[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637080":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":25,"locations":32,"responsibleParty":44,"collaborators":46,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":24,"enrollmentInfo":62,"targetDuration":24,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":83,"whyStopped":24,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Alexandra Hospital","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"Waitlist Control","Participants assigned to the waitlist control arm will receive usual care for the first 6 months of the study, consisting of standard educational materials on brain health. Following the 6-month assessment, waitlist control participants will receive full access to BLAZE for a further 6 months (months 6-12), identical to the intervention described in the immediate intervention arm.",[12],"Behavioral: BLAZE (Brain health Lifestyle Action with personaliZed Engagement)",{"label":14,"type":15,"description":16,"interventionNames":17},"BLAZE Intervention","ACTIVE_COMPARATOR","Participants assigned to the immediate intervention arm will receive access to BLAZE (Brain health Lifestyle Action with personaliZed Engagement) for 12 months.",[12],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","BLAZE (Brain health Lifestyle Action with personaliZed Engagement)","BLAZE is an AI-powered digital brain health coaching intervention delivered via a WhatsApp-based platform integrated with a large language model (LLM). Grounded in the COM-B behavioural framework, BLAZE operates through four integrated modules - Assessment, Education, Nudge, and Coaching - to deliver personalised recommendations, behavioural nudges, educational content, and goal-setting support. Personalisation is driven by each participant's Brain Care Score (BCS) profile, with intervention intensity stratified according to domain-specific scores. All content is informed by a curated knowledge base developed in collaboration with neurologists and geriatricians",[14,9],null,[26],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},"Dr Li Feng Tan","CONTACT","(65)85018320","+65","ah_brainhealth@nuhs.edu.sg",[33],{"facility":5,"status":24,"city":34,"state":34,"zip":24,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Singapore","SG",{"type":37,"coordinates":38},"Point",[39,40],103.85007,1.28967,{"lat":40,"lon":39},[43],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},{"type":45,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[47,49],{"name":48,"class":6},"National University Hospital, Singapore",{"name":50,"class":6},"National University Polyclinics, Singapore","100637080","tailored-brain-health-insights-through-nurturing-knowledge-based-change---stakeholder-driven-human-centered-ai-powered-refinement-for-prevention-100637080",false,"NCT07612800","Tailored Brain Health Insights Through Nurturing Knowledge-based Change - Stakeholder-driven, Human-centered, AI-powered Refinement for Prevention","Tailored Brain Health Insights Through Nurturing Knowledge-based Change - Stakeholder-driven, Human-centered, AI-powered Refinement for Prevention (THINK-SHARP)","THINK-SHARP","Inclusion Criteria:\n\n* Community-dwelling adults\n* Aged 40 years and above at time of recruitment\n* Able to use a smartphone and smartphone applications\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Been diagnosed wotj dementia, neurocognitive disorder or any major psychiatric illness\n* Have severe sensory or physical disability precluding usage of the application\n* Terminal illness or expected survival of less than 12 months at point of recruitment",true,"ALL","40 Years",{"count":63,"type":64},350,"ESTIMATED","INTERVENTIONAL",[67],"NA","The goal of this clinical trial is to evaluate whether an AI-powered digital brain health coaching intervention can improve modifiable brain health risk factors in community-dwelling adults aged 40 and above in Singapore.\n\nThe main question it aims to answer is: does the use of BLAZE, an AI-powered digital brain health coaching intervention, lead to a greater improvement in Brain Care Score (BCS) compared to usual care at 6 months?\n\nResearchers will compare participants receiving BLAZE to those receiving usual care (waitlist control) to see if BLAZE leads to greater improvements in brain health risk factors, behavioural outcomes, quality of life, and cost-effectiveness.\n\nParticipants will:\n\n* Be randomly assigned to either receive BLAZE immediately for 12 months or be placed on a waitlist receiving usual care for the first 6 months before receiving BLAZE for a further 6 months\n* Complete a series of assessments at baseline, 6 months, and 12 months including the Brain Care Score, physical function tests, cognitive assessments, quality of life measures, and lifestyle behaviour questionnaires\n* If assigned to the intervention group, interact with BLAZE via a WhatsApp-based platform that delivers personalised brain health recommendations, behavioural nudges, educational content, and goal-setting support based on their individual Brain Care Score profile",[70,71],"MCI","Dementia",[73,74,75,76,77,78,79,80,81,82],"COM-B","artificial intelligence","digital health intervention","mHealth","conversational agent","large language model","Whatsapp-based intervention","Just-in-time adaptive intervention (JITAI)","brain health coaching","behavioural nudging","NOT_YET_RECRUITING","2026-05-21",{"date":86,"type":87},"2026-05-29","ACTUAL",{"date":89,"type":64},"2026-09-01",{"date":91,"type":64},"2029-12-31",{"name":5,"class":6},1]