[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100511955":3},{"organization":4,"armGroups":7,"interventions":35,"overallOfficials":48,"centralContacts":52,"locations":62,"responsibleParty":121,"collaborators":18,"id":123,"slug":124,"hasResults":125,"nctId":126,"briefTitle":127,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":125,"sex":130,"minAge":131,"maxAge":132,"enrollmentInfo":133,"targetDuration":18,"studyType":136,"phases":137,"briefSummary":139,"conditions":140,"keywords":142,"overallStatus":65,"whyStopped":18,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":155},{"fullName":5,"class":6},"National Heart Centre Singapore","OTHER",[8,14,19,24,27,32],{"label":9,"type":10,"description":11,"interventionNames":12},"Outpatient clinic\u002Fcommunity participants receiving exercise sessions and meals (A1)","EXPERIMENTAL","Outpatient clinic\u002Fcommunity participants receiving intervention Set A (exercise sessions and meals over approximately 12 weeks)",[13],"Other: Intervention Set A",{"label":15,"type":16,"description":17,"interventionNames":18},"Outpatient clinic\u002Fcommunity participants receiving control\u002Fusual care (A2)","NO_INTERVENTION","Outpatient clinic\u002Fcommunity participants receiving control\u002Fusual care",null,{"label":20,"type":10,"description":21,"interventionNames":22},"Step-down community hospital participants receiving exercise sessions and meals (B1)","Step-down community hospital participants receiving Intervention Set B (exercise sessions and meals over approximately 3 weeks)",[23],"Other: Intervention Set B",{"label":25,"type":16,"description":26,"interventionNames":18},"Step-down community hospital participants receiving control\u002Fusual care (B2)","Step-down community hospital participants receiving control\u002Fusual care",{"label":28,"type":10,"description":29,"interventionNames":30},"Acute hospital participants receiving meals (C1)","Acute hospital participants receiving Intervention Set C (meals over approximately 3 weeks)",[31],"Other: Intervention Set C",{"label":33,"type":16,"description":34,"interventionNames":18},"Acute hospital participants receiving control\u002Fusual care (C2)","Acute hospital participants receiving control\u002Fusual care",[36,40,44],{"type":6,"name":37,"description":38,"armGroupLabels":39,"otherNames":18},"Intervention Set A","exercise sessions and meals over approximately 12 weeks",[9],{"type":6,"name":41,"description":42,"armGroupLabels":43,"otherNames":18},"Intervention Set B","exercise sessions and meals over approximately 3 weeks",[20],{"type":6,"name":45,"description":46,"armGroupLabels":47,"otherNames":18},"Intervention Set C","meals over approximately 3 weeks",[28],[49],{"name":50,"affiliation":5,"role":51},"Angela Su-Mei Koh, MBBS, MPH","PRINCIPAL_INVESTIGATOR",[53,58],{"name":54,"role":55,"phone":56,"phoneExt":18,"email":57},"Angela Su-Mei Koh","CONTACT","+65 6704 8961","angela.koh.s.m@singhealth.com.sg",{"name":59,"role":55,"phone":60,"phoneExt":18,"email":61},"Gina Sihui Lee","+65 6704 2228","gina.lee.s.h@nhcs.com.sg",[63,78,86,95,104,113],{"facility":64,"status":65,"city":66,"state":18,"zip":67,"country":66,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":74,"contacts":75},"Alexandra Hospital","RECRUITING","Singapore","159964","SG",{"type":70,"coordinates":71},"Point",[72,73],103.85007,1.28967,{"lat":73,"lon":72},[76],{"name":77,"role":55,"phone":18,"phoneExt":18,"email":18},"Laureen Yi-Ting Wang",{"facility":5,"status":65,"city":66,"state":18,"zip":79,"country":66,"countryCode":68,"cosmosGeoPoint":80,"geoPoint":82,"contacts":83},"169609",{"type":70,"coordinates":81},[72,73],{"lat":73,"lon":72},[84,85],{"name":50,"role":55,"phone":56,"phoneExt":18,"email":57},{"name":59,"role":55,"phone":60,"phoneExt":18,"email":61},{"facility":87,"status":65,"city":66,"state":18,"zip":88,"country":66,"countryCode":68,"cosmosGeoPoint":89,"geoPoint":91,"contacts":92},"Changi General Hospital","529889",{"type":70,"coordinates":90},[72,73],{"lat":73,"lon":72},[93],{"name":94,"role":55,"phone":18,"phoneExt":18,"email":18},"Chun How Ooi",{"facility":96,"status":65,"city":66,"state":18,"zip":97,"country":66,"countryCode":68,"cosmosGeoPoint":98,"geoPoint":100,"contacts":101},"Sengkang General Hospital","544886",{"type":70,"coordinates":99},[72,73],{"lat":73,"lon":72},[102],{"name":103,"role":55,"phone":18,"phoneExt":18,"email":18},"Zijuan Huang",{"facility":105,"status":65,"city":66,"state":18,"zip":106,"country":66,"countryCode":68,"cosmosGeoPoint":107,"geoPoint":109,"contacts":110},"Jurong Community Hospital","609606",{"type":70,"coordinates":108},[72,73],{"lat":73,"lon":72},[111],{"name":112,"role":55,"phone":18,"phoneExt":18,"email":18},"Alvin Ong",{"facility":114,"status":65,"city":66,"state":18,"zip":18,"country":66,"countryCode":68,"cosmosGeoPoint":115,"geoPoint":117,"contacts":118},"NHG Polyclinics",{"type":70,"coordinates":116},[72,73],{"lat":73,"lon":72},[119],{"name":120,"role":55,"phone":18,"phoneExt":18,"email":18},"Shu Yun Tan",{"type":122,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100511955","tackling-disruptions-to-frailty-interventions-developing-personalized-interventions-targeted-for-older-persons-with-cardiac-frailty-100511955",false,"NCT05946174","Tackling Disruptions to Frailty Interventions: Developing Personalized Interventions Targeted for Older Persons With Cardiac Frailty","INDEPENDENCY","Inclusion Criteria:\n\n* Age ≥ 21 years old\n* Outdoor ambulant\n\nExclusion Criteria:\n\n1. Bed-bound\n2. Dementia (Stage 6 onwards)\n3. Residing in sheltered or nursing home\n4. Cancer (to avoid confounding with cardiac disease sequelae from cancer)\n5. Participation in ongoing clinical trials that involve interventional drugs or devices\n6. Uncontrolled hypertension (systolic blood pressure ≥160mmHg and\u002For diastolic blood pressure ≥90mmHg) despite being on treatment for hypertension\n7. Low blood pressure (systolic blood pressure \\\u003C90mmHg or diastolic blood pressure \\\u003C40mmHg)\n8. Uncontrolled atrial fibrillation (controlled atrial fibrillation is allowed)\n9. Ventricular arrhythmias (such as ventricular tachycardia)\n10. Renal failure on dialysis\n11. Chronic kidney disease Stage 4 and above\n12. Nephrotic syndrome\n13. Liver cirrhosis Child's B and above\n14. Inflammatory Bowel Disease\n15. Severe uncontrolled gout\n16. Poorly controlled Diabetes Hba1c ≥9%\n17. On warfarin\n18. Presence of food allergies (such as shell-fish, prawn)\n19. Patient's life expectancy is expected to be less than one year at the time of potential enrolment as assessed by the investigator\n20. Nasogastric or parenteral nutrition\n21. Hypertrophic cardiomyopathy\n22. Cardiac amyloidosis\n23. Cardiac sarcoidosis","ALL","21 Years","100 Years",{"count":134,"type":135},500,"ESTIMATED","INTERVENTIONAL",[138],"NA","Background: Muscle mass loss and metabolic dysfunction, exacerbated by inactivity and nutritional inadequacies, underpin both cardiovascular disease and frailty in ageing. The investigators' proposal seeks to develop interventions in exercise and diet that are targeted for older adults with cardiac frailty.\n\nMethods:\n\nThe investigators' proposal is a five-year study comprising of first phase (first 2-2.5 years) and second phase (next 2-2.5 years). In the first phase cardiac frail participants (up to N=500) from each healthcare transition (inpatient hospital, step-down community hospital, outpatient clinic\u002Fcommunity) will be randomized to receive Intervention Sets or usual care. The second phase will scale up these programs. Three Intervention Sets A, B, and C will be implemented in the outpatient, step-down community hospital, and acute hospital settings. Diet intervention comprises meal sets prepared with nutrients involved in energy metabolism. Exercise training is facilitated by hospital gyms and hospital physiotherapists. Diet and exercise behavior will be monitored using questionnaires, video conferencing and meal photos.\n\nSignificance: Clinical studies are urgently needed using consistent frailty tools to evaluate the efficacy and promise of frailty interventions, targeted to achieve reversal\u002Fretardation of frailty. When scaled up, these approaches will provide high-quality science needed to manage cardiac frailty towards healthier population ageing.",[141],"Cardiovascular Diseases",[143,144,145],"Frailty","Intervention","Cardiac Frailty Interventions","2025-06-03",{"date":148,"type":149},"2025-06-05","ACTUAL",{"date":151,"type":149},"2023-07-12",{"date":153,"type":135},"2028-06-21",{"name":5,"class":6},6]