[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100525663":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":33,"centralContacts":37,"locations":47,"responsibleParty":66,"collaborators":10,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":10,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":10,"studyType":83,"phases":10,"briefSummary":84,"conditions":85,"keywords":90,"overallStatus":50,"whyStopped":10,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Pirogov Russian National Research Medical University","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Symptomatic pelvic varicose veins (PVV)",null,"40 patients will include patients with symptomatic PVV (pelvic pain, dyspareunia, heaviness in the hypogastrium) and without symptoms and signs of CVD.",[13,14],"Diagnostic Test: Radionuclide venography","Diagnostic Test: single-photon emission computed tomography",{"label":16,"type":10,"description":17,"interventionNames":18},"Asymptomatic PVV","40 pdtients will consist of women with asymptomatic PVV with signs of CVD.",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"varicose veins of the lower limb","10 patients with varicose veins of the lower limb without PVV and pelvic congestion syndrome (PCS)",[13,14],[24,29],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"DIAGNOSTIC_TEST","Radionuclide venography","With the patient in an upright position, 370 MBq of 99mTc pertechnetate is injected into one of the dorsal veins of the foot after applying a tourniquet in the area of the ankle joint. Then, with the help of a gamma camera detector, the movement of the radiopharmaceutical is monitored in the following segments: tibial (muscular-venous pump of the lower leg), popliteal, femoral and iliocaval. To study the evacuation function of the muscular-venous pump (MVP) of the leg, using an analytical computer program, areas of interest are identified in the tendon, muscle parts of the veins of the leg and the popliteal vein. The time of evacuation of the radiopharmaceutical from the MVP of the leg is estimated - the average transport time of the isotope.",[16,9,20],{"type":25,"name":30,"description":31,"armGroupLabels":32,"otherNames":10},"single-photon emission computed tomography","SPECT of the pelvic veins with in vivo-labelled red blood cells (RBCs). For radionuclide assessment of the state of the pelvic veins, 2 ml of Perfotech solution is injected into the cubital vein for subsequent \"labeling\" of red blood cells in vivo. In 20 minutes. 370 MBq of 99mTc-pertechnetate is injected into one of the veins of the dorsum of the foot and radionuclide venoscintigraphy is performed according to the method presented above. 20 minutes after the administration of the radiopharmaceutical and the venography, SPECT of the pelvic veins is performed. Tomography of the distribution of labeled erythrocytes in the pelvic veins is carried out in a circular orbit with the gamma camera detector rotated 360°. The analysis of the obtained information is carried out using the standard ECT Protocol software package, which allows obtaining sections in 3 projections (sagittal, transversal and coronal) with a slice step of 8 mm.",[16,9,20],[34],{"name":35,"affiliation":5,"role":36},"Natalia V Koroleva, PhD","STUDY_CHAIR",[38,43],{"name":39,"role":40,"phone":41,"phoneExt":10,"email":42},"Sergey G Gavrilov, MD, PhD","CONTACT","+79169299947","gavriloffsg@mail.ru",{"name":44,"role":40,"phone":45,"phoneExt":10,"email":46},"Anatoly V Karalkin, MD, PhD","+79166196821","avkrar@list.ru",[48],{"facility":49,"status":50,"city":51,"state":10,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Ananstsia Grishenkova","RECRUITING","Moskva","119049","Russia","RU",{"type":56,"coordinates":57},"Point",[58,59],32.16579,56.91775,{"lat":59,"lon":58},[62],{"name":63,"role":40,"phone":64,"phoneExt":10,"email":65},"Ananstsia S Grishenkova, PhD","+79162851112","ngrishenkova@rambler.ru",{"type":67,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Sergey Gavrilov, MD, PhD","Clinical Professor","100525663","study-of-venous-outflow-from-the-lower-limbs-in-patients-with-pelvic-varicosities-100525663",false,"NCT06124664","Study of Venous Outflow From the Lower Limbs in Patients With Pelvic Varicosities","Study of Venous Outflow From the Lower Limbs in Patients With Pelvic Varicosities as a New Strategy for Compression Treatment of Pelvic Varicose Veins and Varicose Veins of the Lower Limb","Inclusion Criteria:\n\n* Patient age from 18 to 40 years;\n* Presence of pelvic varicose veins according to DUS data;\n* Reflux in the pelvic veins for more than 1 second before this DUS;\n* Reflux in the superficial veins of the lower limbs.\n\nExclusion Criteria:\n\n* Menopause;\n* Pregnancy;\n* Postthrombotic disease;\n* Suspicion of May-Turner syndrome;\n* Ultrasound signs of nutcracker syndrome","FEMALE","18 Years","40 Years",{"count":81,"type":82},90,"ESTIMATED","OBSERVATIONAL","Compression therapy is basic treatment for chronic venous disease (CVD) of the lower limbs. Numerous studies have demonstrated the efficacy and safety of compression therapy in relieving symptoms such as pain, venous edema, leg heaviness and fatigue, as well as accelerating the healing of venous ulcers. It has been established that сompression therapy is indicated for patients with both minimally expressed manifestations of CVD and severe forms of the disease. At the same only one study has been conducted to assess the correction of venous outflow from the lower limbs and pelvis in patients with pelvic varicose vein (PVV) and pelvic congestion syndrome (PCS). However, the incidence of this pathology ranges from 15 to 30% in the female population. The cost to the healthcare system of treating these patients in the United States exceeds $2 billion. To date, the options and indications for compression therapy in patients with concomitant PVV and CVD have not been defined. The rational use of compression in this cohort of patients may contribute to the improvement of effective conservative treatment. In addition, inappropriate prescription of compression to patients with pelvic venous disease (which can be observed in real clinical practice) may discredit this simple, effective and safe therapeutic method. In addition, the research devoted to the problem of compression treatment of PVV will contribute to the development of new special compression products aimed at accelerating venous outflow from the pelvic organs. It can be assumed that this will serve as a stimulus for obtaining new data on the therapeutic effects of compression and create conditions for the creation of new technological directions in the production of compression knitwear.",[86,87,88,89],"Pelvic Varices","Varicose Veins of Lower Limb","Pelvic Pain Syndrome","Pelvic Congestive Syndrome",[91,92,93,94,95,30],"pelvic varicose vein","venous outflow","chronic venous disease","compression treatment","duplex ultrasound","2024-12-25",{"date":98,"type":99},"2024-12-27","ACTUAL",{"date":101,"type":99},"2023-05-12",{"date":96,"type":82},{"name":5,"class":6},1]