[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633642":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":35,"locations":41,"responsibleParty":57,"collaborators":59,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":34,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":34,"enrollmentInfo":72,"targetDuration":34,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":87,"whyStopped":34,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Universidade do Porto","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"CAF + SCTG + Hyaluronic Acid","EXPERIMENTAL","Participants undergo coronally advanced flap (CAF) surgery combined with a subepithelial connective tissue graft (SCTG) with adjunctive application of cross-linked hyaluronic acid (hyaDENT BG®). The graft is immersed in hyaluronic acid prior to placement, and the gel is applied to the recipient site before flap closure.",[13,14],"Procedure: Coronally Advanced Flap with Connective Tissue Graft","Device: Cross-linked Hyaluronic Acid Gel",{"label":16,"type":17,"description":18,"interventionNames":19},"CAF + SCTG","ACTIVE_COMPARATOR","Participants undergo coronally advanced flap (CAF) surgery combined with a subepithelial connective tissue graft (SCTG) without adjunctive hyaluronic acid. The graft is handled under standard conditions and hydrated with sterile saline prior to placement.",[13],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Coronally Advanced Flap with Connective Tissue Graft","Standard periodontal plastic surgery procedure for root coverage involving coronally advanced flap (CAF) combined with a subepithelial connective tissue graft (SCTG). The technique aims to cover exposed root surfaces and improve soft tissue thickness and stability.",[16,9],[16],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DEVICE","Cross-linked Hyaluronic Acid Gel","Application of cross-linked hyaluronic acid gel (hyaDENT BG®) as an adjunct to periodontal surgery. The gel is applied to the recipient site and used to immerse the connective tissue graft prior to placement, aiming to enhance soft tissue healing, promote cell proliferation and angiogenesis, and improve clinical outcomes.",[9],[33],"hyaDENT BG®",null,[36],{"name":37,"role":38,"phone":39,"phoneExt":34,"email":40},"Marta M Abreu-Costa","CONTACT","+351911834256","martacostaa11@gmail.com",[42],{"facility":43,"status":34,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"CEPI - Clinical Center for Periodontology and Implantology","Porto","Porto District","4350-110","Portugal","PT",{"type":50,"coordinates":51},"Point",[52,53],-8.61097,41.1485,{"lat":53,"lon":52},[56],{"name":37,"role":38,"phone":39,"phoneExt":34,"email":40},{"type":58,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR",[60],{"name":61,"class":62},"Regedent AG, Zürich","UNKNOWN","100633642","study-of-hyaluronic-acid-used-with-gum-surgery-to-treat-gum-recession-in-adults-100633642",false,"NCT07529340","Study of Hyaluronic Acid Used With Gum Surgery to Treat Gum Recession in Adults","Effectiveness of Hyaluronic Acid Application in Coronally Advanced Flap Combined With a Subepithelial Connective Tissue Graft Versus Coronally Advanced Flap Combined With a Subepithelial Connective Tissue Graft Alone: A Clinical Trial","Inclusion Criteria:\n\n* \\- Age ≥ 18 years, in good general health (ASA I or II)\n* Presence of a single gingival recession defect classified as RT1 or RT2\n* Recession depth ≥ 2 mm with identifiable cemento-enamel junction (CEJ)\n* Presence of at least 1 mm of keratinized tissue at the defect site\n* No active periodontal disease (probing depth ≤ 4 mm and no bleeding on probing at the selected tooth)\n* Full-Mouth Plaque Score (FMPS ≤ 20%) and Full-Mouth Bleeding Score (FMBS ≤ 20%)\n* Vital tooth without caries, cervical lesions, or defective restorations\n* Good oral hygiene and motivation to maintain plaque control\n* Ability and willingness to comply with study procedures\n* Signed informed consent\n\nExclusion Criteria:\n\n* Uncontrolled systemic diseases (e.g., uncontrolled diabetes, severe cardiovascular disease, immunodeficiency)\n* Pregnant or breastfeeding women\n* Autoimmune diseases or immunosuppressive therapy\n* Known hypersensitivity to hyaluronic acid\n* Heavy smokers (\\>10 cigarettes\u002Fday) or recent tobacco use\n* Active periodontal disease at the study site\n* Caries, root fractures, endodontic lesions, or defective restorations at the study tooth\n* Previous mucogingival surgery at the study site\n* Recent use of antibiotics, corticosteroids, or anti-inflammatory drugs\n* Coagulation disorders or anticoagulant therapy contraindicating surgery\n* Hormonal disorders affecting wound healing\n* Acute oral infections\n* Any condition that may interfere with study participation or follow-up","ALL","18 Years",{"count":73,"type":74},34,"ESTIMATED","INTERVENTIONAL",[77],"NA","Gingival recession is a common condition in which the gum tissue recedes, exposing the root surface of the tooth. This can lead to tooth sensitivity, higher risk of root decay, and aesthetic concerns. A commonly used surgical treatment is the coronally advanced flap combined with a connective tissue graft (CAF + SCTG), which aims to cover the exposed root and improve gum health.\n\nHyaluronic acid (HA) is a naturally occurring substance in the body that plays an important role in wound healing. It may help improve tissue repair, reduce inflammation, and enhance healing after surgery.\n\nThis study aims to evaluate whether the use of hyaluronic acid (hyaDENT BG®) in addition to standard surgical treatment improves clinical outcomes in patients with gingival recession. Participants will be randomly assigned to receive either standard treatment alone or standard treatment with hyaluronic acid.\n\nThe main outcome is the proportion of sites with complete root coverage after 12 months. Additional outcomes include healing, gum tissue improvement, patient-reported pain and discomfort, and aesthetic results.\n\nThe study also includes a laboratory component to investigate how hyaluronic acid affects cells involved in gum healing.",[80],"Gingival Recession, Mucogingival Surgery",[82,83,84,85,86],"Gingival recession","Coronally advanced flap","Connective tissue graft","Hyaluronic acid","Mucogingival surgery","NOT_YET_RECRUITING","2026-04-14",{"date":90,"type":91},"2026-04-20","ACTUAL",{"date":93,"type":74},"2026-05",{"date":95,"type":74},"2027-09",{"name":5,"class":6},1]