[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100568198":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":21,"responsibleParty":37,"collaborators":10,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":10,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":49,"minAge":50,"maxAge":10,"enrollmentInfo":51,"targetDuration":10,"studyType":54,"phases":10,"briefSummary":55,"conditions":56,"keywords":10,"overallStatus":23,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},{"fullName":5,"class":6},"Vanderbilt University Medical Center","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Healthy community dwelling adults",null,"Healthy adults ≥ 60 years old with no prior history of neurological or respiratory diseases, swallowing impairments, or history of head and neck surgery, cancer, or radiation to the head or neck will be enrolled in this study.",{"label":13,"type":10,"description":14,"interventionNames":10},"Adults with Alzheimer's Disease and their caregivers","Adults with a diagnosis of Alzheimer's disease and their caregivers will be enrolled in this study.",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Cara Donohue, PhD CCC-SLP","CONTACT","615-852-5085","cara.donohue@vumc.org",[22],{"facility":5,"status":23,"city":24,"state":25,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"RECRUITING","Nashville","Tennessee","37232","United States","US",{"type":30,"coordinates":31},"Point",[32,33],-86.78444,36.16589,{"lat":33,"lon":32},[36],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Cara Donohue, Ph.D. CCC-SLP","Assistant Professor, Director of Medical Speech-Language Pathology","100568198","swallowing-impairments-in-adults-with-and-without-alzheimers-disease-100568198",false,"NCT06678100","Swallowing Impairments in Adults With and Without Alzheimer's Disease","Prevalence and Care Partner Burden of Individuals With Alzheimer's Disease","Inclusion criteria for AD cohort:\n\n1. adult ≥60 years old\n2. diagnosis of AD by a neurologist (confirmed with imaging, spinal tap, behavioral testing)\n3. no prior history of other neurological diseases (aside from stroke which has resolved with no current symptoms)\n4. no prior history of respiratory diseases\n5. no prior history of head and neck surgery\u002Fhead and neck cancer\u002Fradiation to head and neck region\n6. consuming some form of oral intake\n7. able to follow basic directions\n8. able\u002Fwilling to provide consent\u002Fassent.\n\nExclusion Criteria for AD Cohort:\n\n1. individual \\\u003C60 years old\n2. Diagnosis of another type of dementia\n3. History of neurological\u002Frespiratory diseases\n4. History of head and neck surgery\u002Fhead and neck cancer\u002Fradiation to head and neck region\n5. not consuming any oral intake\n6. Unable to follow basic directions\n7. Unable to provide consent based on the University of California, San Diego Brief Assessment of Capacity to Consent (UBACC), score \\\u003C15 OR provide assent and a legal guardian\u002Fhealth care decision maker provides consent.\n\nInclusion criteria for care partners of individuals with AD will be:\n\n1. care partner of an individual with AD\n2. willing to complete questionnaires\u002Fparticipate in an interview.\n\nExclusion Criteria for Caregivers of Individuals with AD:\n\n1. not the primary caregiver of an individual with AD\n2. unwilling to complete questionnaires\u002Fsemi-structured interview\n\nInclusion criteria for community-dwelling adults will be:\n\n1. adult ≥60 years old\n2. no prior history of neurological diseases (aside from stroke which has resolved with no current symptoms)\n3. no prior history of respiratory diseases\n\n3\\) no prior history of head and neck surgery\u002Fhead and neck cancer\u002Fradiation to head and neck region 4) no prior history of swallowing difficulties based on participant report. 5) Score ≥25th percentile based on sex\u002Fage\u002Feducation\u002Frace on the Montreal Cognitive Assessment (MOCA)\n\nExclusion Criteria for Healthy Cohort:\n\n1. individual \\\u003C60 years old\n2. history of neurological disease\n3. history of respiratory disease\n4. history of head and neck surgery\u002Fhead and neck cancer\u002Fradiation to head and neck region\n5. history of swallowing difficulties\n6. Score \\\u003C25th percentile based on sex\u002Fage\u002Feducation\u002Frace on the Montreal Cognitive Assessment (MOCA)",true,"ALL","60 Years",{"count":52,"type":53},240,"ESTIMATED","OBSERVATIONAL","This research study is investigating whether people with Alzheimer's disease (AD) experience more changes to swallowing than their healthy age-matched peers. The prevalence of swallowing impairments in moderate-severe AD is high (85-93%), yet little is known about how swallow function evolves throughout the disease course in people with AD. The overall objective of this study is to evaluate swallowing function in adults with and without Alzheimer's disease. The investigator will also be involving the primary caregivers of individuals with Alzheimer's that are enrolled in the study to better understand the impact of swallowing impairments on the primary caregivers of those with Alzheimer's Disease.\n\nHealthy adults and individuals with Alzheimer's disease will:\n\n* undergo tests of cough and swallow function\n* undergo tests of grip and tongue strength\n* complete questionnaires\n\nCaregivers of individuals with Alzheimer's disease will also complete questionnaires.",[57,58,59,60],"Alzheimer Disease","Caregiver Burden","Healthy Aging","Dysphagia","2026-05-06",{"date":63,"type":64},"2026-05-08","ACTUAL",{"date":66,"type":64},"2025-04-21",{"date":68,"type":53},"2028-02",{"name":5,"class":6},1]