Peripheral blood draw. Part of the treatment + 10 mL additional for research",[17,9],{"type":22,"name":36,"description":37,"armGroupLabels":38,"otherNames":26},"Pelvic ultrasound (±pelvic MRI)","Pelvic ultrasound (±pelvic MRI). Part of the treatment",[17,9],[40],{"name":41,"affiliation":42,"role":43},"Mathilde Bourdon, MD, PhD","Service de Gynécologie Obstétrique II et Médecine de la Reproduction - Cochin Hospital","PRINCIPAL_INVESTIGATOR",[45,49],{"name":41,"role":46,"phone":47,"phoneExt":26,"email":48},"CONTACT","00331 58 41 35 51","mathilde.bourdon@aphp.fr",{"name":50,"role":46,"phone":26,"phoneExt":26,"email":51},"Marie Benhammani-Godard","marie.godard@aphp.fr",[53],{"facility":42,"status":26,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Paris","IDF","75014","France","FR",{"type":60,"coordinates":61},"Point",[62,63],2.3488,48.85341,{"lat":63,"lon":62},[66,67],{"name":41,"role":46,"phone":47,"phoneExt":26,"email":51},{"name":68,"role":46,"phone":26,"phoneExt":26,"email":69},"Pietro Santulli, MD, PhD","pietro.santulli@aphp.fr",{"type":71,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[73,76,79],{"name":74,"class":75},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV",{"name":77,"class":78},"ADREGOF","UNKNOWN",{"name":80,"class":6},"URC-CIC Paris Descartes Necker Cochin","100613355","study-of-endometrial-immune-and-microbiological-modifications-in-cases-of-recurrent-implantation-failure-andor-recurrent-pregnancy-loss-100613355",false,"NCT07265505","Study of Endometrial Immune and Microbiological Modifications in Cases of Recurrent Implantation Failure and\u002For Recurrent Pregnancy Loss","Study of Immune and Microbiological Modifications of the Endometrium in Cases of Recurrent Implantation Failure and\u002For Recurrent Pregnancy Loss","IMERR","Inclusion Criteria:\n\n* Female aged ≥18 and \\\u003C36 years\n* Undergoing assisted reproductive technology (ART) in a fertility center\n* Covered by the French national health insurance system\n* Belonging to one of two groups:\n\n  * Study group: history of recurrent implantation failure (RIF) and\u002For recurrent pregnancy loss (RPL)\n  * Control group: no history of RIF or RPL\n\nExclusion Criteria:\n\n* Pregnant at inclusion\n* Refusal to provide written informed consent\n* Antibiotic use within one month prior to endometrial biopsy Positive serology for hepatitis B, hepatitis C or HIV\n* Uterine anatomical abnormalities (e.g., polyps, cavity-distorting fibroids, untreated hydrosalpinx)\n* Known chromosomal abnormality in either partner\n* Known autoimmune disease, thrombophilia, or antiphospholipid antibody syndrome\n* Persons under legal protection (e.g., guardianship, curatorship)","FEMALE","18 Years","35 Years",{"count":93,"type":94},100,"ESTIMATED","INTERVENTIONAL",[97],"NA","The IMERR study aims to improve understanding of certain causes of infertility related to recurrent implantation failure (RIF) and\u002For recurrent pregnancy loss (RPL), conditions that affect many women undergoing assisted reproductive technology (ART). Despite medical advances, some patients repeatedly fail to achieve pregnancy, or experience repeated miscarriages. These situations may be linked to subtle immune or microbial disturbances in the uterus. This study seeks to identify immune and microbiological profiles in the endometrium during the implantation window-a crucial period when the embryo attaches to the uterine wall. We will compare women who have experienced RIF and\u002For RPL with women who have had no such history. Blood and uterine samples will be analyzed to investigate whether certain immune or microbial features are associated with these reproductive failures. The ultimate goal is to uncover predictive factors that may explain why some women experience implantation failure or pregnancy loss, and to lay the foundation for future personalized treatments to improve reproductive outcomes.",[100,101,102,103,104,105,106],"Recurrent Implantation Failure","Recurrent Pregnancy Loss","Infertility, Female","Endometrial Diseases","Endometritis","Endometriosis","Adenomyosis",[108,109,110,111,112,113,114,115,116,106,105],"Uterine Immune Profile","Endometrial Receptivity","Infertility","Recurrent Miscarriage","IVF Failure","Implantation Window","Reproductive Immunology","Endometrial Microbiome","Chronic Endometritis","NOT_YET_RECRUITING","2026-02-03",{"date":120,"type":121},"2026-02-05","ACTUAL",{"date":123,"type":94},"2026-04",{"date":125,"type":94},"2031-04",{"name":5,"class":6},1]