[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100453709":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":35,"locations":10,"responsibleParty":44,"collaborators":46,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":10,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":75,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":10},{"fullName":5,"class":6},"University Hospital, Grenoble","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Normal, pathological IVG",null,"We will use placenta and fetal memebranes collected from first trimester termination of pregnancy. This will constitute group IVG.",[13],"Diagnostic Test: Histology",{"label":15,"type":10,"description":16,"interventionNames":17},"Normal and pathological term","We will also use the same specimens collected from third trimester pregnancies . We will call this group normal and pathological..... à finaliser",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIAGNOSTIC_TEST","Histology","Collect the placenta and fetal membranes and perfor either tissue culture or fixation for further analyses",[15,9],[25],"immunohistochemistry",[27,31],{"name":28,"affiliation":29,"role":30},"Pascale Hoffmann, MD PHD","Grenoble hospital","PRINCIPAL_INVESTIGATOR",{"name":32,"affiliation":33,"role":34},"Nadia Alfaidy, PhD","INSERM U1292","STUDY_DIRECTOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":10,"email":40},"Pascale Hoffmann, MD PhD","CONTACT","0476769223","PHoffmann@chu-grenoble.fr",{"name":32,"role":38,"phone":42,"phoneExt":10,"email":43},"0033632073234","nadia.alfaidy-benharouga@cea.fr",{"type":45,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[47],{"name":48,"class":49},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV","100453709","study-of-pregnancy-pathologies-associated-with-placental-abnormalities-100453709",false,"NCT05188066","Study of Pregnancy Pathologies Associated With Placental Abnormalities","Inclusion Criteria:\n\nAdult women\n\n* Admitted to the CHUGA for a birth or an abortion.\n* Pregnant women consenting to the collection of their fetal placenta membranes, during premature deliveries or at term of pregnancy OR Women performing an abortion consenting to the collection of their abortion products.\n* Having signed a consent\n* Affiliated with social security\n\nExclusion Criteria:\n\n* Placental sample or abortion product unavailable (not collected or necessary for treatment).\n* Patient with known positive HIV or Hepatitis B or Hepatitis C serology or at risk according to the infectious safety criteria applied by the EFS.\n* hemoglobin \\\u003C7d \u002F dL or hemoglobin \\\u003C10g \u002F dL if she suffers from a cardio-respiratory pathology).\n* Patient protected by law (minor, hospitalized under duress, subject to a legal protection measure by guardianship or curatorship, deprived of liberty by judicial or administrative decision)",true,"FEMALE","18 Years","52 Years",{"count":61,"type":62},800,"ESTIMATED","OBSERVATIONAL","Pregnancy pathologies can occur from implantation until childbirth. The investigators are interested in the development mechanisms of these pathologies and aim to develop therapies to treat them.\n\nThe investigators need to collect samples, especially placental samples, following abortions and term and premature deliveries. Abortions will allow investigators to have non-pathological placental material up to 13 weeks. This material will serve as a reference for the understanding of the histological changes that occur in normal placentas collected at term of pregnancy. The latter will, in turn, be compared with the placentas collected during premature deliveries. Also, the abortion product will be cultivated in an environment mimicking the pathology of pre-eclampsia. This study will allow investigators to advance their understanding of the pathophysiological mechanisms of the placenta. The investigators are internationally recognized for their research on these pathologies.",[66,67,68],"Pre-eclampsia","Pre-Term","Fetal Growth Retardation",[70,71,72,73,74],"pre-eclampsia","fetal growth retardation","placenta histology","vascularization","trophoblast proliferation","NOT_YET_RECRUITING","2022-01-07",{"date":78,"type":79},"2022-01-12","ACTUAL",{"date":81,"type":62},"2022-01-06",{"date":83,"type":62},"2030-01-31",{"name":5,"class":6}]