[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552799":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":27,"locations":32,"responsibleParty":299,"collaborators":301,"id":305,"slug":306,"hasResults":307,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":311,"eligibilityCriteria":312,"healthyVolunteers":307,"sex":313,"minAge":314,"maxAge":10,"enrollmentInfo":315,"targetDuration":10,"studyType":318,"phases":10,"briefSummary":319,"conditions":320,"keywords":323,"overallStatus":56,"whyStopped":10,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":336},{"fullName":5,"class":6},"Universitaire Ziekenhuizen KU Leuven","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Relapsed or refractory multiple myeloma patients",null,"Patients aged 18 years or older diagnosed with relapsed or refractory multiple myeloma, who received at least 3 prior lines of treatment. They should be refractory to at least 1 proteasome inhibitor, at least 1 immunomodulatory agent, and an anti-CD38 monoclonal antibody. After confirmation of disease progression, the patients will start treatment with teclistamab per routine clinical care or will have started with teclistamab treatment ≤14 days before intended screening visit",[13],"Drug: Teclistamab",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","Teclistamab","Intervention is part of standard clinical care, as Tecvayli\u002FTeclistamab is reimbursed for this group of patients.",[9],[21],"Tecvayli",[23],{"name":24,"affiliation":25,"role":26},"Michel Delforge, MD, PhD","UZ Leuven Gasthuisberg","PRINCIPAL_INVESTIGATOR",[28],{"name":24,"role":29,"phone":30,"phoneExt":10,"email":31},"CONTACT","+32 16 34 68 80","michel.delforge@uzleuven.be",[33,54,71,88,104,120,137,153,161,178,195,206,222,239,252,269,285],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Imelda","NOT_YET_RECRUITING","Bonheiden","Antwerpen","2820","Belgium","BE",{"type":42,"coordinates":43},"Point",[44,45],4.54714,51.02261,{"lat":45,"lon":44},[48,52],{"name":49,"role":29,"phone":50,"phoneExt":10,"email":51},"Ann Pauwels","+32 15 50 46 25","sec@imelda.be",{"name":53,"role":26,"phone":10,"phoneExt":10,"email":10},"Helena Maes, MD",{"facility":55,"status":56,"city":57,"state":37,"zip":58,"country":39,"countryCode":40,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"Universitair Ziekenhuis Antwerpen (UZA)","RECRUITING","Edegem","2500",{"type":42,"coordinates":60},[61,62],4.44504,51.15662,{"lat":62,"lon":61},[65,69],{"name":66,"role":29,"phone":67,"phoneExt":10,"email":68},"Anouk Smits","+32 38 21 53 98","studies.hematologie@uza.be",{"name":70,"role":26,"phone":10,"phoneExt":10,"email":10},"Ann Van de Velde, MD, PhD",{"facility":72,"status":56,"city":73,"state":74,"zip":75,"country":39,"countryCode":40,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Grand Hôpital de Charleroi","Charleroi","Henegouwen","6000",{"type":42,"coordinates":77},[78,79],4.44448,50.41136,{"lat":79,"lon":78},[82,86],{"name":83,"role":29,"phone":84,"phoneExt":10,"email":85},"Christy Vanderperren","+32 71 10 47 60","christy.VANDERPERREN@ghdc.be",{"name":87,"role":26,"phone":10,"phoneExt":10,"email":10},"Géraldine Verstraete, MD",{"facility":89,"status":56,"city":90,"state":74,"zip":91,"country":39,"countryCode":40,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"EpiCURA","Hornu","7301",{"type":42,"coordinates":93},[94,95],3.82736,50.4328,{"lat":95,"lon":94},[98,102],{"name":99,"role":29,"phone":100,"phoneExt":10,"email":101},"Sophie Viart","+32 65 61 44 89","sophie.viart@epicura.be",{"name":103,"role":26,"phone":10,"phoneExt":10,"email":10},"Géraldine Claes, MD",{"facility":105,"status":56,"city":106,"state":74,"zip":107,"country":39,"countryCode":40,"cosmosGeoPoint":108,"geoPoint":112,"contacts":113},"CHU Ambroise Paré","Mons","7000",{"type":42,"coordinates":109},[110,111],3.95229,50.45413,{"lat":111,"lon":110},[114,118],{"name":115,"role":29,"phone":116,"phoneExt":10,"email":117},"Recherche Clinique","+32 65 41 75 01","recherche.clinique@helora.be",{"name":119,"role":26,"phone":10,"phoneExt":10,"email":10},"Caroline Jacquy, MD, PhD",{"facility":121,"status":56,"city":122,"state":123,"zip":124,"country":39,"countryCode":40,"cosmosGeoPoint":125,"geoPoint":129,"contacts":130},"Jessa Ziekenhuis","Hasselt","Limburg","3500",{"type":42,"coordinates":126},[127,128],5.33781,50.93106,{"lat":128,"lon":127},[131,135],{"name":132,"role":29,"phone":133,"phoneExt":10,"email":134},"Elke Van Campenhout","+32 11 33 79 94","elke.vancampenhout@jessazh.be",{"name":136,"role":26,"phone":10,"phoneExt":10,"email":10},"Koen Theunissen, MD",{"facility":138,"status":56,"city":139,"state":139,"zip":140,"country":39,"countryCode":40,"cosmosGeoPoint":141,"geoPoint":145,"contacts":146},"CHR Citadelle","Liège","4000",{"type":42,"coordinates":142},[143,144],5.56749,50.63373,{"lat":144,"lon":143},[147,151],{"name":148,"role":29,"phone":149,"phoneExt":10,"email":150},"Sophie Ledant","+32 43 21 83 51","sophie.ledant@citadelle.be",{"name":152,"role":26,"phone":10,"phoneExt":10,"email":10},"Michelle Pirotte, MD",{"facility":154,"status":56,"city":139,"state":139,"zip":140,"country":39,"countryCode":40,"cosmosGeoPoint":155,"geoPoint":157,"contacts":158},"CHU Liège",{"type":42,"coordinates":156},[143,144],{"lat":144,"lon":143},[159,160],{"name":148,"role":29,"phone":149,"phoneExt":10,"email":150},{"name":152,"role":26,"phone":10,"phoneExt":10,"email":10},{"facility":162,"status":56,"city":163,"state":164,"zip":165,"country":39,"countryCode":40,"cosmosGeoPoint":166,"geoPoint":170,"contacts":171},"CHU UCL Namur","Yvoir","Namur","5530",{"type":42,"coordinates":167},[168,169],4.88059,50.3279,{"lat":169,"lon":168},[172,176],{"name":173,"role":29,"phone":174,"phoneExt":10,"email":175},"Benoit Martin","+32 81 42 38 38","B.martin@chuuclnamur.uclouvain.be",{"name":177,"role":26,"phone":10,"phoneExt":10,"email":10},"Julien Depaus, MD",{"facility":179,"status":56,"city":180,"state":181,"zip":182,"country":39,"countryCode":40,"cosmosGeoPoint":183,"geoPoint":187,"contacts":188},"Algemeen Ziekenhuis Maria Middelares (AZMM)","Ghent","Oost-Vlaanderen","9000",{"type":42,"coordinates":184},[185,186],3.71667,51.05,{"lat":186,"lon":185},[189,193],{"name":190,"role":29,"phone":191,"phoneExt":10,"email":192},"Mieke Van Den Berghe","+32 92 46 95 18","Mieke.VanDenBerghe@mijnziekenhuis.be",{"name":194,"role":26,"phone":10,"phoneExt":10,"email":10},"Veerle Galle, MD",{"facility":196,"status":56,"city":180,"state":181,"zip":182,"country":39,"countryCode":40,"cosmosGeoPoint":197,"geoPoint":199,"contacts":200},"Universitair Ziekenhuis Gent (UZ Gent)",{"type":42,"coordinates":198},[185,186],{"lat":186,"lon":185},[201,204],{"name":202,"role":29,"phone":10,"phoneExt":10,"email":203},"Studies Hematologie","studies.hematologie@uzgent.be",{"name":205,"role":26,"phone":10,"phoneExt":10,"email":10},"Nicolas Kint, MD, PhD",{"facility":207,"status":56,"city":208,"state":181,"zip":209,"country":39,"countryCode":40,"cosmosGeoPoint":210,"geoPoint":214,"contacts":215},"Vitaz","Sint-Niklaas","9100",{"type":42,"coordinates":211},[212,213],4.1437,51.16509,{"lat":213,"lon":212},[216,220],{"name":217,"role":29,"phone":218,"phoneExt":10,"email":219},"Isabel de Brabander","+32 37 60 25 73","isabel.debrabander@vitaz.be",{"name":221,"role":26,"phone":10,"phoneExt":10,"email":10},"Isabelle Vande Broek, MD, PhD",{"facility":223,"status":56,"city":224,"state":225,"zip":226,"country":39,"countryCode":40,"cosmosGeoPoint":227,"geoPoint":231,"contacts":232},"Institut Jules Bordet","Brussels","Vlaams-Brabant","1070",{"type":42,"coordinates":228},[229,230],4.34878,50.85045,{"lat":230,"lon":229},[233,237],{"name":234,"role":29,"phone":235,"phoneExt":10,"email":236},"Bénédicte Vucic","+32 25 41 36 47","benedicte.vucic@hubruxelles.be",{"name":238,"role":26,"phone":10,"phoneExt":10,"email":10},"Marie Vercruyssen, MD",{"facility":240,"status":56,"city":224,"state":225,"zip":241,"country":39,"countryCode":40,"cosmosGeoPoint":242,"geoPoint":244,"contacts":245},"UCL Saint Luc","1200",{"type":42,"coordinates":243},[229,230],{"lat":230,"lon":229},[246,250],{"name":247,"role":29,"phone":248,"phoneExt":10,"email":249},"Charlene Mouafo","+32 27 64 17 36","charlene.mouafo@saintluc.uclouvain.be",{"name":251,"role":26,"phone":10,"phoneExt":10,"email":10},"Marie-Christiane Vekemans, MD",{"facility":253,"status":56,"city":254,"state":255,"zip":256,"country":39,"countryCode":40,"cosmosGeoPoint":257,"geoPoint":261,"contacts":262},"AZ Groeninge","Kortrijk","West-Vlaanderen","8500",{"type":42,"coordinates":258},[259,260],3.26487,50.82803,{"lat":260,"lon":259},[263,267],{"name":264,"role":29,"phone":265,"phoneExt":10,"email":266},"Ellen Callens","+32 56 63 39 00","ellen.callens@azgroeninge.be",{"name":268,"role":26,"phone":10,"phoneExt":10,"email":10},"Alexander Salembier, MD",{"facility":270,"status":56,"city":271,"state":255,"zip":272,"country":39,"countryCode":40,"cosmosGeoPoint":273,"geoPoint":277,"contacts":278},"AZ Delta","Roeselare","8800",{"type":42,"coordinates":274},[275,276],3.12269,50.94653,{"lat":276,"lon":275},[279,283],{"name":280,"role":29,"phone":281,"phoneExt":10,"email":282},"Ruth Demeersseman","+32 51 23 75 60","ruth.demeersseman@azdelta.be",{"name":284,"role":26,"phone":10,"phoneExt":10,"email":10},"Rutger Callens, MD",{"facility":25,"status":56,"city":286,"state":10,"zip":287,"country":39,"countryCode":40,"cosmosGeoPoint":288,"geoPoint":292,"contacts":293},"Leuven","3000",{"type":42,"coordinates":289},[290,291],4.70093,50.87959,{"lat":291,"lon":290},[294,297],{"name":295,"role":29,"phone":10,"phoneExt":10,"email":296},"Dimitri Vanhaen","dimitri.vanhaen@uzleuven.be",{"name":298,"role":26,"phone":10,"phoneExt":10,"email":10},"Michel Delforge, MD PhD",{"type":300,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[302],{"name":303,"class":304},"Janssen Pharmaceutica","INDUSTRY","100552799","study-on-the-clinical-efficacy-of-teclistamab-100552799",false,"NCT06477783","Study on the Clinical Efficacy of Teclistamab","Prospective Observational Study on the Clinical Efficacy of Teclistamab in Patients With Relapsed and Refractory Multiple Myeloma in Belgium","TECTONIC","Inclusion Criteria:\n\n* Age 18 years or older\n* Written informed consent\n* Has a diagnosis of relapsed and refractory multiple myeloma\n* Has already received at least three previous treatments\n* Is refractory to at least 1 proteasome inhibitor, at least 1 immunomodulatory agent, and an anti-CD38 monoclonal antibody\n* Evidence of disease progression on the last line of therapy, based on determination of response by the IMWG response criteria\n* Anticipated to start treatment with teclistamab per routine clinical care or has started with teclistamab treatment ≤14 days before intended screening visit\n\nExclusion Criteria:\n\n* Has participated in a teclistamab trial (teclistamab or control arm) or teclistamab Single Patient Request (SPR) program\n* Has started teclistamab treatment \\>14 days before intended screening visit.","ALL","18 Years",{"count":316,"type":317},100,"ESTIMATED","OBSERVATIONAL","The aim of this study is to assess the clinical efficacy and safety of the anti-BCMA\u002FCD3 bispecific antibody teclistamab (Tecvayli®) in a prospective, real-life setting in Belgium.",[321,322],"Multiple Myeloma","Hematologic Diseases",[17,21,324,325,326],"Hematology","Efficacy","Safety","2025-03-11",{"date":329,"type":330},"2025-03-12","ACTUAL",{"date":332,"type":330},"2024-12-01",{"date":334,"type":317},"2027-09",{"name":5,"class":6},17]