[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558034":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":40,"locations":46,"responsibleParty":62,"collaborators":10,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":10,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":10,"enrollmentInfo":74,"targetDuration":77,"studyType":78,"phases":10,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":87,"whyStopped":10,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"patients who received systemic thrombolysis",null,"patients have been diagnosed with acute intermediate-high pulmonary embolism received I.V. streptokinase if there are no contraindications.",[13],"Drug: Streptokinase Injection",{"label":15,"type":10,"description":16,"interventionNames":17},"patients who underwent catheter-based intervention","patients have been diagnosed with acute intermediate-high pulmonary embolism underwent catheter-based intervention including thrombus aspiration or catheter directed thrombolysis using Penumbra System",[18],"Device: Penumbra System",[20,28],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Streptokinase Injection","250000 IU as a loading dose over 30 min. Followed by 100000 IU\u002Fhour over 12:24hours or accelerated regimen 1.5 million IU over 2 hours",[9],[26,27],"Kabikinase","Streptase",{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":10},"DEVICE","Penumbra System","which comprised of several devices:\n\n* RED Reperfusion Catheters\n* Penumbra JET Reperfusion Catheters\n* ACE Reperfusion Catheters\n* MAX Reperfusion Catheters\n* 3D Revascularization Device\n* Penumbra ENGINE Aspiration Source\n* Penumbra ENGINE Canister\n* Aspiration Tubing",[15],[34,37],{"name":35,"affiliation":5,"role":36},"Ayman K Mohamed, PHD","PRINCIPAL_INVESTIGATOR",{"name":38,"affiliation":5,"role":39},"Mohamed O Abdelhameed, master","STUDY_DIRECTOR",[41],{"name":42,"role":43,"phone":44,"phoneExt":10,"email":45},"mariam J william","CONTACT","01009083119","mariamjoseph1997@gmail.com",[47],{"facility":48,"status":10,"city":49,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Hospital University","Asyut","Egypt","EG",{"type":53,"coordinates":54},"Point",[55,56],31.18368,27.18096,{"lat":56,"lon":55},[59],{"name":38,"role":43,"phone":60,"phoneExt":10,"email":61},"01061878040","mosman87@gmail.com",{"type":36,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Mariam J William","Principal Investigator","100558034","systemic-thrombolysis-versus-catheter-directed-management-for-acute-intermediate-high-pulmonary-embolism-100558034",false,"NCT06545864","Systemic Thrombolysis Versus Catheter Directed Management for Acute Intermediate-high Pulmonary Embolism","In Hospital Clinical Outcomes and Short Term Follow up of Systemic Thrombolysis Versus Catheter Directed Management for the Treatment of Acute Intermediate-high Pulmonary Embolism","Inclusion Criteria:\n\nPatients diagnosed with acute intermediate-high pulmonary embolism\n\nExclusion Criteria:\n\n* Patients less than 18 years of age.\n* Low risk, intermediate low risk, acute pulmonary embolism\n* patients with RV masses will be excluded.\n* Patient refusal of treatment strategy.","ALL","18 Years",{"count":75,"type":76},50,"ESTIMATED","1 Month","OBSERVATIONAL","To compare in hospital clinical outcomes and one month follow up of systemic thrombolysis versus catheter directed management for the treatment of acute intermediate- high risk pulmonary embolism (using streptokinase or tissue plasminogen activator (TPA) and catheter-based intervention group using Penumbra System).",[81],"Acute Pulmonary Embolism",[83,84,85,86],"intermediate-high","acute pulmonary embolism","systemic thrombolysis","catheter- directed management","NOT_YET_RECRUITING","2024-08-07",{"date":90,"type":91},"2024-08-09","ACTUAL",{"date":93,"type":76},"2024-10-01",{"date":95,"type":76},"2030-03-01",{"name":5,"class":6},1]