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University","Zhuhai",{"type":48,"coordinates":683},[684,685],113.56778,22.27694,{"lat":685,"lon":684},[688],{"name":689,"role":37,"phone":690,"phoneExt":26,"email":691},"Xiaochun Shu","13326601313","zhshuxc@163.com",{"facility":693,"status":43,"city":694,"state":26,"zip":26,"country":45,"countryCode":46,"cosmosGeoPoint":695,"geoPoint":699,"contacts":700},"PKUCare Luzhong Hospital","Zibo",{"type":48,"coordinates":696},[697,698],118.06333,36.79056,{"lat":698,"lon":697},[701],{"name":702,"role":37,"phone":703,"phoneExt":26,"email":704},"Qun Liu","18553376569","596923216@qq.com",{"facility":706,"status":43,"city":694,"state":26,"zip":26,"country":45,"countryCode":46,"cosmosGeoPoint":707,"geoPoint":709,"contacts":710},"Zibo Central Hospital",{"type":48,"coordinates":708},[697,698],{"lat":698,"lon":697},[711],{"name":712,"role":37,"phone":713,"phoneExt":26,"email":714},"Xiaodong Zhao","18678186512","yy3731080c@163.com",{"type":716,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100505795","study-of-the-key-techniques-of-prevention-and-treatment-of-osteoporotic-refracture-100505795",false,"NCT05866029","Study of the Key Techniques of Prevention and Treatment of Osteoporotic Refracture","Efficacy of Sequential Denosumab After Teriparatide for 6 Months Compared With Denosumab Monotherapy in Reducing Risk of Osteoporotic Fractures in Patients With New Fractures: a Multicenter Randomized Controlled Trial (STAND Study)","Inclusion Criteria:\n\n1. New brittle hip fractures;\n2. New brittle vertebral fractures;\n3. New other site fractures and\u002For total hip or neck of femur or L1-L4 T-value \\< -1.0;\n4. Men or postmenopausal women;\n5. Age 45-90 years old;\n6. Ability to move autonomously\n\nExclusion Criteria:\n\n1. bone metabolic diseases except for osteoporosis eg. a. (Osteogenesis Imperfecta, Paget's disease, Osteomalacia), b. Cushing's syndrome, c.hyperprolactinemia;\n2. Having primary hyperparathyroidism or hypothyroidism;\n3. Had or have osteomyelitis of the jaw or necrosis of the jaw;\n4. GFR\\\u003C30ml\u002Fmin\u002F1.73m2;\n5. Active infection that requires systematic treatment;\n6. Used intravenous bisphosphonate, fluoride, or strontium for osteoporosis within 2 years;\n7. Used teriparatide and denosumab for osteoporosis within 6 months;\n8. Used glucocorticoids (equivalent to \\>5 mg\u002Fday prednisone) for more than 10 days within 6 weeks;\n9. The time gap between the first time and the last time oral bisphosphonate for osteoporosis less than 1 year( if used within one year, but the cumulative use is ≤ 1 month, the subject can be enrolled) ;\n10. Patients with malignant tumors or bone metastases within 5 years, except tumors that are expected to be cured after treatment;\n11. Have hypocalcemia and hypercalcemia;\n12. Unexplained elevation of alkaline phosphatase;\n13. A serious deficiency of vitamin D (25OHD \\<10ng\u002FmL);\n14. Patients who have previously received external radiation or radiation therapy with bone implants;\n15. Uncontrolled comorbidities included heart failure above the New York cardiac Function Scale, glycosylated hemoglobin \\> 8.5%, and severe arrhythmias;\n16. Planned pregnancy and lactation at present or during the study period;\n17. Allergic to teriparatide and denosumab;\n18. Participating in clinical trials of other drugs at present;\n19. subjects do not suitable for this study","ALL","45 Years","90 Years",{"count":728,"type":729},2478,"ESTIMATED","INTERVENTIONAL",[732],"NA","This project anchors osteoporotic fractures, conduct registration and follow-up studies, and conduct prospective treatment studies. By registering for follow-up studies on osteoporotic fractures, it is planned to obtain epidemiological data through registration and follow-up studies; A prospective treatment study for patients with osteoporotic fractures is planned to explore effective treatment strategies through randomized controlled trials; To study biomarkers for osteoporotic refractures, we plan to establish a biomarker warning model through multi omics research; To study imaging biomarkers for osteoporotic refractures, a new imaging technology is proposed to establish an imaging omics warning model.",[735],"Osteoporotic Fractures",[737,738,739,740],"osteoporosis","osteoporotic fractures","bone turnover markers","imaging biomarkers","2026-01-07",{"date":743,"type":744},"2026-01-12","ACTUAL",{"date":746,"type":744},"2023-05-26",{"date":748,"type":729},"2026-09-30",{"name":5,"class":6},58]