[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624471":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":40,"responsibleParty":53,"collaborators":25,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":25,"enrollmentInfo":66,"targetDuration":25,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":78,"whyStopped":25,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Center for Health Sciences, Serbia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Hydrogen-rich water","EXPERIMENTAL","1.0 L of hydrogen-rich water per day",[13],"Dietary Supplement: Hydrogen-rich water",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","ACTIVE_COMPARATOR","1.0 L of hydrogen-free water per day",[19],"Dietary Supplement: Control",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Hydrogen-rich water (1.0 L per day)",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Hydrogen-free water (1.0 L per day)",[15],[30],{"name":31,"affiliation":32,"role":33},"Nikola Todorovic, PhD","Center for Mitochondrial Medicine","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Sergej Ostojic, MD, PhD","CONTACT","+381112643242","sergej.ostojic@chess.edu.rs",[41],{"facility":42,"status":25,"city":43,"state":25,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":25},"Center for Health Sciences","Belgrade","11000","Serbia","RS",{"type":48,"coordinates":49},"Point",[50,51],20.46513,44.80401,{"lat":51,"lon":50},{"type":54,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100624471","supersaturated-hydrogen-rich-water-for-outpatients-with-persistent-excess-weight-100624471",false,"NCT07410065","Supersaturated Hydrogen-Rich Water for Outpatients With Persistent Excess Weight","Supersaturated Hydrogen-Rich Water for Outpatients With Persistent Excess Weight (HOPE)","HOPE","Inclusion Criteria:\n\n* Age \\> 18 years\n* Body mass index \\> 25.0 kg\u002Fm2 (persisted for at least six months before screening)\n* Stable on their therapy (if any) for ≥ 3 months\n* Free of acute disorders and severe chronic diseases\n* Informed consent signed\n* Normal fasting breath hydrogen levels \\\u003C 15 ppm\n\nExclusion Criteria:\n\n* History of dietary supplement use 4 weeks before the study commences\n* Abnormal values for lab clinical chemistry not related with stiyd outcomes (\\> 2 SD)\n* No consent to randomization\n* Unwillingness to return for follow-up analysis\n* Participation in other clinical trials\n* Participants starting or changing major treatments during the study period",true,"ALL","18 Years",{"count":67,"type":68},120,"ESTIMATED","INTERVENTIONAL",[71],"NA","The Supersaturated Hydrogen-Rich Water for Outpatients with Persistent Excess Weight (HOPE) study is a Phase III, multicenter, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of daily consumption of supersaturated hydrogen-rich water in adults with persistent excess body weight. The trial investigates whether sustained exposure to molecular hydrogen can favorably influence body composition and key metabolic outcomes compared with a placebo water lacking dissolved hydrogen. By enrolling outpatients across multiple centers and applying rigorous blinding and randomization procedures, HOPE aims to generate high-quality clinical evidence on the potential role of hydrogen-rich water as a non-pharmacological, adjunctive strategy for weight management and metabolic health.",[74],"Overweight",[76,77],"Metabolism","Hydrogen","NOT_YET_RECRUITING","2026-02-07",{"date":81,"type":82},"2026-02-13","ACTUAL",{"date":84,"type":68},"2026-04-15",{"date":86,"type":68},"2027-02-15",{"name":5,"class":6},1]