[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622535":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":21,"centralContacts":21,"locations":22,"responsibleParty":40,"collaborators":42,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":21,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":68,"whyStopped":21,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"King's College Hospital NHS Trust","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Surgical resection followed by LITT","Combined unilateral open surgery for maximal tumour resection followed by contralateral LITT to the smaller component\u002Fresidual.",[12],"Procedure: surgery (any volume) and \u002F or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"PROCEDURE","surgery (any volume) and \u002F or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines","All patients will have combined unilateral open surgery for maximal tumour resection followed by contralateral LITT to the smaller component\u002Fresidual.",[9],[20],"laser interstitial thermal therapy",null,[23],{"facility":24,"status":21,"city":25,"state":21,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"King's College NHS Foundation Trust","London","SE5 9RS","United Kingdom","UK",{"type":30,"coordinates":31},"Point",[32,33],-0.12574,51.50853,{"lat":33,"lon":32},[36],{"name":37,"role":38,"phone":39,"phoneExt":21,"email":21},"Keyoumars Ashkan","CONTACT","02032999000",{"type":41,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR",[43],{"name":44,"class":45},"Medtronic","INDUSTRY","100622535","surgery-and-laser-interstitial-thermal-therapy-for-bilateral-glioblastomas-100622535",false,"NCT07384884","Surgery and Laser Interstitial Thermal Therapy for Bilateral Glioblastomas","SLITT-GBM","Inclusion Criteria:\n\n1. Presumptive diagnosis of bGBM as per preoperative MRI and MDT assessment\n2. Presumed residual \u002F smaller component of the bGBM has to be \\\u003C 2.5cm\n3. Performance Status 0-1\n4. Able to consent for the study\n\nExclusion Criteria:\n\n1. bGBM measuring \\>2.5 cm in both hemispheres.\n2. Tumour progression between surgical debulking and LITT treatment\n3. Severe complications after surgery (hydrocephalus, infection, heamatoma, stroke)","ALL","18 Years","80 Years",{"count":57,"type":58},12,"ESTIMATED","INTERVENTIONAL",[61],"NA","Butterfly glioblastomas (bGBM), defined as tumours crossing the midline to involve hemispheres bilaterally, have a dismal prognosis with a median survival of 3.3-6 months and only 9% of patients with bGBM survive 2-years. These figures put bGBM in the worst end of the spectrum of GBM prognosis, significantly inferior to the survival figures quoted in the literature with standard of care - 14.6 months - particularly when 5-aminolevulinic acid is used as surgical adjuvant - 17.47 months.\n\nDespite the poor outcome of this disease, there is preliminary evidence suggesting that active oncology treatment can impact the survival of patients with this condition.With particular regards to surgical resection versus biopsy, there is a suggestion that resection improves overall survival at 6 months with no clear difference at 12 and 18 months of follow up.\n\nLaser-induced thermal therapy (LITT) is a minimally invasive laser ablation technique used in a range of brain tumours, including glioblastomas, with similar overall survival to the ones reported for open surgery in patients with lesions not amenable to open resection. The minimally invasive nature of this technique, significantly reducing the collateral damage to the surrounding brain structures, suggests Its potential in the treatment of this bGBM \\[14\\] with significant implications as a deficit-sparing technique, particularly if associated with preoperative and intraoperative monitoring and mapping techniques.\n\nThe SLITT-GBM study will combine unilateral open surgery for maximal tumour resection with contralateral LITT to the smaller component\u002Fresidual.",[64,65],"Brain Tumours","GBM",[67],"brain tumour","NOT_YET_RECRUITING","2026-02-17",{"date":71,"type":72},"2026-02-19","ACTUAL",{"date":74,"type":58},"2026-03-01",{"date":76,"type":58},"2027-07-01",{"name":5,"class":6},1]