[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612258":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":28,"locations":34,"responsibleParty":53,"collaborators":25,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":25,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":25,"enrollmentInfo":65,"targetDuration":25,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":37,"whyStopped":25,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"University of Valencia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1: Exercise + nutritional supplement (EXNS)","EXPERIMENTAL","Participants in this group will receive an oral daily dose of the natural-origin nutritional supplement in combination with a supervised multicomponent functional exercise program (2 sessions per week, 45-60 minutes each) for 6 months.",[13],"Dietary Supplement: Group 1: Exercise + nutritional supplement (EXNS)",{"label":15,"type":16,"description":17,"interventionNames":18},"Group 2: Exercise + placebo nutritional supplement (EXPlaNS)","PLACEBO_COMPARATOR","Participants in this group will receive a placebo supplement identical in appearance to the active supplement, together with the same multicomponent functional exercise program for 6 months.",[19],"Dietary Supplement: Group 2: Exercise + placebo nutritional supplement (EXPlaNS)",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Participants in this group will receive an oral daily dose of the natural-origin nutritional supplement in combination with a supervised moderate-intensity multicomponent and functional exercise program (2 sessions per week, 45-60 minutes each) for 6 months, composed by three exercise blocks: 1) joint mobility and postural control exercises block, 2) explosive functional strength block with three sets of two strength exercises using elastic bands at 70% of 1RM and performed at maximum speed and, 3) coordination and agility exercises block.",[9],null,{"type":22,"name":15,"description":17,"armGroupLabels":27,"otherNames":25},[15],[29],{"name":30,"role":31,"phone":32,"phoneExt":25,"email":33},"Juan Carlos Colado Sánchez, Chair full professor","CONTACT","(9639) 83470","juan.colado@uv.es",[35],{"facility":36,"status":37,"city":38,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Physical activity and Sport Science Faculty, Valencia, Valencia","RECRUITING","Valencia","46010","Spain","ES",{"type":43,"coordinates":44},"Point",[45,46],-0.37966,39.47391,{"lat":46,"lon":45},[49,50],{"name":30,"role":31,"phone":25,"phoneExt":25,"email":33},{"name":51,"role":52,"phone":25,"phoneExt":25,"email":25},"Juan Carlos Colado Sánchez, Chair full profesor","PRINCIPAL_INVESTIGATOR",{"type":52,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Juan C. Colado","Professor of Physical Education","100612258","supplement-and-exercise-effects-on-stationary-immunity-and-health-in-older-adults-100612258",false,"NCT07251244","Supplement and Exercise Effects on Stationary Immunity and Health in Older Adults","Effects of a Nutritional Supplement and Functional Exercise Program on Seasonal Immunity, Perceived Health, and Oxidative Stress in Older Adults","Inclusion Criteria:\n\n* Adults aged 65 years or older\n* Functional independence, defined as the ability to perform activities of daily living without assistance\n* Sufficient cognitive capacity to understand instructions and complete questionnaires, assessed through interview or brief cognitive screening if necessary\n* Not immunosuppressed\n* Not regular users of antioxidant or immunomodulatory supplements\n* Ability and availability to attend exercise sessions and scheduled assessments throughout the six-month study period\n* Commitment to maintain stable dietary and physical activity habits during the intervention\n\nExclusion Criteria:\n\n* Active autoimmune diseases or clinically relevant immunosuppression\n* Use of corticosteroids or immunosuppressive drugs in the 4 weeks prior to study initiation\n* Active infection or compatible symptoms (fever, cough, diarrhea) in the 2 weeks prior to any measurement\n* Unstable cardiovascular conditions or medical contraindications for moderate physical exercise\n* Moderate to severe cognitive impairment that prevents proper participation in the scheduled activities\n* Participation in another clinical trial in the last 3 months\n* Known allergy or hypersensitivity to the supplement or any of its excipients","ALL","65 Years",{"count":66,"type":67},60,"ESTIMATED","INTERVENTIONAL",[70],"NA","The goal of this clinical trial is to learn whether a natural-origin nutritional supplement, combined with a moderate-intensity functional exercise program, can improve seasonal immunity, perceived health, and oxidative stress in older adults. The study will also assess the safety of this combined intervention.\n\nThe main questions it aims to answer are:\n\n* Does the combination of supplementation and exercise enhance immune function during seasonal changes?\n* Does it reduce oxidative stress and improve perceived health and functional capacity?\n\nResearchers will compare a supplement to a placebo. All participants will follow the same supervised functional exercise program.\n\nParticipants will:\n\n* Take a daily nutritional supplement for 6 months.\n* Attend two weekly functional exercise sessions (60 minutes each), including mobility, explosive strength, and coordination\u002Fagility training.\n* Complete three assessments (before, midway, and after the intervention) including blood tests, physical function evaluations, and quality of life questionnaires.",[73,74],"Aging","Older Adults",[76,77,78,79,80,81,82,83,84,85],"Older adults","Nutritional supplement","Functional exercise","Seasonal immunity","Oxidative stress","Multicomponent training","Healthy aging","Quality of life","Non-pharmacological intervention","Randomized controlled trial","2025-12-15",{"date":88,"type":89},"2025-12-22","ACTUAL",{"date":86,"type":89},{"date":92,"type":67},"2026-07",{"name":5,"class":6},1]