[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629236":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":34,"centralContacts":38,"locations":47,"responsibleParty":73,"collaborators":75,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":81,"sex":86,"minAge":87,"maxAge":10,"enrollmentInfo":88,"targetDuration":10,"studyType":91,"phases":10,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":50,"whyStopped":10,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"University of Edinburgh","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Patients with symptomatic peripheral arterial disease",null,[12,13,14,15],"Radiation: Whole body [68Ga]DOTATATE PET-CT","Radiation: Whole body [18F]GP1 PET-CT","Radiation: Whole body [18F]NaF PET-CT","Radiation: Whole body CT angiogram",[17,22,26,30],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"RADIATION","Whole body [68Ga]DOTATATE PET-CT","Targeting vascular inflammation",[9],{"type":18,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"Whole body [18F]GP1 PET-CT","Targeting thrombus activity",[9],{"type":18,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"Whole body [18F]NaF PET-CT","Targeting vascular microcalcification",[9],{"type":18,"name":31,"description":32,"armGroupLabels":33,"otherNames":10},"Whole body CT angiogram","To determine anatomical and morphological atherosclerotic plaque characteristics",[9],[35],{"name":36,"affiliation":5,"role":37},"Rachael O Forsythe, MBChB, PhD, FRCS (Vascular)","PRINCIPAL_INVESTIGATOR",[39,44],{"name":40,"role":41,"phone":42,"phoneExt":10,"email":43},"Allison c Winarski, MBChB, MRCS(Ed)","CONTACT","+447495905258","awinarsk@ed.ac.uk",{"name":36,"role":41,"phone":45,"phoneExt":10,"email":46},"+44 01312423585","rachael.forsythe@ed.ac.uk",[48],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Royal Infirmary of Edinburgh","RECRUITING","Edinburgh","Midlothian","EH16 4SA","United Kingdom","UK",{"type":57,"coordinates":58},"Point",[59,60],-3.19648,55.95206,{"lat":60,"lon":59},[63,65,67,70,71],{"name":64,"role":41,"phone":42,"phoneExt":10,"email":43},"Allison C Winarski, MBChB MRSC(Ed)",{"name":36,"role":41,"phone":66,"phoneExt":10,"email":46},"01312423585",{"name":68,"role":69,"phone":10,"phoneExt":10,"email":10},"Allison C Winarski, MBChB MRCS (Ed)","SUB_INVESTIGATOR",{"name":36,"role":37,"phone":10,"phoneExt":10,"email":10},{"name":72,"role":69,"phone":10,"phoneExt":10,"email":10},"David E Newby, BSc (Hons)PhD BM DM DSc FRCP",{"type":74,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[76],{"name":77,"class":78},"NHS Lothian","OTHER_GOV","100629236","symptomatic-and-systemic-atherosclerotic-plaque-activity-in-patients-with-peripheral-arterial-disease-using-novel-imaging-100629236",false,"NCT07472049","Symptomatic and Systemic Atherosclerotic Plaque Activity in Patients With Peripheral Arterial Disease Using Novel Imaging","SISYPHUS","Inclusion Criteria:\n\n* Male or female aged \\> 18 years\n* Symptomatic atherosclerotic peripheral artery disease;\n\n  * Intermittent claudication; with ankle\u002Farm blood pressure ratio \\\u003C0.90 or artery stenosis \\>50% in addition to at least one of the following;\n\n    * \\>1 vascular bed affected by atherosclerosis\n    * Diabetes\n    * Heart failure\n    * Chronic kidney disease (eGFR \\\u003C 60 mL\u002Fmin\u002F1.73 m2)\n  * Rest pain or necrosis of limb or gangrene of limb\n  * Revascularization defined as limb bypass surgery or endovascular revascularization procedures (irrespective of the specific device used), including percutaneous transluminal angioplasty\u002Fstent of iliac or infra-inguinal arteries or extra-anatomical bypass surgery\n  * Leg or foot amputation for arterial vascular indications\n* Ability to give written or verbal informed consent\n\nExclusion Criteria:\n\n* Contraindication to colchicine or iodinated contrast\n* Long term requirement for colchicine for another clinical indication\n* Active diarrhoea\n* Recent lower limb revascularisation for symptomatic disease (\\\u003C6 weeks)\n* Renal failure (glomerular filtration rate \\\u003C30 mL\u002Fmin\u002F1.73 m2)\n* Cirrhosis or severe chronic liver disease\n* Women who are pregnant or breast-feeding\n* Women of child-bearing potential not protected by reliable contraception or is planning conception during the study\n* Current or planned long term use of cyclosporine, verapamil, HIV protease inhibitors, azole antifungals, or macrolide antibiotics (apart from azithromycin)\n* Patients deemed unlikely to return for follow up\n* Life expectancy \\\u003C1 year\n* Inability or unwilling to give informed consent","ALL","18 Years",{"count":89,"type":90},100,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to characterise the relationships between inflammation, microcalcification and thrombus activity in atherosclerotic plaques in peripheral and systemic vascular territories in patients with symptomatic peripheral arterial disease.",[94,95],"Peripheral Arterial Disease","Chronic Limb Threatening Ischemia",[97,98,99,100,101,102,103],"Peripheral arterial disease","Chronic limb threatening ischaemia","PET-CT","cardiovascular diseases","Sodium Fluoride","GP1","DOTATATE","2026-03-11",{"date":106,"type":107},"2026-03-16","ACTUAL",{"date":109,"type":107},"2025-07-31",{"date":111,"type":90},"2029-07",{"name":5,"class":6},1]