[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603888":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":45,"centralContacts":50,"locations":58,"responsibleParty":71,"collaborators":73,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":41,"eligibilityCriteria":82,"healthyVolunteers":78,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":41,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":98,"whyStopped":41,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Rush University Medical Center","OTHER",[8,15,21],{"label":9,"type":10,"description":11,"interventionNames":12},"Two Synovial Fluid Withdrawals","ACTIVE_COMPARATOR","Subjects randomized to Arm 1 will have 2 synovial fluid withdrawals; one at the preoperative clinic visit and one at the time of surgery",[13,14],"Procedure: Synovial Fluid withdrawal at the preoperative clinic visit","Procedure: Synovial fluid withdrawal at the time of surgery",{"label":16,"type":17,"description":18,"interventionNames":19},"Platelet-Rich Plasma (PRP) and Two Synovial Fluid Withdrawals","EXPERIMENTAL","Subjects randomized to ARM 2 will have 2 synovial fluid withdrawals one at the preoperative visit and one at the time of surgery. Platelet-Rich Plasma (PRP) preparation and injection will happen at the preoperative clinic visit.",[13,20,14],"Procedure: Platelet-Rich Plasma (PRP) preparation and injection",{"label":22,"type":6,"description":23,"interventionNames":24},"3mL Synovial Fluid Withdrawal and Synovial Fluid Withdrawal at the Time of Surgery","Subjects randomized to Arm 3 will have 3mL withdrawal of synovial fluid at the preoperative visit and 1 synovial fluid withdrawal at the time of surgery",[14,25],"Procedure: 3mL synovial fluid withdrawn at the preoperative visit",[27,33,38,42],{"type":28,"name":29,"description":29,"armGroupLabels":30,"otherNames":31},"PROCEDURE","Synovial Fluid withdrawal at the preoperative clinic visit",[16,9],[32],"arthrocentesis",{"type":28,"name":34,"description":34,"armGroupLabels":35,"otherNames":36},"Platelet-Rich Plasma (PRP) preparation and injection",[16],[37],"platelet rich plasma",{"type":28,"name":39,"description":39,"armGroupLabels":40,"otherNames":41},"Synovial fluid withdrawal at the time of surgery",[22,16,9],null,{"type":28,"name":43,"description":43,"armGroupLabels":44,"otherNames":41},"3mL synovial fluid withdrawn at the preoperative visit",[22],[46],{"name":47,"affiliation":48,"role":49},"Adam Yanke, MD, PhD","Associate Professor and Surgeon","PRINCIPAL_INVESTIGATOR",[51,55],{"name":47,"role":52,"phone":53,"phoneExt":41,"email":54},"CONTACT","(312) 432-2818","cartilage.restoration@rushortho.com",{"name":56,"role":52,"phone":41,"phoneExt":41,"email":57},"Jorge Chahla, MD, PhD","jorge.chahla@rushortho.com",[59],{"facility":5,"status":41,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":41},"Chicago","Illinois","60612","United States","US",{"type":66,"coordinates":67},"Point",[68,69],-87.65005,41.85003,{"lat":69,"lon":68},{"type":72,"investigatorFullName":41,"investigatorTitle":41,"investigatorAffiliation":41,"oldNameTitle":41,"oldOrganization":41},"SPONSOR",[74],{"name":75,"class":6},"Arthroscopy Association of North America","100603888","synovial-fluid-withdrawal-or-prp-injection-for-acute-acl-tears-and-cytokines-100603888",false,"NCT07142369","Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines","Does Arthrocentesis and PRP For Acute ACL Tears With Hemarthrosis Decrease Inflammatory Cytokines At Time Of Surgery: A Prospective Randomized Control Trial (RCT)","Inclusion Criteria:\n\n* Age 18 - 50\n* English-speaking\n* Clinical evidence of ACL rupture with swelling\n* Participant must be undergoing ACL reconstruction surgery\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>50\n* Presentation \\>3 weeks after initial injury\n* Previous traumatic ipsilateral (same side) knee injury consistent with chronic ACL tear or prior ACL surgery\n* \\> Kellgren-Lawrence grade 2 changes on preoperative x-ray\n* History of hemophilia or inflammatory arthropathy (e.g., rheumatoid arthritis)","ALL","18 Years","50 Years",{"count":87,"type":88},99,"ESTIMATED","INTERVENTIONAL",[91],"NA","The purpose of this study is to determine what effects the withdrawal of excess knee joint fluid or the injection of a factor from the blood has on swelling after a sudden anterior cruciate ligament (ACL) rupture of the knee.",[94,95],"Posttraumatic Osteoarthritis","Anterior Cruciate Ligament (ACL) Rupture",[97],"osteoarthritis","NOT_YET_RECRUITING","2026-06-17",{"date":101,"type":102},"2026-06-18","ACTUAL",{"date":104,"type":88},"2026-09",{"date":106,"type":88},"2028-12",{"name":5,"class":6},1]