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These resuscitation efforts are successful in more than 40% of cases. The study population will therefore be divided into two groups: a group of resuscitated SCA victims (SCA group) and a group of non-resuscitated or unsuccessfully resuscitated victims (SCD group).\n\nThe RESOUDRE study is an observational study focusing on individuals who have experienced SCA. Depending on the outcome-whether the individual survives or not-the etiological assessment will differ. While the study design refers to two distinct groups for clarity, they represent a single population, and no statistical comparison between the two groups will be made.",[13],"Genetic: Whole exome sequencing to detect myocardial genetic mutations (SCA group only)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"GENETIC","Whole exome sequencing to detect myocardial genetic mutations (SCA group only)","Whole exome sequencing to detect myocardial genetic mutations",[9],[21],{"name":22,"affiliation":23,"role":24},"Frédéric SCHNELL","Study Principal Investigator","PRINCIPAL_INVESTIGATOR",[26,30],{"name":22,"role":27,"phone":28,"phoneExt":10,"email":29},"CONTACT","0299284133","frederic.schnell@chu-rennes.fr",{"name":31,"role":27,"phone":32,"phoneExt":10,"email":33},"Stéphanie 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GARCIA","rodrigue.garcia@chu-poitiers.fr",{"name":309,"role":27,"phone":10,"phoneExt":10,"email":10},{"facility":313,"status":37,"city":314,"state":10,"zip":315,"country":39,"countryCode":41,"cosmosGeoPoint":316,"geoPoint":320,"contacts":321},"CHU Reims","Reims","51092",{"type":43,"coordinates":317},[318,319],4.02853,49.26526,{"lat":319,"lon":318},[322,325],{"name":323,"role":27,"phone":10,"phoneExt":10,"email":324},"Damien METZ","dmetz@chu-reims.fr",{"name":323,"role":27,"phone":10,"phoneExt":10,"email":10},{"facility":327,"status":37,"city":328,"state":10,"zip":329,"country":39,"countryCode":41,"cosmosGeoPoint":330,"geoPoint":334,"contacts":335},"CHU Rouen","Rouen","76031",{"type":43,"coordinates":331},[332,333],1.09932,49.44313,{"lat":333,"lon":332},[336,339],{"name":337,"role":27,"phone":10,"phoneExt":10,"email":338},"Frédéric ANSELME","Frederic.Anselme@chu-rouen.fr",{"name":337,"role":27,"phone":10,"phoneExt":10,"email":10},{"facility":341,"status":37,"city":342,"state":10,"zip":343,"country":39,"countryCode":41,"cosmosGeoPoint":344,"geoPoint":348,"contacts":349},"CHU Saint-Etienne","Saint-Etienne","42100",{"type":43,"coordinates":345},[346,347],4.39,45.43389,{"lat":347,"lon":346},[350,353],{"name":351,"role":27,"phone":10,"phoneExt":10,"email":352},"Antoine DA COSTA","antoine.dacosta@univ-st-etienne.fr",{"name":351,"role":27,"phone":10,"phoneExt":10,"email":10},{"facility":355,"status":37,"city":356,"state":10,"zip":357,"country":39,"countryCode":41,"cosmosGeoPoint":358,"geoPoint":362,"contacts":363},"CHRU Strasbourg","Strasbourg","67091",{"type":43,"coordinates":359},[360,361],7.74553,48.58392,{"lat":361,"lon":360},[364,367],{"name":365,"role":27,"phone":10,"phoneExt":10,"email":366},"Laurence JESEL-MOREL","Laurence.JESEL-MOREL@chru-strasbourg.fr",{"name":365,"role":27,"phone":10,"phoneExt":10,"email":10},{"facility":369,"status":37,"city":370,"state":10,"zip":371,"country":39,"countryCode":41,"cosmosGeoPoint":372,"geoPoint":376,"contacts":377},"CHU Toulouse","Toulouse","31059",{"type":43,"coordinates":373},[374,375],1.44367,43.60426,{"lat":375,"lon":374},[378,381],{"name":379,"role":27,"phone":10,"phoneExt":10,"email":380},"Philippe MAURY","maury.p@chu-toulouse.fr",{"name":379,"role":27,"phone":10,"phoneExt":10,"email":10},{"facility":383,"status":66,"city":384,"state":10,"zip":385,"country":39,"countryCode":41,"cosmosGeoPoint":386,"geoPoint":390,"contacts":391},"CHRU Tours","Tours","37044",{"type":43,"coordinates":387},[388,389],0.70398,47.39484,{"lat":389,"lon":388},[392,395],{"name":393,"role":27,"phone":10,"phoneExt":10,"email":394},"Fabrice IVANES","F.IVANES@chu-tours.fr",{"name":393,"role":27,"phone":10,"phoneExt":10,"email":10},{"type":397,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100565437","sudden-cardiac-arrest-related-to-sport-in-young-and-value-of-the-genetic-assessment-a-french-prospective-register-100565437",false,"NCT06642168","Sudden Cardiac Arrest Related to Sport in Young and Value of the Genetic Assessment: a French Prospective Register","Registre Prospectif Français Des Morts Subites Chez Des Sportifs Jeunes","RESOUDRE","Inclusion Criteria:\n\n* Victims of SCA:\n\n  * Aged between 12 and 35 years\n  * No known cardiovascular pathology\n  * Experienced a sudden and non-traumatic SCA during or within one hour of participating in sports activities (leisure, training, or competition)\n  * For resuscitated victims (SCA group): A person or legal representative who does not oppose participation in the research after being informed about the study (including individuals, organs, or authorities responsible for assisting or representing them if they are unable to express their wishes).\n  * For non-resuscitated victims (SCD group): A person who has not formally objected to the reuse of their medical data during their lifetime.\n* First-Degree Relatives:\n\n  * A person or legal representative who does not oppose participation in the research after being informed about the study (including individuals, bodies, or authorities responsible for assisting or representing them if they are unable to express their wishes).\n\nNon-Inclusion Criteria:\n\n* For resuscitated SCA cases, individuals weighing less than 20 kg\n* Victims or legal representatives who are subject to legal protection or deprived of their liberty","ALL","12 Years","35 Years",{"count":410,"type":411},80,"ESTIMATED","OBSERVATIONAL","The increased risk of sudden cardiac arrest (SCA) or sudden cardiac death (SCD) related to vigorous physical activity is well-documented. Currently, for young victims (under 35 years) of SCA\u002FSCD, no etiology is found in 40 to 50% of cases after a standard medical assessment, leading to two important consequences. For the victim's family, it is difficult to understand and accept this tragic event, and the risk of it occurring in another family member is a source of concern. Medically, the absence of a known cause limits the ability to effectively prevent such events.\n\nThe RESOUDRE study will be a national, prospective, observational registry of young victims (12-35 years) of sports-related SCA\u002FSCD. All cases will undergo the recommended etiological assessment, including autopsy for SCA cases, along with whole exome genetic analysis and toxicological testing. In the event a genetic pathology is identified, a genetic evaluation will be offered to other family members, and appropriate medical care will be provided if necessary. The results of this study could significantly reduce the number of unexplained sport-related SCA\u002FSCD cases and aid in preventing these incidents among affected families.",[415,416],"Sudden Cardiac Arrest","Sudden Cardiac Death",[418,419,420,421,422,423,424,425,426],"Sport related sudden cardiac arrest","Sport related sudden cardiac death","Young athlete","Etiological Diagnosis","Autopsy","Genetic","Toxicology","Hereditary Cardiac disease","Prevention","2025-01-07",{"date":429,"type":430},"2025-01-08","ACTUAL",{"date":432,"type":430},"2024-10-11",{"date":434,"type":411},"2028-01-11",{"name":5,"class":6},26]