[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100569990":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":31,"responsibleParty":63,"collaborators":65,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":20,"eligibilityCriteria":74,"healthyVolunteers":71,"sex":75,"minAge":76,"maxAge":20,"enrollmentInfo":77,"targetDuration":20,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":34,"whyStopped":20,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Columbia University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1 - Intraoperative Participants","EXPERIMENTAL","Motor evoked responses responses (MEPs) to epidural electrical stimulation (EES) will be tested at cervical segments with and without myelopathy in participants with cervical myelopathy.",[13],"Procedure: Intraoperative stimulation of the cervical spinal cord",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Intraoperative stimulation of the cervical spinal cord","The surgeon will place spinal cord electrodes on the epidural surface, with stimulation sites identified using preoperative MRI. Recruitment curves will be generated by systematically increasing the stimulation intensity across various parameter combinations, including frequency, pulse count, pulse shape, and electrode-specific properties such as size, separation, and arrangement.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Jason B Carmel, M.D., Ph.D.","CONTACT","917-301-1882","jbc28@cumc.columbia.edu",{"name":28,"role":24,"phone":29,"phoneExt":20,"email":30},"James R McIntosh, Ph.D.","212-305-6616","jrm2263@cumc.columbia.edu",[32,49],{"facility":33,"status":34,"city":35,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Columbia University Irving Medical Center","RECRUITING","New York","10032","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-74.00597,40.71427,{"lat":43,"lon":42},[46,47],{"name":23,"role":24,"phone":29,"phoneExt":20,"email":26},{"name":28,"role":48,"phone":20,"phoneExt":20,"email":20},"SUB_INVESTIGATOR",{"facility":50,"status":34,"city":35,"state":35,"zip":51,"country":37,"countryCode":38,"cosmosGeoPoint":52,"geoPoint":54,"contacts":55},"The Daniel and Jane Och Spine Hospital at NewYork-Presbyterian\u002FAllen","10034",{"type":40,"coordinates":53},[42,43],{"lat":43,"lon":42},[56,60],{"name":57,"role":24,"phone":58,"phoneExt":20,"email":59},"Earl Thuet","212-932-4342","edt2116@cumc.columbia.edu",{"name":61,"role":62,"phone":20,"phoneExt":20,"email":20},"Jason Carmel","PRINCIPAL_INVESTIGATOR",{"type":62,"investigatorFullName":61,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Associate Professor",[66],{"name":67,"class":68},"Congressionally Directed Medical Research Programs","FED","100569990","targeting-cervical-epidural-spinal-cord-stimulation-for-functional-recovery-100569990",false,"NCT06701422","Targeting Cervical Epidural Spinal Cord Stimulation for Functional Recovery","Inclusion Criteria:\n\n•Clinical indication for cervical spine surgery.\n\nExclusion criteria:\n\n•Stimulation devices in the neck or chest (e.g., vagal nerve stimulation, cardiac patients with pacemakers)","ALL","18 Years",{"count":78,"type":79},36,"ESTIMATED","INTERVENTIONAL",[82],"NA","The proposed study seeks to understand how the cervical spinal cord should be stimulated after injury through short-term physiology experiments that will inform a preclinical efficacy trial. The purpose of this study is to determine which cervical levels epidural electrical stimulation (EES) should target to recruit arm and hand muscles effectively and selectively in spinal cord injury (SCI).",[85,86,87],"Cervical Spinal Cord Injury","Tetraplegia\u002FTetraparesis","Cervical Myelopathy",[89,90,91,92],"spinal cord injury","upper-limb muscle activation","cervical spinal cord","myelopathy","2025-11-20",{"date":95,"type":96},"2025-11-24","ACTUAL",{"date":98,"type":96},"2024-12-06",{"date":100,"type":79},"2026-06-30",{"name":5,"class":6},2]