[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100362256":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":32,"responsibleParty":67,"collaborators":69,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":10,"enrollmentInfo":81,"targetDuration":10,"studyType":84,"phases":10,"briefSummary":85,"conditions":86,"keywords":10,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Institut Pasteur","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"AAV viral transduction",null,"Collection of inner ear cells during a non-conservative surgical approach (translabyrinthine or transotic).",[13],"Other: Peroperative collect of inner ear cells",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"OTHER","Peroperative collect of inner ear cells","After obtaining an informed consent during the preoperative medical visit, and if a non-conservative approach (translabyrinthine or transotic) is decided, the collect of inner ear cells will be performed during surgical approach.\n\nThe sample will be collect in a sterile tube, and carried to the laboratory were it will be placed bon cell culture.",[9],[21],{"name":22,"affiliation":5,"role":23},"Ghizlene Lahlou","STUDY_DIRECTOR",[25,29],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","33 1 45688891","ghizlene.lahlou@pasteur.fr",{"name":30,"role":26,"phone":10,"phoneExt":10,"email":31},"Saaid Safieddine","saaid.safieddine@pasteur.fr",[33,53],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Hôpital de Bicêtre","RECRUITING","Le Kremlin-Bicêtre","Île-de-France Region","94270","France","FR",{"type":42,"coordinates":43},"Point",[44,45],2.36073,48.81471,{"lat":45,"lon":44},[48,51],{"name":49,"role":26,"phone":10,"phoneExt":10,"email":50},"Jérôme Nevoux, MD","jerome.nevoux@aphp.fr",{"name":49,"role":52,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"facility":54,"status":35,"city":55,"state":37,"zip":56,"country":39,"countryCode":40,"cosmosGeoPoint":57,"geoPoint":61,"contacts":62},"Hôpital Pitié-Salpétrière","Paris","75015",{"type":42,"coordinates":58},[59,60],2.3488,48.85341,{"lat":60,"lon":59},[63,66],{"name":64,"role":26,"phone":10,"phoneExt":10,"email":65},"Yann Nguyen, MD","yann.nguyen@aphp.fr",{"name":64,"role":52,"phone":10,"phoneExt":10,"email":10},{"type":68,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[70],{"name":71,"class":16},"Assistance Publique - Hôpitaux de Paris","100362256","study-of-viral-transduction-of-human-auditory-sensory-cells-for-the-development-of-gene-therapy-100362256",false,"NCT03996824","Study of Viral Transduction of Human Auditory Sensory Cells for the Development of Gene Therapy","TREATGENE","Inclusion Criteria:\n\n* Patient ≥ 18 years old\n* Operative indication for a non-conservative resection of vestibular schwannoma, decided by the surgeon in accordance with the patient\n* Informed consent obtained\n* Patients with a french social protection (AME excluded)\n\nExclusion Criteria:\n\n* Intravestibular or intra-cochlear extension of the tumor\n* Pregnant woman\n* Patient with administrative control\n* Medical contra-indication","ALL","18 Years",{"count":82,"type":83},100,"ESTIMATED","OBSERVATIONAL","Gene therapy is a promising strategy to treat hearing loss and vestibular disorders, and Associated adenovirus (AAV) is shown as a good viral vector for inner ear therapy in animal models.\n\nThis study aims to study in vitro viral transduction of AAV in human inner ear cells, collected during non-conservative surgeries for vestibular schwannoma.",[87],"Hearing Loss, Sensorineural","2024-09-10",{"date":90,"type":91},"2024-09-19","ACTUAL",{"date":93,"type":91},"2019-02-19",{"date":95,"type":83},"2027-02-18",{"name":5,"class":6},2]