[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586605":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":15,"locations":7,"responsibleParty":24,"collaborators":7,"id":27,"slug":28,"hasResults":29,"nctId":30,"briefTitle":31,"officialTitle":32,"acronym":7,"eligibilityCriteria":33,"healthyVolunteers":29,"sex":34,"minAge":35,"maxAge":36,"enrollmentInfo":37,"targetDuration":7,"studyType":40,"phases":7,"briefSummary":41,"conditions":42,"keywords":46,"overallStatus":55,"whyStopped":7,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":7},{"fullName":5,"class":6},"Second Hospital of Shanxi Medical University","OTHER",null,[9,12],{"name":10,"affiliation":5,"role":11},"Honglin Dong","PRINCIPAL_INVESTIGATOR",{"name":13,"affiliation":5,"role":14},"Ruijing Zhang","STUDY_DIRECTOR",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":7,"email":20},"Yijie Ning","CONTACT","15735010056","N15735010056@163.com",{"name":22,"role":18,"phone":7,"phoneExt":7,"email":23},"Liuming Shi","shiliuming228@163.com",{"type":25,"investigatorFullName":17,"investigatorTitle":26,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"SPONSOR_INVESTIGATOR","Doctor of vascular surgery","100586605","study-on-pad-and-cas-based-on-omics-and-imaging-100586605",false,"NCT06917547","Study on PAD and CAS Based on Omics and Imaging","Study on the Pathogenesis of PAD and CAS Based on Multi-omics Analysis and Multi-modal Imaging Technology","Inclusion Criteria:\n\n1. The study subjects are inpatients from the Department of Vascular Surgery at the Second Hospital of Shanxi Medical University.\n2. Males or females aged between 18 and 85 years.\n3. Diagnosed with Peripheral Artery Disease (PAD) or Carotid Artery Stenosis (CAS).\n4. Participants are conscious, fully informed about the study content, and have signed the informed consent form, agreeing to participate in this study.\n\nExclusion Criteria:\n\n1. Non-atherosclerotic stenosis (e.g., vasculitis or dissection).\n2. PAD patients who have previously undergone interventional treatments (e.g., balloon angioplasty or stent placement) and\u002For surgical procedures.\n3. Patients with heart failure classified as NYHA Class II-IV or those with a history of coronary artery disease.\n4. Patients with acute infections, tumors, severe arrhythmias, psychiatric disorders, or drug\u002Falcohol addiction.\n5. Significant liver dysfunction or a history of liver diseases, including: Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels exceeding twice the upper limit of normal. History of cirrhosis, hepatic encephalopathy, esophageal varices, or portosystemic shunt.\n6. Significant renal dysfunction or a history of kidney diseases, including: Serum creatinine levels exceeding 1.5 times the upper limit of normal. History of dialysis or nephrotic syndrome.\n7. Pregnant women, those planning to become pregnant, or breastfeeding women.\n8. Participation in other clinical trials within the past 3 months.\n9. Refusal to sign the informed consent form or participate in this study.","ALL","18 Years","85 Years",{"count":38,"type":39},100,"ESTIMATED","OBSERVATIONAL","This study aims to investigate the pathogenesis of Peripheral Artery Disease (PAD) and Carotid Artery Stenosis (CAS) using a comprehensive multi-omics and multi-modal imaging approach. The study will enroll patients diagnosed with PAD or CAS and perform advanced imaging techniques, including NIR-II Imaging, DUS-based V-flow Imaging, and Laser Speckle Imaging, to assess vascular structure and function. Simultaneously, single-cell transcriptomics, metabolomics, lipidomics, and proteomics analyses will be conducted on patient samples to identify key molecular targets and pathways involved in disease progression. Machine learning algorithms will be employed to integrate imaging and multi-omics data, enabling the development of predictive models for more accurate disease diagnosis and stratification. The findings from this study are expected to provide novel insights into the molecular mechanisms underlying PAD and CAS and contribute to the development of personalized therapeutic strategies.",[43,44,45],"Peripheral Artery Disease","Carotid Artery Stenosis","Artery Stenosis",[47,44,48,49,50,51,52,53,54],"Peripheral artery disease","NIR-II Imaging","V-flow Imaging","Laser Speckle Imaging","Single-cell transcriptomics","Proteomics","Lipidomics","Metabolomics","NOT_YET_RECRUITING","2025-03-31",{"date":58,"type":59},"2025-04-08","ACTUAL",{"date":61,"type":39},"2025-04-01",{"date":63,"type":39},"2025-10-01",{"name":17,"class":6}]