[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555983":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":29,"centralContacts":49,"locations":59,"responsibleParty":135,"collaborators":137,"id":145,"slug":146,"hasResults":147,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":151,"eligibilityCriteria":152,"healthyVolunteers":147,"sex":153,"minAge":10,"maxAge":154,"enrollmentInfo":155,"targetDuration":10,"studyType":158,"phases":10,"briefSummary":159,"conditions":160,"keywords":162,"overallStatus":62,"whyStopped":10,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":175},{"fullName":5,"class":6},"Istituto Ortopedico Rizzoli","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Children and adolescent with lower limb deformities",null,[12,13,14],"Other: Conservative treatment","Procedure: Single or multi-stage surgery","Procedure: Amputation",[16,20,25],{"type":6,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"Conservative treatment","Patients are provided with physiotherapy support and the provision of prostheses with the goal of ensuring as much walking functionality as possible.",[9],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"PROCEDURE","Single or multi-stage surgery","Correction of the deformity is pursued by one or more surgical procedures with the timing and the techniques (growth modulation, acute correction, gradual correction, soft tissues procedures, combined techniques) chosen according to the surgeon's preference to achieve the maximum possible walking functionality without orthopedic aids.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Amputation","Limb surgery, whether or not associated with realignment or soft-tissue surgery, is performed, aimed at providing the maximum possible walking function through a prosthesis.",[9],[30,34,37,40,43,46],{"name":31,"affiliation":32,"role":33},"Pierfrancesco Costici, MD","Ospedale Pediatrico Bambin Gesù","PRINCIPAL_INVESTIGATOR",{"name":35,"affiliation":36,"role":33},"Giorgio Marrè Brunenghi, MD","Istituto Giannina Gaslini",{"name":38,"affiliation":39,"role":33},"Fabio Verdoni, MD","Galeazzi Orthopedic Institute",{"name":41,"affiliation":42,"role":33},"Roberto Biagini, MD","Istituto Nazionale Tumori Regina Elena",{"name":44,"affiliation":45,"role":33},"Gianluigi Pasta, MD","Policlinico San Matteo",{"name":47,"affiliation":48,"role":33},"Tommaso Bonanzinga, MD","Istituto Clinico Humanitas",[50,56],{"name":51,"role":52,"phone":53,"phoneExt":54,"email":55},"Giovanni Trisolino, MD","CONTACT","0516366","484","giovanni.trisolino@ior.it",{"name":57,"role":52,"phone":10,"phoneExt":10,"email":58},"Alessandro Depaoli, MD","alessandro.depaoli@ior.it",[60,76,87,97,106,116,125],{"facility":61,"status":62,"city":63,"state":10,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"IRCCS Istituto Ortopedico Rizzoli","RECRUITING","Bologna","40136","Italy","IT",{"type":68,"coordinates":69},"Point",[70,71],11.33875,44.49381,{"lat":71,"lon":70},[74],{"name":51,"role":52,"phone":75,"phoneExt":54,"email":55},"05163666",{"facility":36,"status":77,"city":78,"state":10,"zip":10,"country":65,"countryCode":66,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"NOT_YET_RECRUITING","Genova",{"type":68,"coordinates":80},[81,82],11.87211,45.21604,{"lat":82,"lon":81},[85],{"name":35,"role":52,"phone":10,"phoneExt":10,"email":86},"giorgiomarre@gaslini.org",{"facility":39,"status":77,"city":88,"state":10,"zip":10,"country":65,"countryCode":66,"cosmosGeoPoint":89,"geoPoint":93,"contacts":94},"Milan",{"type":68,"coordinates":90},[91,92],12.59836,42.78235,{"lat":92,"lon":91},[95],{"name":38,"role":52,"phone":10,"phoneExt":10,"email":96},"fabio.verdoni@grupposandonato.it",{"facility":45,"status":77,"city":98,"state":10,"zip":10,"country":65,"countryCode":66,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"Pavia",{"type":68,"coordinates":100},[101,102],9.15917,45.19205,{"lat":102,"lon":101},[105],{"name":44,"role":52,"phone":10,"phoneExt":10,"email":10},{"facility":42,"status":77,"city":107,"state":10,"zip":10,"country":65,"countryCode":66,"cosmosGeoPoint":108,"geoPoint":112,"contacts":113},"Roma",{"type":68,"coordinates":109},[110,111],11.10642,44.99364,{"lat":111,"lon":110},[114],{"name":41,"role":52,"phone":10,"phoneExt":10,"email":115},"roberto.biagini@ifo.it",{"facility":117,"status":77,"city":107,"state":10,"zip":10,"country":65,"countryCode":66,"cosmosGeoPoint":118,"geoPoint":120,"contacts":121},"Ospedale Pediatrico Bambino Gesù",{"type":68,"coordinates":119},[110,111],{"lat":111,"lon":110},[122],{"name":123,"role":52,"phone":10,"phoneExt":10,"email":124},"Pier Francesco Costici, MD","pierfrancesco.costici@opbg.net",{"facility":48,"status":77,"city":126,"state":10,"zip":10,"country":65,"countryCode":66,"cosmosGeoPoint":127,"geoPoint":131,"contacts":132},"Rozzano",{"type":68,"coordinates":128},[129,130],9.1559,45.38193,{"lat":130,"lon":129},[133],{"name":47,"role":52,"phone":10,"phoneExt":10,"email":134},"tommaso.bonanzinga@hunimed.eu",{"type":136,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[138,140,141,142,143,144],{"name":117,"class":139},"UNKNOWN",{"name":36,"class":6},{"name":39,"class":139},{"name":42,"class":139},{"name":45,"class":139},{"name":48,"class":6},"100555983","study-of-infantile-lower-limb-malformations-and-deformities-100555983",false,"NCT06519175","Study of Infantile Lower Limb Malformations and Deformities","Observational Retrospective and Prospective Study of Infantile Lower Limb Malformations and Deformities","REMEDIA-I","Inclusion Criteria:\n\n* Age \\\u003C 18 years at the time of initial orthopedic evaluation\n* Diagnosis of congenital or acquired musculoskeletal deformity to one or both lower limbs\n* Presence of informed consent to participate in the study\n\nExclusion Criteria:\n\n* Refuse to participate in the study by the patient or parent\u002Flegal guardian\n* Patients with mild paramorphisms not associated with functional limitations","ALL","18 Years",{"count":156,"type":157},1000,"ESTIMATED","OBSERVATIONAL","The skeletal defects of the lower limbs in pediatric age encompass various congenital and acquired conditions that alter bone structure. These alterations can be symmetrical or asymmetrical, with potential consequences such as deformities, short stature, and disability. These condictions may impact not only on the physical and the mental function of the children, but also on their family context.\n\nManagement often requires a multidisciplinary approach for early diagnosis and treatment. Deformities are heterogeneous and necessitate a personalized therapeutic plan.\n\nCurrently, in pediatric orthopedic surgery there is a lack of an instrument capable of evaluating all these aspects.\n\nThe advancement of computer-assisted surgery and artificial intelligence could improve treatment customization and involve patients and families in therapeutic decision-making to prevent complications. This study aims to provide support for clinical practice to promote a systematic, comprehensive, and sequential evaluation of lower limb deformities in developmental age, from which epidemiological data and evidence on treatment approaches used in major referral centers can be extrapolated.",[161],"Deformity of Limb",[163,164,165],"Pediatric orthopedics","Deformity","Patient Reported Outcomes","2025-12-19",{"date":168,"type":169},"2025-12-26","ACTUAL",{"date":171,"type":169},"2024-10-31",{"date":173,"type":157},"2029-05",{"name":5,"class":6},7]