[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544806":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":44,"responsibleParty":62,"collaborators":64,"id":68,"slug":25,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":25,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":25,"enrollmentInfo":77,"targetDuration":25,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":25,"overallStatus":47,"whyStopped":25,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Medical University of South Carolina","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Choice of Medication","EXPERIMENTAL","This arm includes participants randomly assigned to the Meds Group. Participants will choose between 1) combo NRT and 2) varenicline. The NRT will consist of transdermal NRT and nicotine lozenge. Participants will receive study product for 11 weeks.",[13],"Behavioral: Switching using Medication",{"label":15,"type":10,"description":16,"interventionNames":17},"Choice of E-Cigarette","This arm includes participants randomly assigned to the E-Cigarette Group. Participants will choose between two different brands of e-cigarettes and choose up to two different flavors. Participants will receive study product for 11 weeks.",[18],"Behavioral: Switching to E-Cigarette",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Switching to E-Cigarette","Participants will receive eleven weeks of e-cigarette products with instructions to switch completely at switch date",[15],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Switching using Medication","Participants will receive eleven weeks of FDA approved medication, either varenicline or combination NRT, with instructions to quit smoking cigarettes at quit date",[9],[31],{"name":32,"affiliation":33,"role":34},"Tracy Smith","smithtra@musc.edu","PRINCIPAL_INVESTIGATOR",[36,40],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":33},"Tracy Smith, PhD","CONTACT","(843)-792-5164",{"name":41,"role":38,"phone":42,"phoneExt":25,"email":43},"Merritt McDonald","(843)-876-2430","mcdoname@musc.edu",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Medical Univeristy of South Carolina","RECRUITING","Charleston","South Carolina","29425","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-79.93275,32.77632,{"lat":57,"lon":56},[60],{"name":37,"role":38,"phone":61,"phoneExt":25,"email":33},"843-792-5164",{"type":34,"investigatorFullName":32,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Associate Professor-Faculty",[65],{"name":66,"class":67},"National Institute on Drug Abuse (NIDA)","NIH","100544806",false,"NCT06373679","Switch or Quit R01","Non-cigarette Tobacco Products as Harm Reduction Tools in Smokers Who Failed to Quit With Traditional Methods","Inclusion Criteria\n\n* Adults 21+ who previously had a quit attempt using FDA-approved pharmacotherapy.\n* Interest in reducing harms from tobacco use or quitting smoking\n\nExclusion Criteria\n\n* Pregnant, breastfeeding, or trying to become pregnant.\n* Household member currently enrolled in the study\n* Planning to move out of the area within the next 7 months",true,"ALL","21 Years",{"count":78,"type":79},225,"ESTIMATED","INTERVENTIONAL",[82],"NA","This study evaluates whether non-cigarette tobacco products (e-cigarettes) can help smokers quit smoking as compared to traditional quit methods (nicotine replacement therapy or varenicline\u002FChantix). Participants in this study will be randomly assigned to one of two groups, then will have a choice between the offered products of that group. Participants in the e-cigarette group will have a choice of e-cigarette brand and flavor. Participants in the medication group will have choice between nicotine replacement therapy (patches and lozenges) or varenicline, also known as Chantix. Participation will last 6 months and will include weekly phone calls for the initial 7-weeks plus a 11-week phone call and a 6-month follow-up visit. Participants will also complete electronic daily diaries during the first 7-weeks.",[85,86],"Cigarette Smoking","Smoking Behaviors","2025-07-22",{"date":89,"type":90},"2025-07-25","ACTUAL",{"date":92,"type":90},"2024-07-10",{"date":94,"type":79},"2027-05-01",{"name":5,"class":6},1]