[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621989":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":10,"responsibleParty":30,"collaborators":10,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":10,"eligibilityCriteria":40,"healthyVolunteers":41,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":48,"studyType":49,"phases":10,"briefSummary":50,"conditions":51,"keywords":10,"overallStatus":53,"whyStopped":10,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":10},{"fullName":5,"class":6},"Sohag University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"HELLP syndrome group",null,"Pregnant patients diagnosed with HELLP syndrome enrolled prospectively to evaluate platelet indices and inflammatory markers and their prognostic value on maternal and clinical outcomes.",[13],"Diagnostic Test: Group I: 30 patients with HELLP syndrome",{"label":15,"type":10,"description":16,"interventionNames":17},"Healthy pregnant controlled group","Healthy pregnant women without hypertensive disorders of pregnancy recruited as a control group for comparison.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","Group I: 30 patients with HELLP syndrome","All patients will be subjected to the following in ICU through 48 hrs\n\nDetailed medical history taking:\n\nDemographic data (age, weight, height, body mass index (BMI). Physical examination (conscious level-vital signs) Type of anesthesia (spinal -general anesthesia) Number of pregnancies, parity, history of previous pregnancies, smoking status, and history of assisted reproductive treatments.\n\nLaboratory investigations, indices and inflammatory markers:\n\nwill be obtained after delivery, once the patient is admitted to the intensive care unit. Complete blood counts (CBC). Biochemical analyses \\[such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), albumin ,bilirubin and creatinine\\]. The indices include platelet count (PC), MPV, PDW, and plateletcrit (PCT), among these, PDW, an indicator of platelet size heterogeneity, is a marker of platelet function. It is being evaluated as a potential indicator for the risk prediction of",[9,15],[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Esraa Gaheen Ali, Resident","CONTACT","01066768174","esraa-jaheen-post@med.sohag.edu.eg",{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Esraa Jaheen Ali","Resident of Anesthesia,surgical Intensive Care, and Pain Management Faculty of Medicine, Sohag University","100621989","study-of-prognostic-values-of-platelet-indices-and-inflammatory-markers-in-patients-with-hellp-syndrome-100621989",false,"NCT07377786","Study of Prognostic Values of Platelet Indices and Inflammatory Markers in Patients With HELLP Syndrome.","Prognostic Values of Platelet Indices and Inflammatory Markers in Patients With HELLP Syndrome( Observational Controlled Study)","Inclusion Criteria:\n\n* Pregnant women aged 18 and 45 years. Gestational age ranged from 28 to 41 weeks. Pregnant women diagnosed with HELLP syndrome. Preeclampsia with Hellp syndrome. Pt with HELLP syndrome was delivered by ceserian section(SC)then admitted to Intensive care unit (ICU) only normal singleton pregnancies without fetal congenital or chromosomal anomalies\n\nExclusion Criteria:\n\n* Patients with infection and fever. Women with a history of diabetes, hypertension, systemic or endocrine disorder, chronic infection, chronic renal disease Liver diseases. Blood diseases. Drugs affecting platelet counts or functions. Any history of membrane rupture",true,"FEMALE","18 Years","45 Years",{"count":46,"type":47},60,"ESTIMATED","2 Days","OBSERVATIONAL","This study aims to evaluate the prognostic values of platelet indices and inflammatory markers in patients with HELLP syndrome as:- :-Primary outcome To investigate prognostic values of platelet indices and. . inflammatory markers in HELLP syndrome patients as main indices including (NLR-PLR-MPV-PDW and RDW). .\n\n-Secondary outcome. Evaluation complications of HELLP syndrome including. .\n\n* Maternal complication:- eclampsia, disseminated intravascular coagulation (DIC), liver rupture, placental abruption, stroke, and pulmonary or kidney failure. .\n* Fetal complication:-intra uterine fetal death(iufd) ,neonate need for admission to NICU , congintal anomalies .assess APGAR score (which assess appearance(skin color)-pulse(heart rate)-Grimace(reflex irritability)- Activity(muscle tone)-Respiratory(breathing efforts) or umblical cord PH\\\u003C7. .",[52],"HELLP Syndrome","NOT_YET_RECRUITING","2026-01-22",{"date":56,"type":57},"2026-01-30","ACTUAL",{"date":59,"type":47},"2026-02-01",{"date":61,"type":47},"2026-12",{"name":5,"class":6}]