[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625813":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":35,"responsibleParty":120,"collaborators":122,"id":130,"slug":131,"hasResults":132,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":132,"sex":138,"minAge":139,"maxAge":140,"enrollmentInfo":141,"targetDuration":30,"studyType":144,"phases":145,"briefSummary":147,"conditions":148,"keywords":150,"overallStatus":60,"whyStopped":30,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":162},{"fullName":5,"class":6},"Centre Hospitalier Universitaire Vaudois","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Device assisted high-dose therapy","EXPERIMENTAL","Participants receive a high-dose, high-intensity (HDHI) motor rehabilitation program supported by digital therapeutic devices, delivered across inpatient, outpatient and home-based settings.",[13],"Behavioral: Device assisted high-dose therapy",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"BEHAVIORAL","Participants undergo a high-dose, high-intensity (HDHI) neurorehabilitation program using CE-marked digital therapeutic devices (MindMotion GO, Izar). The intervention is tailored to individual motor rehabilitation needs and delivered across settings: during inpatient rehabilitation (4-6 weeks) and\u002For home-based outpatient care (8-12 weeks). Participants are expected to train actively for approximately one hour per day (5day week), supported by clinical staff and if applicable, caregivers.The intervention is supervised by clinical teams specifically trained in the HDHI protocol, who provide ongoing therapeutic support and monitor progress across settings.",[9],[20],"Device assisted high-dose neurorehabilitation",[22],{"name":23,"affiliation":5,"role":24},"Andrea Serino, Prof.","STUDY_CHAIR",[26,32],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},"Olivier Bill, MD","CONTACT","+41 0213141260",null,"olivier.bill@chuv.ch",{"name":23,"role":28,"phone":33,"phoneExt":30,"email":34},"+41 21 314 3996","andrea.serino@chuv.ch",[36,58,75,89,104],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Lake Lucerne Institute","NOT_YET_RECRUITING","Vitznau","Canton of Lucerne","6354","Switzerland","CH",{"type":45,"coordinates":46},"Point",[47,48],8.4842,47.01014,{"lat":48,"lon":47},[51,55],{"name":52,"role":28,"phone":53,"phoneExt":30,"email":54},"Christoph Bauer, PhD.","+41 79 527 24 49","christoph.bauer@llui.org",{"name":56,"role":57,"phone":30,"phoneExt":30,"email":30},"Christoph Bauer, PhD","PRINCIPAL_INVESTIGATOR",{"facility":59,"status":60,"city":61,"state":62,"zip":63,"country":42,"countryCode":43,"cosmosGeoPoint":64,"geoPoint":68,"contacts":69},"Klinik Valens","RECRUITING","Valens","Canton of St. Gallen","7317",{"type":45,"coordinates":65},[66,67],9.47705,46.96658,{"lat":67,"lon":66},[70,74],{"name":71,"role":28,"phone":72,"phoneExt":30,"email":73},"Jens Bansi, Dr.","+41 585101302","jens.bansi@kliniken-valens.ch",{"name":71,"role":57,"phone":30,"phoneExt":30,"email":30},{"facility":76,"status":60,"city":77,"state":78,"zip":79,"country":42,"countryCode":43,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"Centre hospitalier universitaire Vaudois","Lausanne","Canton of Vaud","1011",{"type":45,"coordinates":81},[82,83],6.63282,46.516,{"lat":83,"lon":82},[86,88],{"name":87,"role":28,"phone":29,"phoneExt":30,"email":31},"Olivier Bill",{"name":27,"role":57,"phone":30,"phoneExt":30,"email":30},{"facility":90,"status":60,"city":91,"state":78,"zip":92,"country":42,"countryCode":43,"cosmosGeoPoint":93,"geoPoint":97,"contacts":98},"Swiss Réhabilitation Sàrl","Sullens","1036",{"type":45,"coordinates":94},[95,96],6.56687,46.59557,{"lat":96,"lon":95},[99,103],{"name":100,"role":28,"phone":101,"phoneExt":30,"email":102},"Nicolas Perret","+41 021 866 66 75","nicolas.perret@hesav.ch",{"name":100,"role":57,"phone":30,"phoneExt":30,"email":30},{"facility":105,"status":38,"city":106,"state":107,"zip":108,"country":42,"countryCode":43,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"Universitätspital Zürich","Zurich","Canton of Zurich","8006",{"type":45,"coordinates":110},[111,112],8.55,47.36667,{"lat":112,"lon":111},[115,119],{"name":116,"role":28,"phone":117,"phoneExt":30,"email":118},"Andreas Luft, Prof.","+41 0798626436","andreas.luft@usz.ch",{"name":116,"role":57,"phone":30,"phoneExt":30,"email":30},{"type":57,"investigatorFullName":87,"investigatorTitle":121,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"MD",[123,126,128],{"name":124,"class":125},"Mindmaze SA","INDUSTRY",{"name":127,"class":6},"Innosuisse - Swiss Innovation Agency",{"name":129,"class":125},"Cereneo AG","100625813","swissneurorehab---hdhi-100625813",false,"NCT07427511","SwissNeuroRehab - HDHI","SwissNeuroRehab - High Dose High Intensity Neurorehabilitation Along the Continuum of Care","SNR-HDHI","Inclusion Criteria:\n\n* Adults aged 18-85 years.\n* Confirmed diagnosis of stroke (ischemic or hemorrhagic) \\>7 days ago\n* Be able to sit unassisted\n* Able and willing to give informed consent\n* Have motor difficulties of the Upper Extremity and\u002For Lower Extremity\n* Willing to commit to program length \\& daily training dose\n* Willing to have assessments at start and end of program\n* Signed informed consent\n\nExclusion Criteria:\n\n* Severe cognitive impairment\n* Uncontrolled seizure disorder or epilepsy - clinician's judgement)\n* Any medical condition that would compromise their safety (inability to communicate, vision or hearing impairment, heart condition that limits participation in exercise) and tolerability (cardiac contraindications)\n* Pain that would limit rehabilitation dose\n* Severe apraxia\n* Severe memory disorder\n* Severe hemispatial neglect\n* Plegia of the affected limb","ALL","18 Years","85 Years",{"count":142,"type":143},120,"ESTIMATED","INTERVENTIONAL",[146],"NA","High-dose, high-intensity (HDHI) neurorehabilitation has shown promise for improving functional outcomes after acquired brain injury (ABI), yet its feasibility and impact across different stages of care and real-world clinical settings remain insufficiently understood.\n\nThe SwissNeuroRehab (SNR) initiative, bringing together Swiss rehabilitation centres to develop and evaluate innovative, technology-supported models of neurorehabilitation, provides the broader framework within which this study is conducted.\n\nWithin this framework, a structured HDHI therapy pathway supported by CE-marked digital neurorehabilitation tools has been developed for delivery across inpatient, outpatient, and home environments in Switzerland.\n\nThis multicentre, non-randomised interventional feasibility study evaluates the feasibility and preliminary clinical effects of implementing this HDHI rehabilitation pathway for adults with stroke in subacute and chronic stages. Participants will receive approximately 300 minutes per week of active, technology-supported training in addition to standard rehabilitation care, following an individually tailored pathway across settings. Standardised clinical assessments, patient-reported outcomes, documentation of rehabilitation procedures, and socioeconomic measures will be collected at baseline, discharge, and follow-up timepoints up to 12-15 months post-enrollment.\n\nThe primary aim of the study is to assess the feasibility of the HDHI intervention within routine rehabilitation workflows across multiple Swiss centres. Feasibility will be evaluated through (i) adherence to at least half of the weekly 300-minute Active Training Time target and (ii) patients' perceived feasibility and satisfaction with the program.\n\nSecondary aims are to explore preliminary clinical and functional changes, patient-reported outcomes, and quantify socioeconomic impacts through dedicated surveys and cost data.\n\nFindings from this study will (i) determine whether a structured HDHI rehabilitation pathway can be feasibly implemented across diverse clinical contexts, (ii) provide initial estimates of clinical and socioeconomic outcomes to support planning of future controlled trials.",[149],"Stroke",[151,152],"high dose","intensive therapy","2026-03-06",{"date":155,"type":156},"2026-03-10","ACTUAL",{"date":158,"type":143},"2026-02-10",{"date":160,"type":143},"2028-05-31",{"name":5,"class":6},5]