[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611931":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":55,"collaborators":11,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":11,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":11,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":11,"overallStatus":41,"whyStopped":11,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"University of Minnesota","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active tDCS + Cognitive Training","ACTIVE_COMPARATOR",null,[13],"Device: Active tDCS",{"label":15,"type":16,"description":11,"interventionNames":17},"Sham tDCS + Cognitive Training","PLACEBO_COMPARATOR",[18],"Device: Sham tDCS",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DEVICE","Active tDCS","All participants will receive 10 sessions of cognitive training focused on executive functions, delivered over approximately 3 weeks. Cognitive training will be completed on a lab provided computer using PositScience BrainHQ or TaskFlow software. Concurrently, during each training session, participants will receive either active or sham tDCS. Stimulation will be delivered via saline-soaked sponge electrodes using the Soterix 1x1 miniCT TES device. The anode (active electrode) will be placed over the L-DLPFC (approximated by EEG coordinate F3) and the cathode (reference electrode) over the contralateral supraorbital area (Fp2). The active tDCS group will receive 2mA constant current for 20 minutes.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Sham tDCS","All participants will receive 10 sessions of cognitive training focused on executive functions, delivered over approximately 3 weeks. Cognitive training will be completed on a lab provided computer using PositScience BrainHQ or TaskFlow software. Concurrently, during each training session, participants will receive either active or sham tDCS. Stimulation will be delivered via saline-soaked sponge electrodes using the Soterix 1x1 miniCT TES device. The anode (active electrode) will be placed over the L-DLPFC (approximated by EEG coordinate F3) and the cathode (reference electrode) over the contralateral supraorbital area (Fp2). The sham tDCS group will receive a brief ramp up and ramp down of current at the beginning and end of the 20 minutes to mimic the sensation of active stimulation.",[15],[30],{"name":31,"affiliation":5,"role":32},"Kelvin Lim, MD","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":11,"email":38},"Melanie Stimac","CONTACT","612-301-2549","stima011@umn.edu",[40],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Minneapolis","Minnesota","55455","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-93.26384,44.97997,{"lat":51,"lon":50},[54],{"name":35,"role":36,"phone":37,"phoneExt":11,"email":38},{"type":56,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100611931","targeting-neuroplasticity-for-persistent-post-concussive-cognitive-symptoms-100611931",false,"NCT07246993","Targeting Neuroplasticity for Persistent Post-Concussive Cognitive Symptoms","Targeting Neuroplasticity for Persistent Post-Concussive Cognitive Symptoms: A Trial of tDCS and Cognitive Training 3-12 Months Post-mTBI","Inclusion Criteria:\n\n* Age 18-65\n* Has sustained a single mTBI 3-12 months prior to enrollment\n* Meets criteria for PPCS (assessed using the CP Screen)\n* Has reliable access to a smartphone\n\nExclusion Criteria:\n\n* Inability to provide informed consent or complete study procedures\n* History of moderate\u002Fsevere TBI\n* Significant neurological or psychiatric disorders (other than PPCS-related symptoms like mild depression\u002Fanxiety)\n* Substance dependence within the last six months\n* Contraindications to tDCS (e.g., implanted metal, skin lesions on scalp)","ALL","18 Years","65 Years",{"count":68,"type":69},30,"ESTIMATED","INTERVENTIONAL",[72],"NA","This project investigates an innovative combination of non-invasive neuromodulation (transcranial direct current stimulation - tDCS) and cognitive training as a novel treatment approach aimed at improving function in individuals suffering from persistent post-concussive syndrome (PPCS) following mild traumatic brain injury (mTBI).",[75,76],"Persistent Post Concussion Syndrome","Mild Traumatic Brain Injury","2026-03-16",{"date":79,"type":80},"2026-03-17","ACTUAL",{"date":82,"type":80},"2026-03-05",{"date":84,"type":69},"2028-01-01",{"name":5,"class":6},1]