[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622673":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":7,"locations":8,"responsibleParty":30,"collaborators":7,"id":32,"slug":33,"hasResults":34,"nctId":35,"briefTitle":36,"officialTitle":36,"acronym":37,"eligibilityCriteria":38,"healthyVolunteers":34,"sex":39,"minAge":40,"maxAge":7,"enrollmentInfo":41,"targetDuration":44,"studyType":45,"phases":7,"briefSummary":46,"conditions":47,"keywords":51,"overallStatus":54,"whyStopped":7,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":64},{"fullName":5,"class":6},"University College, London","OTHER",null,[9],{"facility":10,"status":7,"city":11,"state":7,"zip":12,"country":13,"countryCode":14,"cosmosGeoPoint":15,"geoPoint":20,"contacts":21},"Moorfields Eye Hospital","London","N17 9GZ","United Kingdom","UK",{"type":16,"coordinates":17},"Point",[18,19],-0.12574,51.50853,{"lat":19,"lon":18},[22,27],{"name":23,"role":24,"phone":25,"phoneExt":7,"email":26},"Achini K","CONTACT","07951650070","a.makuloluwa@nhs.net",{"name":28,"role":24,"phone":7,"phoneExt":7,"email":29},"James Bainbridge","j.bainbridge@ucl.ac.uk",{"type":31,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100622673","study-of-imaging-and-molecular-biomarkers-in-uncomplicated-rhegmatogenous-retinal-detachment-100622673",false,"NCT07386678","Study of Imaging and Molecular Biomarkers in Uncomplicated Rhegmatogenous Retinal Detachment","Cohort-NHS","Inclusion Criteria:\n\n* Adults ≥18 years\n* Uncomplicated primary rhegmatogenous retinal detachment\n* PVD present\n* No PVR-A\u002FB\u002FC\n* Phakic or pseudophakic.\n\nExclusion Criteria:\n\n* Patients \\\u003C18 years\n* Patients lacking capacity\n* Previous vitrectomy\n* Previous cryopexy\n* Aphakia\n* No fundal view\n* Diabetic retinopathy of any severity\n* Retinal detachment secondary to infective causes e.g. acute retinal necrosis, toxoplasmosis scars\n* Retinal detachment secondary to congenital defects e.g. optic disc pit\u002Fcoloboma\n* Exudative retinal detachment\n* Tractional retinal detachment\n* Ongoing involvement in another ocular trial.","ALL","18 Years",{"count":42,"type":43},50,"ESTIMATED","3 Months","OBSERVATIONAL","Disease or general study area: Uncomplicated rhegmatogenous retinal detachment (RRD) and risk of proliferative vittroretinopathy (PVR)\n\nPurpose and nature of the study:\n\n1. Characterise the cytokine profile of vitreous fluid in uncomplicated RRD.\n2. Develop a risk model to predict development of PVR after retinal detachment surgery using imaging and molecular biomarkers.\n3. To develop deep learning\u002Fartificial intelligence (AI) models for PVR detection in retinal detachment.\n\nInclusion criteria:\n\n50 adult ( ≥18 years) patients with uncomplicated rhegmatogenous retinal detachments without PVR.\n\nWhat participating will involve:\n\nPre- and post-operative assessments and intervention will follow standard of care for patients with rhegmatogenous retinal detachments.\n\nAdditional intervention will include non-invasive imaging of anterior chamber flare, vitreous, wide-field retina, macula optical coherence tomography (OCT) and macula OCT-angiography (OCT-A) as well as, seeking participant's consent on collecting their vitreous fluid at time of their surgery for cytokine analysis.",[48,49,50],"Retinal Detachment Rhegmatogenous","Proliferative Vitreoretinopathy","Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment",[52,53],"Cytokines","Imaging","NOT_YET_RECRUITING","2026-05-05",{"date":57,"type":58},"2026-05-06","ACTUAL",{"date":60,"type":43},"2026-04-27",{"date":62,"type":43},"2027-01-27",{"name":5,"class":6},1]