[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641189":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":23,"responsibleParty":58,"collaborators":7,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":7,"eligibilityCriteria":65,"healthyVolunteers":62,"sex":66,"minAge":67,"maxAge":7,"enrollmentInfo":68,"targetDuration":71,"studyType":72,"phases":7,"briefSummary":73,"conditions":74,"keywords":7,"overallStatus":25,"whyStopped":7,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"University Hospital, Basel, Switzerland","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Cyrill Rentsch, Prof.","Universitätsspital Basel","PRINCIPAL_INVESTIGATOR",[14,19],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},"Heike Püschel","CONTACT","+41 61 55 65477","Heike.Pueschel@usb.ch",{"name":20,"role":16,"phone":21,"phoneExt":7,"email":22},"Niklas Simon","+41 61 55 65616","niklas.simon@usb.ch",[24,41],{"facility":11,"status":25,"city":26,"state":7,"zip":7,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"RECRUITING","Basel","Switzerland","CH",{"type":30,"coordinates":31},"Point",[32,33],7.57327,47.55839,{"lat":33,"lon":32},[36,37,39],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},{"name":20,"role":16,"phone":21,"phoneExt":7,"email":38},"Niklas.Simon@usb.ch",{"name":40,"role":12,"phone":7,"phoneExt":7,"email":7},"Cyrill Rentsch",{"facility":42,"status":25,"city":43,"state":7,"zip":7,"country":27,"countryCode":28,"cosmosGeoPoint":44,"geoPoint":48,"contacts":49},"Luzerner Kantonsspital","Lucerne",{"type":30,"coordinates":45},[46,47],8.30635,47.05048,{"lat":47,"lon":46},[50,53,56],{"name":51,"role":16,"phone":7,"phoneExt":7,"email":52},"Fabian Aschwanden","fabian.aschwanden@luks.ch",{"name":54,"role":16,"phone":7,"phoneExt":7,"email":55},"Tamara Lötscher","tamara.loetscher@luks.ch",{"name":57,"role":12,"phone":7,"phoneExt":7,"email":7},"Nico Grossmann",{"type":59,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100641189","t1g3r-1-trial-detectability-and-prognostic-value-of-ctdna-in-t1-g3-bladder-cancer-100641189",false,"NCT07581496","T1G3R-1 Trial: Detectability and Prognostic Value of ctDNA in T1 G3 Bladder Cancer","Inclusion Criteria:\n\n* patients \\> 18 years of age, able to give informed consent as documented by signature,\n* patients with a cystoscopically proven bladder cancer, suspicious for T1 stage, who will undergo TUR-B\n\nExclusion Criteria:\n\n* Patients with metastases or concomitant upper tract tumor at diagnosis will\n* Patients with non T1 G3 cancers\n* Patients with upstaging, either at re-TUR-B or after immediate radical cystectomy\n* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.\n* Vulnerable persons (e.g. \\\u003C 18y of age, unable to consent to the study)","ALL","18 Years",{"count":69,"type":70},35,"ESTIMATED","3 Years","OBSERVATIONAL","T1G3 bladder cancer is a heterogeneous disease with a high risk of disease persistence after the first TUR-B, understaging, disease progression, bladder removal, and mortality.\n\nCurrent risk stratification is insufficient and needs improvement. Ct-DNA could identify patients with disease persistence, progression and could monitor and tailor therapy. It might improve patient risk stratification, avoiding under- and overtreatment, reducing morbidity and mortality.\n\nPrimary objective is to investigate the detectability of ct-DNA in T1G3 urothelial bladder cancer patients and build a biobank through collection of different sample types (urine, plasma) in T1G3 bladder cancer patients which allows future retrospective testing.",[75],"Bladder Cancer","2026-05-14",{"date":78,"type":79},"2026-05-18","ACTUAL",{"date":81,"type":79},"2025-06-18",{"date":83,"type":70},"2030-06-01",{"name":5,"class":6},2]