[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638604":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":59,"collaborators":26,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":26,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"the experimental group","EXPERIMENTAL","real stimulation",[13],"Device: real transcranial temporal interference stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"the control group","SHAM_COMPARATOR","sham stimulation",[19],"Device: sham transcranial temporal interference stimulation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","real transcranial temporal interference stimulation","tTIS was targeted at the bilateral STN, with stimulation delivered once daily for 20 minutes per session, for a total of five consecutive days.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"sham transcranial temporal interference stimulation","The sham stimulation is administered using the same procedure as the real tTIS.",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Xiaoying Zhu, MD","CONTACT","86-13817659260","docxiaoying@163.com",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Jingtao Feng, MD","86-18651285832","fengjt0919@163.com",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Shanghai General Hospital","RECRUITING","Shanghai","Shanghai Municipality","200080","China","CN",{"type":51,"coordinates":52},"Point",[53,54],121.45806,31.22222,{"lat":54,"lon":53},[57,58],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Xiaoying Zhu","Associate Professor","100638604","subthalamic-nucleus-targeted-transcranial-temporal-interference-stimulation-for-motor-and-non-motor-symptoms-in-parkinsons-disease-100638604",false,"NCT07625540","Subthalamic Nucleus-Targeted Transcranial Temporal Interference Stimulation for Motor and Non-Motor Symptoms in Parkinson's Disease","Study on the Efficacy and Safety of Subthalamic Nucleus (STN)-Targeted Transcranial Temporal Interference Stimulation (tTIS) for Motor and Non-Motor Symptoms in Parkinson's Disease (PD): A Randomized, Double-Blind, Controlled Exploratory Trial","STN-tTIS-PD","Inclusion Criteria:\n\n* Aged 50-85 years, male or female.\n* Diagnosed with \"clinically established\" or \"clinically probable\" Parkinson's disease according to the 2015 MDS Clinical Diagnostic Criteria for Parkinson's Disease.\n* Hoehn-Yahr stage ≥ 2, and judged by the investigator to be able to cooperate in completing scale-based assessments and MRI examinations.\n* Stable regimen of anti-Parkinsonian medication for at least 4 weeks before enrollment, and agreement to maintain a stable regimen during the main study phase unless medically necessary to change.\n* Written informed consent signed by the study participant.\n\nExclusion Criteria:\n\n* Non-primary Parkinson's disease or other parkinsonism \u002F atypical parkinsonism.\n* Previous receipt of invasive neuromodulation therapies such as deep brain stimulation (DBS) or other intracranial implantation\u002Fstereotactic brain surgery.\n* Presence of contraindications or high-risk conditions for transcranial electrical stimulation (e.g., incompatible metal implants\u002Fimplantable electrical stimulation devices, etc.), or judged by the investigator as unsuitable to receive transcranial electrical stimulation.\n* Receipt of non-invasive neuromodulation interventions such as transcranial magnetic stimulation or transcranial electrical stimulation within the past six months.\n* Presence of contraindications to MRI or inability to tolerate MRI examination.\n* Significant cognitive impairment or severe psychiatric symptoms that prevent completion of assessments or result in poor compliance.\n* New initiation or dose adjustment of medications or treatments that significantly affect sleep architecture\u002Fconsciousness status within the past 4 weeks.\n* History of epilepsy.\n* Pregnancy or breastfeeding.\n* Any other condition judged by the investigator as unsuitable for participation in the study.","ALL","50 Years","85 Years",{"count":75,"type":76},32,"ESTIMATED","INTERVENTIONAL",[79],"NA","Transcranial temporal interference stimulation (tTIS) is a non-invasive deep brain stimulation method. This study aims to comprehensively explore the efficacy and safety of bilateral subthalamic nucleus (STN) tTIS on motor and non-motor symptoms in patients with Parkinson's disease (PD).",[82],"Parkinson's Disease (PD)",[84,85,86,87,88],"Parkinson's disease","transcranial Temporal Interference Stimulation","subthalamic nucleus","motor symptoms","non-motor symptoms","2026-06-02",{"date":91,"type":92},"2026-06-04","ACTUAL",{"date":94,"type":92},"2026-05-20",{"date":96,"type":76},"2027-04",{"name":5,"class":6},1]