[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100565743":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":11,"responsibleParty":35,"collaborators":11,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":11,"eligibilityCriteria":43,"healthyVolunteers":39,"sex":44,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":11,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":58,"overallStatus":63,"whyStopped":11,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":11},{"fullName":5,"class":6},"Nanfang Hospital, Southern Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Fat Graft Combined with Hair Transplantation Group","EXPERIMENTAL",null,[13],"Procedure: Fat grafting combine with hair transplantation",{"label":15,"type":16,"description":11,"interventionNames":17},"Hair Transplantation Group","ACTIVE_COMPARATOR",[18],"Procedure: Hair transplantation",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"PROCEDURE","Fat grafting combine with hair transplantation","Patients enrolled in this experiment will be divided into two groups.The experimental group will have autologous fat tissue harvested during surgery for fat grafting in the patient's alopecia area, and a subsequent hair transplantation will be performed after three months when the transplanted fat has stabilized and survived.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Hair transplantation","Patients enrolled in this experiment will be divided into two groups. The control group will undergo a simple hair transplantation surgery.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"Junrong Cai Cai","CONTACT","86+18565328278","cjr710508@qq.com",{"type":36,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100565743","study-on-the-efficacy-of-autologous-fat-grafting-in-improving-hair-transplantation-outcomes-for-patients-with-localized-scleroderma-related-alopecia-100565743",false,"NCT06646146","Study on the Efficacy of Autologous Fat Grafting in Improving Hair Transplantation Outcomes for Patients With Localized Scleroderma-Related Alopecia","A Single-Center, Prospective, Randomized Controlled Clinical Study on the Efficacy of Autologous Fat Grafting in Improving Hair Transplantation Outcomes for Patients With Localized Scleroderma-Related Alopecia","Inclusion Criteria:\n\n* 1\\. Patients with clinical symptoms consistent with localized scleroderma (LoSCAT score can be used to assist in diagnosis).\n\n  2\\. Diagnosed with secondary alopecia caused by localized scleroderma. 3. A history of hair loss in the affected area for more than 6 months, with an adequate supply of donor hair.\n\n  4\\. The disease is inactive and has been in a stationary phase for over a year (patients have no ongoing or intermittent hair loss accompanied by local pain, itching, or burning; scalp biopsy indicates no inflammatory cell infiltration, hair follicle orifices have disappeared, and hair follicles are replaced by connective tissue).\n\n  5\\. The general condition is stable, and the patient can tolerate anesthesia and surgery.\n\n  6\\. BMI is greater than or equal to 17. 7. Age between 18 and 59. 8. The subject and their family are willing and able to comply with postoperative care and follow-up requirements.\n\n  9\\. The subject and their family have given informed consent and have signed the informed consent form.\n\nExclusion Criteria:\n\n1. Hair loss area exceeds one-third of the scalp.\n2. Infection of the scalp soft tissue.\n3. Suffering from psychiatric disorders, hematologic diseases, immune deficiencies, abnormalities in liver or kidney function, severe hypertension, severe diabetes, and other contraindications for surgery.\n4. Women who are pregnant or breastfeeding.\n5. BMI is less than 17, making it impossible to obtain sufficient fat.\n6. Received new vasodilator or immunosuppressive drug treatment within the past 3 months.\n7. Applied topical ointments to the surgical area within the past 2 weeks.\n8. Positive for HIV, HBV, HCV, HTLV-1 or -2, or syphilis.\n9. Patients with a history of tumor formation in the last 5 years.\n10. Patients with a prednisolone intake greater than 10 mg\u002Fday. Patients deemed unsuitable for participation in this trial by the investigator's judgment.","ALL","18 Years","59 Years",{"count":48,"type":49},40,"ESTIMATED","INTERVENTIONAL",[52],"NA","Investigating the efficacy and safety of autologous fat grafting combined with hair transplantation for the treatment of hair loss in patients with localized scleroderma.\"",[55,56,57],"Fat Grafting","Hair Transplantation","Localized Scleroderma",[59,60,61,62],"fat grafting","localized scleroderma","alopecia","hair transplantation","NOT_YET_RECRUITING","2024-10-16",{"date":66,"type":67},"2024-10-17","ACTUAL",{"date":69,"type":49},"2024-10-31",{"date":71,"type":49},"2026-05-01",{"name":5,"class":6}]