[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633240":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":15,"locations":21,"responsibleParty":40,"collaborators":42,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":47,"sex":52,"minAge":53,"maxAge":7,"enrollmentInfo":54,"targetDuration":7,"studyType":57,"phases":7,"briefSummary":58,"conditions":59,"keywords":70,"overallStatus":24,"whyStopped":7,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"University Health Network, Toronto","OTHER",null,[9,13],{"name":10,"affiliation":11,"role":12},"Lillian Siu, MD","Princess Margaret Cancer Centre","PRINCIPAL_INVESTIGATOR",{"name":14,"affiliation":11,"role":12},"Scott Bratman, MD",[16],{"name":17,"role":18,"phone":19,"phoneExt":7,"email":20},"Kimberly Vuong","CONTACT","437-676-6598","Gilgan.Centre@uhn.ca",[22],{"facility":23,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"Princess Margaret Hospital","RECRUITING","Toronto","Ontario","M5G 2M9","Canada","CA",{"type":31,"coordinates":32},"Point",[33,34],-79.39864,43.70643,{"lat":34,"lon":33},[37,38,39],{"name":17,"role":18,"phone":19,"phoneExt":7,"email":7},{"name":10,"role":12,"phone":7,"phoneExt":7,"email":7},{"name":14,"role":12,"phone":7,"phoneExt":7,"email":7},{"type":41,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[43],{"name":44,"class":6},"Princess Margaret Hospital, Canada","100633240","study-of-high-precision-evaluation-of-molecular-residual-disease-through-a-platform-for-cancer-tracking-and-interception-sherlock-100633240",false,"NCT07524114","Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)","SHERLOCK","Inclusion Criteria:\n\n1. Patients with histopathological confirmation of cancer. Patients whose diagnosis are made by cytology may also be considered for this study. For tumor types that are typically diagnosed using unequivocal imaging findings or biomarker profiles (e.g. hepatocellular cancer, uveal melanoma), they can be eligible without histopathological or cytological confirmation.\n2. Patients must have cancer that is planned for or has undergone curative intent treatment (e.g. surgery, definitive radiation, definitive chemoradiation, adjuvant radiation, adjuvant chemotherapy, adjuvant chemoradiation, etc). Curative intent treatment must be completed within 12 months of study entry. For patients on adjuvant\u002Fmaintenance endocrine or biological therapy (e.g. bevacizumab, immunotherapy, etc), enrollment within 12 months of completion of curative intent treatment is allowed.\n3. Patient must be ≥ 18 years old.\n4. All patients must have signed and dated an informed consent form.\n\nExclusion Criteria:\n\n1. History of another active invasive cancer within 2 years prior to study enrolment. Exceptions include squamous and basal cell carcinoma of the skin and carcinoma in situ of the cervix, or malignancy that in the opinion of the investigator, is considered cured with minimal risk of recurrence within 2 years.\n2. Prior allogeneic stem cell transplant","ALL","18 Years",{"count":55,"type":56},7000,"ESTIMATED","OBSERVATIONAL","This study will collect, annotate, and sequence biospecimens (blood, tissue, urine, saliva and surgery drainage) from patients across different cancer types to detect molecular residual disease (MRD). Imaging scans and clinical data will also be gathered. This will allow for early cancer interception, and hopefully prolong relapse-free survival across tumor types. Results of ctDNA testing will be provided for clinical decisions and to determine eligibility for other linked interventional interception therapeutic studies, each of which will have a separate protocol.",[60,61,62,63,64,65,66,67,68,69],"Breast Cancer","Lung Cancer","Melanoma","Gynecologic Cancer","Genitourinary Cancer","Pancreatobiliary Cancer","Gastrointestinal Cancer","Head and Neck Cancer","Rare Cancer","Unknown Primary Tumors",[71,72,73],"Minimal Residual Disease","Liquid Biopsy","Circulating Tumor DNA","2026-05-06",{"date":76,"type":77},"2026-05-11","ACTUAL",{"date":79,"type":77},"2026-03-31",{"date":81,"type":56},"2031-03-31",{"name":5,"class":6},1]