[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100527054":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":31,"locations":38,"responsibleParty":56,"collaborators":25,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":25,"enrollmentInfo":68,"targetDuration":25,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":25,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"University Health Network, Toronto","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1: tidal volume delivered at 6 ml\u002Fkg for 3-5 minutes, followed by 12ml\u002Fkg for 3-5 minutes","EXPERIMENTAL","The clinical MRI examination will be obtained before commencing with the study protocol. The study protocol will commence once the scheduled MRI scan is finished. The study-related procedures will add 10 minutes after the scheduled MRI scans are finished with two different tidal volumes with maintaining isocapnia and isooxia.\n\nStudy procedure: tidal volume delivered at 6 ml\u002Fkg for 5 minutes, followed by 12ml\u002Fkg for 5 minutes",[13],"Device: Tidal Volume set on ventilator",{"label":15,"type":16,"description":17,"interventionNames":18},"Group 2: tidal volume delivered at 12 ml\u002Fkg for 3-5 minutes, followed by 6ml\u002Fkg for 3-5 minutes","ACTIVE_COMPARATOR","The clinical MRI examination will be obtained before commencing with the study protocol. The study protocol will commence once the scheduled MRI scan is finished. The study-related procedures will add 10 minutes after the scheduled MRI scans are finished with two different tidal volumes with maintaining isocapnia and isooxia.\n\nStudy procedure: tidal volume delivered at 12 ml\u002Fkg for 5 minutes, followed by 6ml\u002Fkg for 5 minutes",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Tidal Volume set on ventilator","Mechanically ventilated patients who are undergoing MRI examinations under general anesthesia in isocapnic and isoxic conditions will have brain activity investigated under two different tidal volumes, 6 ml\u002Fkg and 12 ml\u002Fkg applied for 3-5 minutes.",[9,15],null,[27],{"name":28,"affiliation":29,"role":30},"Ewan Goligher, MD","University Health Networ","PRINCIPAL_INVESTIGATOR",[32],{"name":33,"role":34,"phone":35,"phoneExt":36,"email":37},"Rongyu ( Cindy) Jin","CONTACT","416-340-4800","7613","rongyu.jin@uhn.ca",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Toronto General Hospital","RECRUITING","Toronto","Ontario","M5G 2N2","Canada","CA",{"type":48,"coordinates":49},"Point",[50,51],-79.39864,43.70643,{"lat":51,"lon":50},[54],{"name":55,"role":34,"phone":35,"phoneExt":36,"email":37},"Rongyu (Cindy) Jin",{"type":57,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100527054","study-to-investigate-an-association-between-brain-activity-and-tidal-volume-in-humans-batman-100527054",false,"NCT06142773","Study to Investigate an Association Between Brain Activity and Tidal Volume in Humans (BATMAN)","Study to Investigate an Association Between Brain Activity and Tidal Volume in Humans (BATMAN) - a Pilot Study","BATMAN","Inclusion Criteria:\n\n1. Patients scheduled to undergo an MRI scan of their head under general anesthesia\n2. Age \\> 18 years\n\nExclusion Criteria:\n\n1. Stroke, and\u002For brain tumor in the regions of interest that has not been diagnosed before the MRI scan\n2. Previous medical history of dementia\n3. Previous medical history of brain surgery\n4. Acute or chronic spinal cord Injury\n5. Previous Vagotomy\n6. Phrenic nerve injury","ALL","18 Years",{"count":69,"type":70},10,"ESTIMATED","INTERVENTIONAL",[73],"NA","The communication between the lungs and the brain has drawn a lot of attention recently. Animal studies have shown that the breathing cycle is coupled with brain activity, showing that the greater the volume of air delivered to the lungs via a breathing machine greater the brain activity and also the greater the injury to the brain cells.\n\nThere is no study in humans that investigates the physiological communication between the volume of air delivered to the lungs and brain activity. This is important because really sick patients receive breathing assistance using breathing machines to keep their oxygen levels within a normal range. Although these machines are life-saving tools, they might result in brain cell injury, leading to cognitive impairment. So, establishing the existence of a physiological communication between the volume of air delivered using these breathing machines and brain activity is the first step to investigating therapies to prevent brain cell injury due to the use of breathing machines to assist breathing.",[76],"Ventilation Therapy; Complications","2025-03-03",{"date":79,"type":80},"2025-03-06","ACTUAL",{"date":82,"type":80},"2023-11-30",{"date":84,"type":70},"2026-12-31",{"name":5,"class":6},1]