[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553667":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":19,"responsibleParty":35,"collaborators":7,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":43,"eligibilityCriteria":44,"healthyVolunteers":45,"sex":46,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":7,"studyType":52,"phases":7,"briefSummary":53,"conditions":54,"keywords":7,"overallStatus":21,"whyStopped":7,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":65},{"fullName":5,"class":6},"University of Bari Aldo Moro","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"MARIA FELICIA FAIENZA, MD","University of Bari","PRINCIPAL_INVESTIGATOR",[14],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},"Maria Felicia Faienza","CONTACT","+393687667438","mariafelicia.faienza@uniba.it",[20],{"facility":11,"status":21,"city":22,"state":7,"zip":23,"country":24,"countryCode":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"RECRUITING","Bari","70124","Italy","IT",{"type":27,"coordinates":28},"Point",[29,30],16.86982,41.12066,{"lat":30,"lon":29},[33],{"name":34,"role":16,"phone":7,"phoneExt":7,"email":7},"MARIA FELICIA MF FAIENZA",{"type":12,"investigatorFullName":15,"investigatorTitle":36,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Associate Professor of Pediatrics","100553667","study-of-the-thyroid-function-and-echostructural-morphology-in-patients-affected-with-rasopathies-ecoras2023-100553667",false,"NCT06489067","Study of the Thyroid Function and Echostructural Morphology in Patients Affected With Rasopathies (ECORAS2023)","Study of the Thyroid Function and Echostructural Morphology in Patients Affected With Rasopathies. An Italian Multicenter Study","ECORAS2023","Inclusion Criteria:\n\n* Genetically confirmed RASopathy\n* Age 3-25 years\n\nExclusion Criteria:\n\n* Previous radiotherapy treatments, known exposure to ionizing radiation\n* Iodine deficiency\n* Use of iodine-based compounds or drugs that interfere with thyroid function\n* Congenital hypothyroidism\u002Fhyperthyroidism\n* Severe obesity with metabolic complications",true,"ALL","3 Years","25 Years",{"count":50,"type":51},115,"ESTIMATED","OBSERVATIONAL","The study aims to evaluate the prevalence of thyroid disease, particularly with autoimmune pathogenesis (isolated hyperthyrotropinemia, hyperthyroidism, hypothyroidism, thyroid nodules) and\u002For morphostructural abnormalities of the thyroid gland in patients with RASopathy genetically confirmed by NGS technique (analysis of the genes: BRAF, CBL, HRAS, KRAS, LZTR1, MAP2K1, MAP2K2, MRAS, NRAS, PPP1CB, PTPN11, RAF1, RIT1, RRAS2, SHOC2, SOS1, SOS2) and to compare the data obtained in our sample with those of the general population.\n\nThe secondary aim of the study is to evaluate the association between vitamin D deficiency and\u002For other abnormalities of bone metabolism and thyroid disease and\u002For morphostructural anomalies of the thyroid gland in patients with RASopathy.",[55],"RASopathy","2024-07-03",{"date":58,"type":59},"2024-07-05","ACTUAL",{"date":61,"type":59},"2024-01-15",{"date":63,"type":51},"2024-06-30",{"name":5,"class":6},1]