[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639325":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":23,"locations":29,"responsibleParty":46,"collaborators":22,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":22,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":22,"enrollmentInfo":59,"targetDuration":22,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":70,"overallStatus":32,"whyStopped":22,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Cairo University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"MINST Group","EXPERIMENTAL","Participants diagnosed with periodontitis will receive minimally invasive non-surgical periodontal therapy (MINST). Clinical periodontal parameters and gingival crevicular fluid samples will be collected at baseline and 6 months after treatment to assess changes in SP-D levels and periodontal outcomes.",[13],"Procedure: Minimally Invasive Non-Surgical Periodontal Therapy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Minimally Invasive Non-Surgical Periodontal Therapy","Minimally invasive non-surgical periodontal therapy will include oral hygiene instructions, supragingival plaque control, and subgingival instrumentation using fine periodontal instruments, miniature Gracey curettes, thin ultrasonic tips, magnification when available, and local anesthesia when needed. Debridement will be performed for periodontal pockets while minimizing trauma to the soft tissues.",[9],[21],"MINST",null,[24],{"name":25,"role":26,"phone":27,"phoneExt":22,"email":28},"Hossam Ashraf ElMasry","CONTACT","+201129559757","hossam.eldamarany@dentistry.cu.edu.eg",[30],{"facility":31,"status":32,"city":33,"state":22,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Faculty of Dentistry, Cairo University","RECRUITING","Cairo","12613","Egypt","EG",{"type":38,"coordinates":39},"Point",[40,41],31.24967,30.06263,{"lat":41,"lon":40},[44],{"name":31,"role":26,"phone":45,"phoneExt":22,"email":22},"01002159535",{"type":47,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"PRINCIPAL_INVESTIGATOR","Hossam Ashraf Elmasry","Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University","100639325","surfactant-protein-d-levels-in-gcf-before-and-after-minst-in-periodontitis-100639325",false,"NCT07599657","Surfactant Protein D Levels in GCF Before and After MINST in Periodontitis","Evaluation of Surfactant Protein D (SP-D) Levels in the GCF of Periodontitis Patients Associated With the Endpoints After Minimally Invasive Non-surgical Periodontal Therapy: A Before and After Study","Inclusion Criteria:\n\n* Male and female participants aged 18 years or older.\n* Diagnosis of periodontitis, classified as stage II or stage III according to the 2018 classification system.\n* Presence of at least one tooth with probing pocket depth (PPD) of 5 mm or more, clinical attachment loss (CAL), and radiographic evidence of bone loss.\n* Presence of at least one intrabony defect with a radiographic intrabony component measuring 3 mm or more.\n\nExclusion Criteria:\n\n* Current smokers or individuals with a history of smoking within the past year.\n* Pregnant or lactating women.\n* Use of systemic antibiotics or anti-inflammatory medications within the last 3 months.\n* Known allergy to any materials or agents used during periodontal therapy.","ALL","18 Years",{"count":60,"type":61},18,"ESTIMATED","INTERVENTIONAL",[64],"NA","This study will evaluate changes in Surfactant Protein D (SP-D) levels in gingival crevicular fluid (GCF) of patients with periodontitis before and after minimally invasive non-surgical periodontal therapy (MINST).\n\nParticipants diagnosed with stage II or III periodontitis will receive minimally invasive non-surgical periodontal treatment. GCF samples will be collected at baseline and 6 months after treatment, and SP-D levels will be measured using enzyme-linked immunosorbent assay (ELISA).\n\nThe study will also assess clinical periodontal outcomes, including full-mouth plaque score, full-mouth bleeding score, probing pocket depth, clinical attachment level, gingival recession, and patient satisfaction. Each participant will serve as their own control by comparing baseline values with 6-month post-treatment values.",[67,68,69],"Periodontitis","Periodontitis Stage II","Periodontitis Stage III",[71,72,73,74,75,21,17,67,76,77],"Surfactant Protein D","Gingival Crevicular Fluid","ELISA","Periodontal Biomarker","Non-Surgical Periodontal Therapy","GCF","SP-D","2026-05-14",{"date":80,"type":81},"2026-05-20","ACTUAL",{"date":78,"type":61},{"date":84,"type":61},"2027-02-01",{"name":5,"class":6},1]