[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100456642":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":19,"centralContacts":20,"locations":29,"responsibleParty":76,"collaborators":19,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":80,"sex":86,"minAge":87,"maxAge":19,"enrollmentInfo":88,"targetDuration":19,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":19,"overallStatus":32,"whyStopped":19,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Centre Hospitalier Universitaire de Nice","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"high-risk of weaning-induced pulmonary edema","Critically-ill patients under mechanical ventilation for more than 48h, who are at high-risk of weaning-induced pulmonary edema and in whom the attending physician decided to perform a spontaneous breathing trial.",[12],"Procedure: Spontaneous breathing trial",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"PROCEDURE","Spontaneous breathing trial","To perform cardiac and lung echography before and during a spontaneous breathing trial",[9],null,[21,26],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Mathieu JOZWIAK, MD, PhD","CONTACT","33492035510","jozwiak.m@chu-nice.fr",{"name":27,"role":23,"phone":24,"phoneExt":19,"email":28},"Jean DELLAMONICA, MD, PhD","dellamonica.j@chu-nice.fr",[30,48,62],{"facility":31,"status":32,"city":33,"state":19,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"CHU de Dijon","RECRUITING","Dijon","21079","France","FR",{"type":38,"coordinates":39},"Point",[40,41],5.01391,47.31344,{"lat":41,"lon":40},[44],{"name":45,"role":23,"phone":46,"phoneExt":19,"email":47},"Bélaïd BOUHEMAD, MD, PhD","33 3 8018 13 09","belaid_bouhemad@hotmail.com",{"facility":49,"status":32,"city":50,"state":19,"zip":51,"country":35,"countryCode":36,"cosmosGeoPoint":52,"geoPoint":56,"contacts":57},"CHU de NICE","Nice","06200",{"type":38,"coordinates":53},[54,55],7.26608,43.70313,{"lat":55,"lon":54},[58,61],{"name":59,"role":23,"phone":60,"phoneExt":19,"email":25},"Mathieu JOZWIAK, Md, PhD","+33492035510",{"name":27,"role":23,"phone":60,"phoneExt":19,"email":28},{"facility":63,"status":32,"city":64,"state":19,"zip":65,"country":35,"countryCode":36,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"Hôpital Cochin","Paris","75014",{"type":38,"coordinates":67},[68,69],2.3488,48.85341,{"lat":69,"lon":68},[72],{"name":73,"role":23,"phone":74,"phoneExt":19,"email":75},"Driss LAGHLAM","33158412517","driss.laghlam@gmail.com",{"type":77,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100456642","systolic-function-and-weaning-induced-pulmonary-edema-systowean-study-100456642",false,"NCT05226247","Systolic Function and Weaning-induced Pulmonary Edema (SystoWean Study)","Evaluation of the Role of Systolic Dysfunction in Weaning Failure Related to Weaning-induced Pulmonary Edema: the SystoWean Study","SystoWean","Inclusion Criteria:\n\n1. Invasive mechanical ventilation for more than 48 hours\n2. Patients indicated, according to intensivists, for carrying out a spontaneous breathing trial weaning test, based on the presence of all of the following criteria:\n\n   1. SpO2\\> 90% with FiO2 ≤40% and PEEP ≤5 cmH2O\n   2. Cough effectiveness on tracheal aspirations\n   3. Lack of hemodynamic instability and of disorders of consciousness\n3. Patients at high risk of weaning-induced pulmonary edema (WIPO), defined by one or more of the following criteria:\n\n   1. Obesity, defined by a body mass index\\> 30 kg\u002Fm²\n   2. Chronic obstructive pulmonary disease\n   3. Chronic heart disease\n\nExclusion Criteria:\n\n1. Age \\\u003C18 years and pregnant women\n2. Patients with a decision of not to resuscitate\n3. Poor echogenicity\n4. Severe mitral valve disease (leakage and\u002For stenosis, bioprosthesis)\n5. Patients with pacemaker\n6. Tracheostomy\n7. Chronic neuromuscular or neurodegenerative diseases","ALL","18 Years",{"count":89,"type":90},250,"ESTIMATED","INTERVENTIONAL",[93],"NA","The purpose of this study is to determine if the left and right ventricular systolic function is involved in the development of weaning failure related to weaning-induced pulmonary edema.",[96,97],"Mechanical Ventilation Complication","Pulmonary Edema","2026-05-21",{"date":100,"type":101},"2026-05-22","ACTUAL",{"date":103,"type":101},"2022-08-08",{"date":105,"type":90},"2026-09",{"name":5,"class":6},3]