[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100449327":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":39,"responsibleParty":63,"collaborators":65,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":25,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Northwell Health","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Speeded Cognitive Training","EXPERIMENTAL","Participants in this condition will complete 40 hours of Cognitive Remediation with a mid-point assessment (20 hours\u002F5 weeks) to determine the impact of speeded cognitive training tasks on cognition and social function.",[13],"Behavioral: SCORES (Specific COgnitive Remediation with Support)",{"label":15,"type":16,"description":17,"interventionNames":18},"Non-Speeded Cognitive Training","ACTIVE_COMPARATOR","Participants in this condition will complete 40 hours of Cognitive Remediation with a mid-point assessment (20 hours\u002F5 weeks) to determine the impact of non-speeded cognitive training tasks on cognition and social function.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","SCORES (Specific COgnitive Remediation with Support)","This study evaluates the effectiveness of a 10-week cognitive remediation program plus group coaching and therapy to improve processing speed and, in turn, social functioning and attenuated positive symptoms in CHR subjects. The SCORES (Specific COgnitive Remediation with Support) intervention is a novel CR program combined with group coaching, performance-based rewards, game-like tasks, and therapy elements to increase engagement and retention.\n\nIn the 2 year, R61 phase, all participants will complete 40 hours of CR (4 hrs per week) with a mid-point assessment (20 hours of CR at 5 weeks) to determine the impact of CR on processing speed as measured by the MCCB.\n\nThe second phase of the study (R33) will compare the 40 hours of speeded brain training to 40 hours of non-speeded brain training. This three year study will allow for a replication and assessment of specificity of the targeted intervention.",[15,9],null,[27],{"name":28,"affiliation":5,"role":29},"Ricardo E Carrion, Ph.D.","PRINCIPAL_INVESTIGATOR",[31,35],{"name":28,"role":32,"phone":33,"phoneExt":25,"email":34},"CONTACT","718-470-8788","rcarrion@northwell.edu",{"name":36,"role":32,"phone":37,"phoneExt":25,"email":38},"Danielle McLaughlin, M.A.","718-470-8375","dmclaugh@northwell.edu",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Northwell Health- The Zucker Hillside Hospital","RECRUITING","Glen Oaks","New York","11042","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-73.71152,40.74705,{"lat":52,"lon":51},[55,59,60,62],{"name":56,"role":32,"phone":57,"phoneExt":25,"email":58},"Andrea M Auther, Ph.D.","718-470-8147","aauther@northwell.edu",{"name":36,"role":32,"phone":37,"phoneExt":25,"email":38},{"name":61,"role":29,"phone":25,"phoneExt":25,"email":25},"Barbara A Cornblatt, Ph.D.",{"name":28,"role":29,"phone":25,"phoneExt":25,"email":25},{"type":64,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[66],{"name":67,"class":68},"National Institute of Mental Health (NIMH)","NIH","100449327","targeting-processing-speed-deficits-to-improve-social-functioning-and-lower-psychosis-risk-100449327",false,"NCT05131035","Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk","Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk in Adolescents at Clinical High Risk for Psychosis","SCORES","Inclusion Criteria:\n\n* Meet Clinical High Risk (CHR) criteria on the Structured Interview for Psychosis Risk Syndromes, defined by the presence of at least one attenuated positive symptom at a moderate to severe level\n* A score representing 0.5 SD below the mean on Animal Naming, Trails A or BACS: Symbol Coding from the MATRICS Consensus Cognitive Battery (MCCB).\n\nExclusion Criteria:\n\n* Any DSM 5 Schizophrenia-Spectrum diagnosis\n* Non-English speaking\n* Past or current history of a clinically significant central nervous system disorder (e.g., seizure disorder)\n* Estimated IQ\\\u003C70\n* Significant head injury\n* Significant substance abuse\n* Significant visual or auditory impairment.","ALL","14 Years","20 Years",{"count":81,"type":82},54,"ESTIMATED","INTERVENTIONAL",[85],"NA","This 10 week intervention, Specific Cognitive Remediation with Surround (or SCORES), is designed to target processing speed, a cognitive domain related directly to social functioning, which in turn, represents a vulnerability factor for psychosis. This remotely-delivered intervention combining targeted cognitive training exercises and group support was developed to directly impact processing speed, and at the same time, boost motivation and engagement in adolescents at risk for schizophrenia and other psychotic disorders.",[88,89,90],"Psychosis","Prodromal Schizophrenia","Prodromal Symptoms",[92,93,94,95,96,97,98],"Clinical High Risk (CHR)","Processing Speed","Social Functioning","Social Impairment","Social Skills","Adolescents","Cognitive Remediation","2025-11-19",{"date":101,"type":102},"2025-11-24","ACTUAL",{"date":104,"type":102},"2021-10-28",{"date":106,"type":82},"2026-05-31",{"name":5,"class":6},1]