[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100462572":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":26,"responsibleParty":45,"collaborators":19,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":19,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":19,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":19,"overallStatus":29,"whyStopped":19,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Virginia Polytechnic Institute and State University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"LIFU, heat evoked fMRI signals","EXPERIMENTAL","fMRI resting and heat evoked signals performed after LIFU application to known brain region of interest or active sham region (within participant all conditions tested).",[13],"Other: Neuromodulation with low-intensity focused ultrasound",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Neuromodulation with low-intensity focused ultrasound","Application of LIFU to induce temporary neuromodulation, effects tested with resting state and heat evoked (QST) fMRI signals",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Jessica W Florig, MPH","CONTACT","540-526-2261","legonlab@vtc.vt.edu",[27],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Fralin Biomedical Research Institute","RECRUITING","Roanoke","Virginia","24016","United States","US",{"type":36,"coordinates":37},"Point",[38,39],-79.94143,37.27097,{"lat":39,"lon":38},[42],{"name":43,"role":23,"phone":44,"phoneExt":19,"email":25},"Jessica Florig, MPH","5405262375",{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"PRINCIPAL_INVESTIGATOR","Wynn Legon","Assistant Professor","100462572","study-of-low-intensity-focused-ultrasound-effects-on-heat-evoked-fmri-signals-100462572",false,"NCT05303415","Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals","Inclusion Criteria:\n\n* Healthy volunteers, all ethnicities, who understand and speak English.\n\nExclusion Criteria:\n\nClaustrophobia (scanning environment may be uncomfortable). Contraindications to MRI: including pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.\n\nContraindications to CT: pregnancy Active medical disorder or treatment with potential CNS effects (e.g. Alzheimer's) History of neurologic disorder. (e.g. Parkinson's, Epilepsy, or Essential Tremor) History of head injury resulting in loss of consciousness for \\>10 minutes. History of alcohol or drug dependence (through self-report).",true,"ALL","18 Years","65 Years",{"count":60,"type":61},80,"ESTIMATED","INTERVENTIONAL",[64],"NA","Study of LIFU on fMRI pain signals. Participants receive low-intensity focused ultrasound (LIFU) and fMRI scans to measure changes in both resting and heat pain signals. Physiology may also be measured. Questionnaires and symptom monitoring will take place. The study takes place over 4 study visits.",[67],"Pain","2026-06-04",{"date":70,"type":71},"2026-06-08","ACTUAL",{"date":73,"type":71},"2022-05-06",{"date":75,"type":61},"2027-12",{"name":5,"class":6},1]