[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638548":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":15,"collaborators":10,"id":17,"slug":18,"hasResults":19,"nctId":20,"briefTitle":21,"officialTitle":22,"acronym":10,"eligibilityCriteria":23,"healthyVolunteers":24,"sex":25,"minAge":26,"maxAge":10,"enrollmentInfo":27,"targetDuration":30,"studyType":31,"phases":10,"briefSummary":32,"conditions":33,"keywords":38,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":10},{"fullName":5,"class":6},"Vrije Universiteit Brussel","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Subacute stroke",null,"Stroke survivors will be recruited from Brussels University Hospital (Brussels, Belgium). Patients who have a first-ever stroke, ≥18 years, subacute phase: 1 week to 6 months post-stroke, quadriceps (hemiplegic side) strength ≤3\u002F5 (Medical Research Council (MRC)), and Montreal Cognitive Assessment (MoCA) ≥21 will be included. Exclusion criteria include a history of a previous stroke, severe spasticity (Modified Ashworth Scale (MAS) 3-4 in quadriceps\u002Fhamstrings), other neurological, motor, musculoskeletal, or orthopedic conditions affecting trunk stability and lower limb mobility, non-cerebral strokes (e.g., brainstem, cerebellar), or dementia (MoCA ≤20), and current or former athletes.",{"label":13,"type":10,"description":14,"interventionNames":10},"Healthy participants","Healthy age-matched controls ≥18 years and Montreal Cognitive Assessment (MoCA) ≥21 will be included. Exclusion criteria include other neurological, motor, musculoskeletal, or orthopedic conditions affecting trunk stability and lower limb mobility, non-cerebral strokes (e.g., brainstem, cerebellar), or dementia (MoCA ≤20), and current or former athletes.",{"type":16,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100638548","studying-fatigue-and-movement-after-stroke-100638548",false,"NCT07594938","Studying Fatigue and Movement After Stroke","Exploring Neuromuscular Fatigue in Stroke Survivors: Understanding Central-Peripheral Interaction","Inclusion Criteria:\n\nStroke survivors will be recruited from Brussels University Hospital (Brussels, Belgium). Patients who have a first-ever stroke, ≥18 years, subacute phase: 1 week to 6 months post-stroke, quadriceps (hemiplegic side) strength ≤3\u002F5 (Medical Research Council (MRC)), and Montreal Cognitive Assessment (MoCA) ≥21 will be included.\n\nExclusion Criteria:\n\nExclusion criteria include a history of a previous stroke, severe spasticity (Modified Ashworth Scale (MAS) 3-4 in quadriceps\u002Fhamstrings), other neurological, motor, musculoskeletal, or orthopedic conditions affecting trunk stability and lower limb mobility, non-cerebral strokes (e.g., brainstem, cerebellar), or dementia (MoCA ≤20), and current or former athletes. Athletes are defined as individuals who participated in organized competitive sports and engaged in structured training ≥3 sessions per week for ≥1 year within the 5 years preceding stroke. Control participants will be excluded if they meet the same exclusion criteria.",true,"ALL","18 Years",{"count":28,"type":29},120,"ESTIMATED","1 Day","OBSERVATIONAL","The goal of this observational study is to learn how neuromuscular fatigue develops after stroke and how changes in brain activity, muscle activity, and their interaction contribute to reduced motor performance in stroke survivors compared to healthy individuals. The study will include adults with a first-ever stroke in the subacute phase and age-matched healthy volunteers.\n\nThe main questions it aims to answer are:\n\n* How does neuromuscular fatigue develop during repeated muscle contractions after stroke compared to healthy individuals?\n* How do brain activity, muscle activity, and brain-muscle interaction change during fatigue after stroke?\n\nResearchers will compare stroke participants and healthy control participants to determine whether fatigue-related changes are more strongly associated with altered brain activity, altered muscle activity, or disrupted brain-muscle communication after stroke.\n\nParticipants will:\n\n* Perform repeated leg muscle contractions until fatigue while seated in an experimental setup\n* Wear non-invasive sensors to record brain activity (EEG) and muscle activity (EMG) during the task\n* Complete the study during a single experimental session in which fatigue-related changes will be measured throughout the task",[34,35,36,37],"Stroke","Cerebro-vascular Accident","Ischemia Stroke","Hemorrhage Stroke",[39,40,41,42,43,44],"fatigue","electroencephalography","EEG","electromyography","EMG","stroke","NOT_YET_RECRUITING","2026-05-18",{"date":48,"type":49},"2026-05-19","ACTUAL",{"date":51,"type":29},"2026-09-01",{"date":53,"type":29},"2029-10-31",{"name":5,"class":6}]