[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620729":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":23,"locations":28,"responsibleParty":49,"collaborators":53,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":23,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":23,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":31,"whyStopped":23,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Wageningen University","OTHER",[8,14],{"label":9,"type":6,"description":10,"interventionNames":11},"NNS \u002F no-NNS","In this arm, participants will first receive the NNS diet, and the no-NNS diet in the second study period.",[12,13],"Other: Diet with non-nutritive sweeteners","Other: Diet without non-nutritive sweeteners",{"label":15,"type":6,"description":16,"interventionNames":17},"No-NNS \u002F NNS","In this arm, participants will first receive the no-NNS diet, and the NNS diet in the second study period.",[12,13],[19,24],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"Diet with non-nutritive sweeteners","Fully controlled diet with added mixture of non-nutritive sweeteners. The mixture consist of 6 different non-nutritive sweeteners: acesulfame-K, aspartame, cyclamate, saccharin, sucralose, and rebaudioside A (stevia).",[9,15],null,{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":23},"Diet without non-nutritive sweeteners","Fully controlled diet without any non-nutritive sweeteners added.",[9,15],[29],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Wageningen University & Research","RECRUITING","Wageningen","Gelderland","6708WG","Netherlands","NL",{"type":38,"coordinates":39},"Point",[40,41],5.66667,51.97,{"lat":41,"lon":40},[44],{"name":45,"role":46,"phone":47,"phoneExt":23,"email":48},"Diederik Esser, Dr.","CONTACT","+31317480084","sweetspot@wur.nl",{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Monica Mars","Principal Investigator",[54,57,60,62,64,66,68],{"name":55,"class":56},"Food & Biobased Research - Wageningen UR","UNKNOWN",{"name":58,"class":59},"TKI Agri & Food","INDUSTRY",{"name":61,"class":56},"The Magnum Ice Cream Company",{"name":63,"class":59},"Tate & Lyle",{"name":65,"class":56},"Symrise AG",{"name":67,"class":6},"American Beverage Association",{"name":69,"class":56},"Yildiz Holding","100620729","sweetspot---the-effect-of-non-nutritive-sweeteners-on-health-100620729",false,"NCT07361406","SweetSpot - The Effect of Non-nutritive Sweeteners on Health","SweetSpot - The Effect of Non-nutritive Sweeteners on Glucose Regulation, Gut Microbiome, and Gut Hormone Secretion in Healthy Adults: a Fully Controlled Cross-over Intervention Study","Inclusion Criteria:\n\n* Age 45-79 years;\n* BMI of 20-35 kg\u002Fm2;\n* Having veins suitable for placement of a venflon catheter.\n\nExclusion Criteria:\n\n* Diseases or prior surgeries affecting the stomach, liver, kidneys or intestines (allowed i.e. appendectomy);\n* Cardiovascular diseases (e.g. heart failure) or cancer (e.g. non-invasive skin cancer allowed);\n* Diagnosed with type 1 or type 2 diabetes;\n* Drug treated thyroid diseases (well substituted hypothyroidism is allowed for inclusion);\n* HbA1c level \\>6.5% (\\>48 mmol\u002Fmol), as measured during the screening visit;\n* Anaemia defined as Hb concentrations \\\u003C8.5 mmol\u002FL for men and \\\u003C7.5 mmol\u002FL for women via finger prick;\n* Regular use of\u002Freceiving medication interfering with research outcomes (as judged by research physician), such as use of glucose lowering drugs, insulin, or use of medication that impacts the gastro-intestinal system;\n* Use of antibiotics over the last 3 months before study start;\n* Donated blood within 2 months prior to the screening;\n* Food allergies, intolerances (including lactose\u002Fgluten intolerance) for products used in the study design and\u002For dietary restrictions interfering with the study (including special diets and eating disorders);\n* Followed a diet that can interfere with the study outcomes within 1 month prior to the screening (e.g. ketogenic, sugar free, carbohydrate free);\n* Not willing to eat all products in the study diet, including eggs and dairy. Vegetarian is possible;\n* Not willing to consume non-nutritive sweeteners;\n* Not willing to quit the use of supplements that can interfere with the study outcomes (e.g. pre- or probiotics).\n* Intention to change the intensity of exercise during the study period or planning to join a intensive sport event (e.g. marathon or triathlon);\n* Intention to lose or gain weight;\n* Working night shifts regularly;\n* Smoking regularly\n* Use of soft and\u002For hard drugs (cannabis included);\n* Abuse of alcohol (defined as \\>14 glasses (women) or \\>21 glasses (men) of alcoholic beverages per week);\n* Being pregnant or lactating or planning to become pregnant;\n* Inability to understand study information and\u002For communicate with staff;\n* Participation in another study that involves an intervention within two months prior to the intervention;\n* Working or doing a thesis\u002Finternship at the division of Human Nutrition \\& Health, or the Food, Health \\& Consumer Research group of Wageningen Food \\& Biobased Research.",true,"ALL","45 Years","79 Years",{"count":82,"type":83},60,"ESTIMATED","INTERVENTIONAL",[86],"NA","The aim of the study is to investigate the effect of non-nutritive sweeteners on glucose regulation. Secondary objectives are to investigate the effect of NNS on gut microbiome, gut hormone secretion, sweet taste sensitivity and preference, and the excretion of NNS in urine.",[89],"Healthy Adult",[91,92,93,94],"glucose metabolism","gut microbiome","gut hormones","non-nutritive sweeteners","2026-02-24",{"date":97,"type":98},"2026-02-27","ACTUAL",{"date":100,"type":98},"2026-02-23",{"date":102,"type":83},"2026-11-26",{"name":5,"class":6},1]