[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645417":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":30,"responsibleParty":45,"collaborators":20,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":20,"maxAge":20,"enrollmentInfo":57,"targetDuration":20,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":33,"whyStopped":20,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Germans Trias i Pujol Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Interventional single arm","EXPERIMENTAL","During the donor's usual organ removal, a bicoronal incision and craniectomy will be performed to inject a small amount of indocyanin green into the meningeal space and evaluate migration with a fluorescence chamber. A small cervical lateral incision is added for flow monitoring and ends with the aesthetic closure of this. It will be completed with the aesthetic closure of the incisions, which can also be easily hidden.",[13],"Procedure: Indocynanine Green meningeal injection to understand anatomical connection from the meningeal lymphatic system to the cervical lymph nodes",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Indocynanine Green meningeal injection to understand anatomical connection from the meningeal lymphatic system to the cervical lymph nodes","Bicoronal incision and craniectomy will be performed to inject a small amount of indocyanin green into the meningeal space and evaluate migration with a fluorescence chamber. A small cervical lateral incision is added for flow monitoring and ends with the aesthetic closure of this. It will be completed with the aesthetic closure of the incisions, which can also be easily hidden.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Carmen Higueras, PhD","CONTACT","+34 934 65 12 00","chigueras.germanstrias@gencat.cat",{"name":28,"role":24,"phone":25,"phoneExt":20,"email":29},"Maria Del RIo, PhD","mariadelriomd@gmail.com",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":20},"Germans Trias i Pujol Universitary Hospital","RECRUITING","Badalona","Barcelona","08916","Spain","ES",{"type":40,"coordinates":41},"Point",[42,43],2.24741,41.45004,{"lat":43,"lon":42},{"type":46,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100645417","study-of-the-brains-natural-cleaning-system-in-potential-organ-donors-100645417",false,"NCT07682155","Study of the Brain's Natural Cleaning System in Potential Organ Donors.","Study of Drainage From the Cerebral Lymphatic System to Deep Cervical Nodes by the Migration of Indocyanine Green in Recent Cadaver","ICGBRAIN","Inclusion Criteria:\n\n* Potential organ donor patients, both in Brain Death and in Controlled Asystole, candidates to perform organ harvesting authorized by the Transplant and Tissue Coordination of the Universitary Germans Trias i Pujols Hospital, according to the usual channels and whose family members have previously signed the authorization of the donation and the specific informed consent of the study. Will be included in the study always after death is certified by neurological or cardiocirculatory criteria\n\nExclusion Criteria:\n\n* Absence of informed consent signed by family members.\n* Individuals with a history of having intracranial lymphatic drainage affected.",true,"ALL",{"count":58,"type":59},10,"ESTIMATED","INTERVENTIONAL",[62],"NA","Alzheimer's disease is a condition that affects the brain and is associated with the build-up of waste substances that can damage brain cells. Scientists have recently discovered a natural drainage and cleaning system around the brain, called the meningeal lymphatic system, which may help remove these waste products.\n\nResearchers believe that this brain drainage system is connected to lymph nodes located in the neck. However, this connection has not yet been clearly demonstrated in humans because it is difficult to study.\n\nThe purpose of this study is to investigate how fluid drains from the brain to the lymph nodes in the neck. To do this, researchers will use a fluorescent dye called indocyanine green, which can be seen with a special camera. The study will be carried out in potential organ donors who have been authorized for organ donation.\n\nThe researchers will record images and videos to observe how the dye moves, how long it takes to reach the lymph nodes, whether the drainage is similar on both sides of the body, and which lymph nodes are involved.\n\nA better understanding of these drainage pathways may help researchers develop and improve future treatments for Alzheimer's disease and other neurological disorders.",[65],"Anatomical Description",[67,68,69],"Alzheimer's disease","meningeal lymphatic system","cervical lymph nodes","2026-06-26",{"date":72,"type":73},"2026-07-02","ACTUAL",{"date":75,"type":73},"2026-02-01",{"date":77,"type":59},"2026-12-31",{"name":5,"class":6},1]