[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626026":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":26,"responsibleParty":31,"collaborators":26,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":39,"eligibilityCriteria":40,"healthyVolunteers":35,"sex":41,"minAge":42,"maxAge":43,"enrollmentInfo":44,"targetDuration":26,"studyType":47,"phases":48,"briefSummary":50,"conditions":51,"keywords":54,"overallStatus":59,"whyStopped":26,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":26},{"fullName":5,"class":6},"Centenario Hospital Miguel Hidalgo","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Synbiotic Group","EXPERIMENTAL","Participants assigned to this arm will receive a daily oral synbiotic supplement for a period of 16 weeks.",[13],"Dietary Supplement: Synbiotic Supplement",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Group","PLACEBO_COMPARATOR","Participants assigned to this arm will receive a placebo identical in appearance and administration to the synbiotic for 16 weeks.",[19],"Other: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Synbiotic Supplement","Oral synbiotic supplement administered once daily for 16 weeks.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","Placebo identical in appearance, taste, and administration to the synbiotic supplement, administered once daily for 16 weeks.",[15],{"type":32,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100626026","synbiotic-supplementation-and-inflammation-in-predialysis-chronic-kidney-disease-100626026",false,"NCT07430280","Synbiotic Supplementation and Inflammation in Predialysis Chronic Kidney Disease","Effect of a Synbiotic Containing Lactobacillus Rhamnosus, Bifidobacterium Longum, and Agave Fructans on High-Sensitivity C-Reactive Protein Levels in Patients With Predialysis Chronic Kidney Disease: A Double-Blind, Placebo-Controlled Trial","SSIPCKD","Inclusion Criteria:\n\n* Adults aged 18 to 80 years.\n* Diagnosis of chronic kidney disease in pre-dialysis stages.\n* Stable clinical condition for at least 3 months prior to enrollment.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Current renal replacement therapy (hemodialysis or peritoneal dialysis).\n* Acute kidney injury.\n* Use of antibiotics, probiotics, prebiotics, or synbiotics within 4 weeks prior to enrollment.\n* Active infection, inflammatory disease, or malignancy.\n* Pregnancy or breastfeeding\n* Known intolerance or allergy to components of the synbiotic or placebo.","ALL","18 Years","80 Years",{"count":45,"type":46},100,"ESTIMATED","INTERVENTIONAL",[49],"NA","Chronic kidney disease (CKD) is a long-term condition in which the kidneys gradually lose their ability to function properly. People with chronic kidney disease (CKD) often experience chronic inflammation and digestive symptoms that may affect their quality of life.\n\nThis study aims to evaluate whether daily supplementation with a synbiotic (a combination of probiotics and prebiotics) can reduce inflammation and improve gastrointestinal symptoms in adults with chronic kidney disease (CKD) stages 3 to 5 who are not receiving dialysis.\n\nParticipants will be randomly assigned to receive either a synbiotic containing Lactobacillus rhamnosus, Bifidobacterium longum, and agave fructans, or a placebo, for a total of 16 weeks. Blood tests will be performed to measure inflammation, and participants will complete questionnaires related to digestive symptoms, quality of life, and dietary habits.\n\nThe information obtained from this study may help improve nutritional strategies and supportive care for people living with chronic kidney disease.",[52,53],"Chronic Kidney Disease","Inflammation",[55,56,57,58],"Synbiotic","Gut microbiota","Predialysis","Nutrition intervention","NOT_YET_RECRUITING","2026-02-24",{"date":62,"type":63},"2026-02-27","ACTUAL",{"date":65,"type":46},"2026-03-01",{"date":67,"type":46},"2026-06-01",{"name":5,"class":6}]