[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100535217":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":10,"centralContacts":23,"locations":33,"responsibleParty":52,"collaborators":55,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":10,"maxAge":10,"enrollmentInfo":78,"targetDuration":10,"studyType":81,"phases":10,"briefSummary":82,"conditions":83,"keywords":10,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Karolinska Institutet","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with immune dysregulation",null,"Patients sampled before and during different immunomodulatory therapies due to immune system dysregulation.",[13],"Combination Product: Immunomodulation",{"label":15,"type":10,"description":16,"interventionNames":10},"Healthy subjects","Age-matched healthy individuals sampled longitudinally",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"COMBINATION_PRODUCT","Immunomodulation","Variable protocols for combined immunomodulatory therapies currently in use for different forms of immune dysregulation",[9],[24,30],{"name":25,"role":26,"phone":27,"phoneExt":28,"email":29},"Petter Brodin, M.D., Ph.D","CONTACT","08 524 813 96","+46","petter.brodin@ki.se",{"name":31,"role":26,"phone":10,"phoneExt":10,"email":32},"Genia Kretzschmar, M.D","genia.kretzschmar@ki.se",[34],{"facility":5,"status":35,"city":36,"state":10,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"RECRUITING","Stockholm","SE171 77","Sweden","SE",{"type":41,"coordinates":42},"Point",[43,44],18.06871,59.32938,{"lat":44,"lon":43},[47,50],{"name":48,"role":26,"phone":49,"phoneExt":10,"email":29},"Petter Brodin, MD PhD","+46 8 52481396",{"name":48,"role":51,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"type":51,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Petter Brodin","M.D., Ph.D., Professor",[56,58,60,62,64,66],{"name":57,"class":6},"Karolinska University Hospital",{"name":59,"class":6},"Skane University Hospital",{"name":61,"class":6},"Sahlgrenska University Hospital",{"name":63,"class":6},"Uppsala University Hospital",{"name":65,"class":6},"Region Halland",{"name":67,"class":68},"Region Jönköping County","OTHER_GOV","100535217","systems-level-analyses-of-immune-dysregulation-100535217",false,"NCT06248957","SYSTEMS-LEVEL ANALYSES OF IMMUNE DYSREGULATION","SAID","Inclusion Criteria:\n\nPatients of all ages seeking care or being referred for suspected immune dysregulation or with a known immune-mediated disease and failing to respond to standard therapy\n\nExclusion Criteria:\n\nHealthy control individuals will be excluded on the basis of having a diagnosis of an immune mediated disorder, immunomodulatory treatment or current infection or cancer.",true,"ALL",{"count":79,"type":80},500,"ESTIMATED","OBSERVATIONAL","The aim of the SAID study is to create a national resource in Sweden to enable comprehensive immunological analyses of an extremely complex and clinically challenging group of individuals with variable forms of immune system dysregulation. We hope to establish a biobank of primarily blood and fecal samples from children and adults, with confirmed or suspected immune dysregulation, as well as age- and sex- matched healthy controls, for comparisons of immune cell\u002Fmediator alongside various clinical presentations of these immunological diseases as well as microbiome samples as possible a possible modifier of clinical presentations. The project will also include the establishment of a national database with deep immunological data, treatment and clinical outcomes for these patients, accessible to participating researchers and clinicians.",[84,85,86,87,88],"Immunodeficiency","Autoimmune Diseases","Autoinflammatory Syndrome","Allergy","Dysregulated Host Response","2024-01-31",{"date":91,"type":92},"2024-02-08","ACTUAL",{"date":94,"type":92},"2024-01-01",{"date":96,"type":80},"2031-12-31",{"name":5,"class":6},1]