[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100422202":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":27,"locations":33,"responsibleParty":51,"collaborators":56,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":10,"eligibilityCriteria":63,"healthyVolunteers":60,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":10,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":10,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Daping Hospital and the Research Institute of Surgery of the Third Military Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"one dose of surfactant",null,"the preterm infants diagnosed with NRDS and\u002For NARDS will be administrated with only one dose of surfactant",[13],"Drug: one dose of surfactant replacement",{"label":15,"type":10,"description":16,"interventionNames":17},"two and more doses of surfactant","the preterm infants diagnosed with NRDS and\u002For NARDS will be administrated with two and more doses of surfactant",[18],"Drug: two and more doses of surfactant replacement",[20,24],{"type":21,"name":22,"description":11,"armGroupLabels":23,"otherNames":10},"DRUG","one dose of surfactant replacement",[9],{"type":21,"name":25,"description":16,"armGroupLabels":26,"otherNames":10},"two and more doses of surfactant replacement",[15],[28],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"Chen Long, MD, PhD","CONTACT","+8613883559467","neuroclong@126.com",[34],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Chen","RECRUITING","Chongqing","Chongqing Municipality","400042","China","CN",{"type":43,"coordinates":44},"Point",[45,46],106.55771,29.56026,{"lat":46,"lon":45},[49],{"name":50,"role":30,"phone":31,"phoneExt":10,"email":32},"Chen Long, MD,PhD",{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":55,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Chen Long,MD","director","Children's Hospital of Chongqing Medical University",[57],{"name":55,"class":6},"100422202","surfactant-for-neonatal-respiratory-distress-syndromenrds-and-neonatal-acute-respiratory-distress-syndromenards-100422202",false,"NCT04777760","Surfactant for Neonatal Respiratory Distress Syndrome(NRDS) and Neonatal Acute Respiratory Distress Syndrome(NARDS)","Inclusion Criteria:\n\nEligibility requirements for neonates were as follows:\n\n* The gestational age is less than 37 weeks and admitted to neonatal intensive care unit(NICU) in 24 h after birth\n* The neonates will be diagnosed with NRDS or NARDS\n* The neonates will be at least administrated one dose of surfactant\n\nExclusion Criteria:\n\none of the following criteria will be needed\n\n* major congenital anomalies\n* chromosomal abnormalities\n* upper respiratory tract abnormalities","ALL","1 Minute","24 Hours",{"count":68,"type":69},400,"ESTIMATED","OBSERVATIONAL","In preterm infants with neonatal respiratory distress syndrome (NRDS), exogenous pulmonary surfactant(PS) replacement therapy is one of the most important therapeutic breakthrough to reduce neonatal mortality. Nowadays, PS is commonly used in newborn infants with respiratory distress, but the incidences of bronchopulmonary dysplasia(BPD) and\u002For death are inconsistent. The result indicates that not all preterm infants with respiratory distress can be beneficial from PS.\n\nIn 2017, the international neonatal ARDS (NARDS) collaborative group provides the first consensus definition for NARDS. And whether or not PS being beneficial for preterm infants with NARDS remains unknown.",[73,74,75,76],"Respiratory Distress Syndrome","Preterm Birth","Acute Respiratory Distress Syndrome","Surfactant Dysfunction","2025-06-26",{"date":79,"type":80},"2025-07-01","ACTUAL",{"date":82,"type":80},"2021-01-01",{"date":84,"type":69},"2026-12-31",{"name":5,"class":6},1]