[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100477562":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":31,"responsibleParty":50,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":54,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Chang Gung Memorial Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Post-acute systolic heart failure patients",null,"Patients who received at least one exercise training section within 3 months of acute heart failure discharge are placed in the CR group. Patients will receive a multi-disciplinary disease management program by a qualified HF nursing specialist. A board-certified physiatrist prescribes moderate continuous training according to a cardiopulmonary exercise test.",[13],"Behavioral: exercise based cardiac rehabilitation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"BEHAVIORAL","exercise based cardiac rehabilitation","The types of exercise are treadmill walking\u002Fwalking-jogging\u002Fjogging, ergometer cycling, stair climbing, or elliptical machine training. The training intensity is gradually increased fortnightly to reach the targeted Borg's rate of perceived exertion (RPE) of 12-14. The training duration is 40 minutes, which included 5-10 minutes of warm-up and cool-down exercises. The training frequency is three sessions per week, with 36 sessions concluding a complete course.",[9],[21],{"name":22,"affiliation":23,"role":24},"Shyh-Ming Che, MD","Chang Gung Medical Foundation","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":10,"email":30},"Hsin-Yen Tsai","CONTACT","+886929610850","milktea588@gmail.com",[32],{"facility":33,"status":34,"city":35,"state":10,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Chang Gung Memorial Hospital Heart Failure Center","RECRUITING","Kaohsiung City","83341","Taiwan","TW",{"type":40,"coordinates":41},"Point",[42,43],120.31333,22.61626,{"lat":43,"lon":42},[46,48],{"name":47,"role":28,"phone":29,"phoneExt":10,"email":30},"Hsin-yen Tsai",{"name":49,"role":24,"phone":10,"phoneExt":10,"email":10},"Shyh-Ming Chen, MD.",{"type":51,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100477562","targeting-loxl2-and-cardiac-fibrosis-for-post-acute-heart-failure-treatment--a-prospective-study-100477562",false,"NCT05498584","Targeting LOXL2 and Cardiac Fibrosis for Post-acute Heart Failure Treatment- A Prospective Study","Inclusion Criteria:\n\n1. Patients must give written informed consent before any assessment is performed.\n2. Inpatients \\>= 20 years of age, male or female.\n3. Patients with a diagnosis of heart failure New York Heart Association (NYHA) class II-IV with BNP \\>=100 pg\u002FmL or NT-porBNP \\>= 400 pg\u002FmL ( \\>= 900 pg\u002FmL if concomitant atrial fibrillation)\n4. Left ventricular ejection fraction \\\u003C= 40% by echocardiography or other methods\n\nExclusion Criteria:\n\n1. Estimated survival time \\\u003C 6 months\n2. Long-term bedridden for more than 3 months\n3. Cannot tolerate exercise test due to muscular skeletal disorder.\n4. Cannot cooperate all functional studies\n5. Ventilator dependent\n6. Terminal heart status\n7. Family rejects to participate in this project\n8. Primary severe valvular heart disease","ALL","20 Years","100 Years",{"count":62,"type":63},130,"ESTIMATED","OBSERVATIONAL","A previous study demonstrated that a multidisciplinary cardiac rehabilitation (CR) program was associated with reduced medium- to long-term all-cause mortality in a retrospective propensity score-matched study. The investigators will further investigate the predictors including LOXl2, cardiac MRI, and endothelial function that will benefit from a successful CR.",[67],"Heart Failure; With Decompensation",[69,70,71,72,73,74],"heart failure","cardiac fibrosis","cardiac rehabilitation","endothelial function","cardiopulmonary exercise test","cardiac MRI","2024-07-15",{"date":77,"type":78},"2024-07-16","ACTUAL",{"date":80,"type":78},"2022-08-25",{"date":82,"type":63},"2026-08-30",{"name":5,"class":6},1]