[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100334058":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":45,"responsibleParty":64,"collaborators":39,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":39,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":39,"enrollmentInfo":76,"targetDuration":39,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":89,"overallStatus":48,"whyStopped":39,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Peking University First Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Targeted blood-pressure management","EXPERIMENTAL","Prophylactic norepinephrine infusion is started at the beginning of anesthetic induction and maintained throughout surgery. The target is to maintain systolic blood pressure at 110 mmHg or higher during surgery.",[13],"Drug: Targeted blood-pressure management",{"label":15,"type":16,"description":17,"interventionNames":18},"Routine blood-pressure management","ACTIVE_COMPARATOR","Phenylephrine (25-50 ug) is injected or vasopressors is infused only when necessary. The target is to maintain systolic blood pressure at 90 mmHg or higher during surgery.",[19],"Drug: Routine blood-pressure management",[21,27],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Prophylactic norepinephrine infusion is started before anesthetic induction and maintained throughout surgery. The target is to maintain systolic blood pressure at 110 mmHg or higher.",[9],[26],"Norepinephrine",{"type":22,"name":15,"description":17,"armGroupLabels":28,"otherNames":29},[15],[30],"Phenylephrine and other vasopressors",[32],{"name":33,"affiliation":5,"role":34},"Dong-Xin Wang, MD, PhD","PRINCIPAL_INVESTIGATOR",[36,41],{"name":33,"role":37,"phone":38,"phoneExt":39,"email":40},"CONTACT","8610-83572784",null,"wangdongxin@hotmail.com",{"name":42,"role":37,"phone":43,"phoneExt":39,"email":44},"Li Huang, MD, PhD","8610-83572460","huanglibd@163.com",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Beijing University First Hospital","RECRUITING","Beijing","Beijing Municipality","100034","China","CN",{"type":55,"coordinates":56},"Point",[57,58],116.39723,39.9075,{"lat":58,"lon":57},[61,63],{"name":62,"role":37,"phone":38,"phoneExt":39,"email":40},"Dong-Xin Wang, MD, PHD",{"name":42,"role":37,"phone":43,"phoneExt":39,"email":44},{"type":34,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":39,"oldOrganization":39},"Dong-Xin Wang","Professor and Chairman, Department of Anaesthesiology and Critical Care Medicine","100334058","targeted-blood-pressure-management-and-acute-kidney-injury-after-coronary-artery-bypass-surgery-100334058",false,"NCT03629418","Targeted Blood-pressure Management and Acute Kidney Injury After Coronary Artery Bypass Surgery","Impact of Targeted Blood-pressure Management on Incidence of Acute Kidney Injury After Off-pump Coronary Artery Bypass Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 50 years;\n* Scheduled to undergo off-pump CABG surgery.\n\nExclusion Criteria:\n\n* Refuse to participate;\n* Untreated or uncontrolled severe hypertension (systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg);\n* Chronic kidney disease with a glomerular filtration rate \\\u003C 30 ml\u002Fmin\u002F1.73 m2 or end-stage renal disease requiring renal-replacement therapy;\n* Inability to communicate during the preoperative period because of coma, profound dementia, language barrier, or end-stage disease;\n* Requirement of vasopressors\u002Finotropics to maintain blood pressure before surgery;\n* Second or emergency surgery;\n* Expected survival of less than 24 hours.","ALL","50 Years",{"count":77,"type":78},612,"ESTIMATED","INTERVENTIONAL",[81],"NA","Acute renal injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. It is now realized that intraoperative hypotension is an important risk factor for the development of AKI. In a recent randomized controlled trial of patients undergoing major noncardiac surgery, intraoperative individualized blood-pressure management reduced the incidence of postoperative organ dysfunction. The investigators hypothesize that, for patients undergoing off-pump CABG, targeted blood-pressure management during surgery may also reduce the incidence of postoperative AKI.",[84,85,86,87,88],"Coronary Artery Bypass, Off-Pump","Intraoperative Hypotension","Acute Kidney Injury","Preventive Medicine","Intraoperative Care",[84,85,86,87,88],"2025-07-29",{"date":92,"type":93},"2025-07-30","ACTUAL",{"date":95,"type":93},"2018-08-14",{"date":97,"type":78},"2026-07",{"name":5,"class":6},1]